Literature DB >> 27314100

Mechanistic insights into the role of truncating PREX2 mutations in melanoma.

Yonathan Lissanu Deribe1.   

Abstract

PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to increased PI3K/AKT signaling and enhanced cell proliferation.

Entities:  

Keywords:  Epigenetics; Melanoma; Mouse models of cancer; PI3K; PREX2; RAC1

Year:  2016        PMID： 27314100      PMCID： PMC4909440          DOI： 10.1080/23723556.2016.1160174

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  P-Rex2, a new guanine-nucleotide exchange factor for Rac.

Authors:  Sarah Donald; Kirsti Hill; Charlotte Lecureuil; Romain Barnouin; Sonja Krugmann; W John Coadwell; Simon R Andrews; Simon A Walker; Phillip T Hawkins; Len R Stephens; Heidi C E Welch
Journal:  FEBS Lett       Date:  2004-08-13       Impact factor: 4.124

2.  PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.

Authors:  Sarah M Mense; Douglas Barrows; Cindy Hodakoski; Nicole Steinbach; David Schoenfeld; William Su; Benjamin D Hopkins; Tao Su; Barry Fine; Hanina Hibshoosh; Ramon Parsons
Journal:  Sci Signal       Date:  2015-03-31       Impact factor: 8.192

Review 3.  Lessons from the cancer genome.

Authors:  Levi A Garraway; Eric S Lander
Journal:  Cell       Date:  2013-03-28       Impact factor: 41.582

4.  The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Authors:  Christina M Lucato; Michelle L Halls; Lisa M Ooms; Heng-Jia Liu; Christina A Mitchell; James C Whisstock; Andrew M Ellisdon
Journal:  J Biol Chem       Date:  2015-06-24       Impact factor: 5.157

5.  Whole genomes redefine the mutational landscape of pancreatic cancer.

Authors:  Nicola Waddell; Marina Pajic; Ann-Marie Patch; David K Chang; Karin S Kassahn; Peter Bailey; Amber L Johns; David Miller; Katia Nones; Kelly Quek; Michael C J Quinn; Alan J Robertson; Muhammad Z H Fadlullah; Tim J C Bruxner; Angelika N Christ; Ivon Harliwong; Senel Idrisoglu; Suzanne Manning; Craig Nourse; Ehsan Nourbakhsh; Shivangi Wani; Peter J Wilson; Emma Markham; Nicole Cloonan; Matthew J Anderson; J Lynn Fink; Oliver Holmes; Stephen H Kazakoff; Conrad Leonard; Felicity Newell; Barsha Poudel; Sarah Song; Darrin Taylor; Nick Waddell; Scott Wood; Qinying Xu; Jianmin Wu; Mark Pinese; Mark J Cowley; Hong C Lee; Marc D Jones; Adnan M Nagrial; Jeremy Humphris; Lorraine A Chantrill; Venessa Chin; Angela M Steinmann; Amanda Mawson; Emily S Humphrey; Emily K Colvin; Angela Chou; Christopher J Scarlett; Andreia V Pinho; Marc Giry-Laterriere; Ilse Rooman; Jaswinder S Samra; James G Kench; Jessica A Pettitt; Neil D Merrett; Christopher Toon; Krishna Epari; Nam Q Nguyen; Andrew Barbour; Nikolajs Zeps; Nigel B Jamieson; Janet S Graham; Simone P Niclou; Rolf Bjerkvig; Robert Grützmann; Daniela Aust; Ralph H Hruban; Anirban Maitra; Christine A Iacobuzio-Donahue; Christopher L Wolfgang; Richard A Morgan; Rita T Lawlor; Vincenzo Corbo; Claudio Bassi; Massimo Falconi; Giuseppe Zamboni; Giampaolo Tortora; Margaret A Tempero; Anthony J Gill; James R Eshleman; Christian Pilarsky; Aldo Scarpa; Elizabeth A Musgrove; John V Pearson; Andrew V Biankin; Sean M Grimmond
Journal:  Nature       Date:  2015-02-26       Impact factor: 49.962

6.  Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA.

Authors:  Daisuke Urano; Asuka Nakata; Norikazu Mizuno; Kenji Tago; Hiroshi Itoh
Journal:  Cell Signal       Date:  2008-04-24       Impact factor: 4.315

7.  Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Authors:  Barry Fine; Cindy Hodakoski; Susan Koujak; Tao Su; Lao H Saal; Matthew Maurer; Benjamin Hopkins; Megan Keniry; Maria Luisa Sulis; Sarah Mense; Hanina Hibshoosh; Ramon Parsons
Journal:  Science       Date:  2009-09-04       Impact factor: 47.728

8.  Melanoma genome sequencing reveals frequent PREX2 mutations.

Authors:  Michael F Berger; Eran Hodis; Timothy P Heffernan; Yonathan Lissanu Deribe; Michael S Lawrence; Alexei Protopopov; Elena Ivanova; Ian R Watson; Elizabeth Nickerson; Papia Ghosh; Hailei Zhang; Rhamy Zeid; Xiaojia Ren; Kristian Cibulskis; Andrey Y Sivachenko; Nikhil Wagle; Antje Sucker; Carrie Sougnez; Robert Onofrio; Lauren Ambrogio; Daniel Auclair; Timothy Fennell; Scott L Carter; Yotam Drier; Petar Stojanov; Meredith A Singer; Douglas Voet; Rui Jing; Gordon Saksena; Jordi Barretina; Alex H Ramos; Trevor J Pugh; Nicolas Stransky; Melissa Parkin; Wendy Winckler; Scott Mahan; Kristin Ardlie; Jennifer Baldwin; Jennifer Wargo; Dirk Schadendorf; Matthew Meyerson; Stacey B Gabriel; Todd R Golub; Stephan N Wagner; Eric S Lander; Gad Getz; Lynda Chin; Levi A Garraway
Journal:  Nature       Date:  2012-05-09       Impact factor: 49.962

9.  Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.

Authors:  Yonathan Lissanu Deribe; Yanxia Shi; Kunal Rai; Luigi Nezi; Samir B Amin; Chia-Chin Wu; Kadir C Akdemir; Mozhdeh Mahdavi; Qian Peng; Qing Edward Chang; Kirsti Hornigold; Stefan T Arold; Heidi C E Welch; Levi A Garraway; Lynda Chin
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205

10.  Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.

Authors:  Cindy Hodakoski; Benjamin D Hopkins; Douglas Barrows; Sarah M Mense; Megan Keniry; Karen E Anderson; Philip A Kern; Phillip T Hawkins; Len R Stephens; Ramon Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-23       Impact factor: 11.205
  10 in total
  1 in total

Review 1.  Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches.

Authors:  Giuseppe Palmieri; Maria Colombino; Milena Casula; Antonella Manca; Mario Mandalà; Antonio Cossu
Journal:  Curr Oncol Rep       Date:  2018-09-14       Impact factor: 5.075
  1 in total

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