Literature DB >> 27314095

Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants.

Vijay K Ulaganathan1, Axel Ullrich1.   

Abstract

In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic) domains are pursued with great interest. However, in our recent publication we report that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the prognosis of heritable cancer.

Entities:  

Keywords:  Cancer-associated germline variant; FGFR4 Arg388 variant; Membrane-proximal STAT3 signaling; SNP rs351855; STAT3 signaling; Transmembrane variants; cancer prognosis; common germline variant; gain-of-function FGFR4 gene variant

Year:  2016        PMID： 27314095      PMCID： PMC4909399          DOI： 10.1080/23723556.2016.1145176

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation.

Authors:  D Chasman; R M Adams
Journal:  J Mol Biol       Date:  2001-03-23       Impact factor: 5.469

2.  Basic charge clusters and predictions of membrane protein topology.

Authors:  Davor Juretić; Larisa Zoranić; Damir Zucić
Journal:  J Chem Inf Comput Sci       Date:  2002 May-Jun

3.  Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes.

Authors:  Johan Nilsson; Bengt Persson; Gunnar von Heijne
Journal:  Proteins       Date:  2005-09-01

4.  Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.

Authors:  Johannes Bange; Dieter Prechtl; Yuri Cheburkin; Katja Specht; Nadia Harbeck; Manfred Schmitt; Tatjana Knyazeva; Susanne Müller; Silvia Gärtner; Irmi Sures; Hongyang Wang; Evgeny Imyanitov; Hans-Ulrich Häring; Pjotr Knayzev; Stefano Iacobelli; Heinz Höfler; Axel Ullrich
Journal:  Cancer Res       Date:  2002-02-01       Impact factor: 12.701

Review 5.  Human genetic variation and its contribution to complex traits.

Authors:  Kelly A Frazer; Sarah S Murray; Nicholas J Schork; Eric J Topol
Journal:  Nat Rev Genet       Date:  2009-04       Impact factor: 53.242

6.  Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif.

Authors:  Huang Shao; Xuejun Xu; Mary-Ann A Mastrangelo; Naijie Jing; Richard G Cook; Glen B Legge; David J Tweardy
Journal:  J Biol Chem       Date:  2004-02-13       Impact factor: 5.157

7.  Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.

Authors:  Vijay K Ulaganathan; Bianca Sperl; Ulf R Rapp; Axel Ullrich
Journal:  Nature       Date:  2015-12-16       Impact factor: 49.962
  7 in total
  3 in total

1.  STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion.

Authors:  Daniel Kogan; Alexander Grabner; Christopher Yanucil; Christian Faul; Vijay Kumar Ulaganathan
Journal:  J Clin Invest       Date:  2018-04-03       Impact factor: 14.808

2.  Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis.

Authors:  Si-Wei Xiong; Jianqun Ma; Fen Feng; Wen Fu; Shan-Rong Shu; Tianjiao Ma; Caixia Wu; Guo-Chang Liu; Jinhong Zhu
Journal:  Oncotarget       Date:  2017-04-11

3.  FGFR4 Gly388Arg Polymorphism Affects the Progression of Gastric Cancer by Activating STAT3 Pathway to Induce Epithelial to Mesenchymal Transition.

Authors:  Yanwei Ye; Jie Li; Dongbao Jiang; Jingjing Li; Chuangfeng Xiao; Yingze Li; Chao Han; Chunlin Zhao
Journal:  Cancer Res Treat       Date:  2020-05-25       Impact factor: 4.679
  3 in total

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