Literature DB >> 27314091

Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.

Mohammad Asim1, Charlie E Massie1, David E Neal1.   

Abstract

To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.

Entities:  

Keywords:  Androgen Receptor; chaperones; prostate cancer; therapeutic target

Year:  2016        PMID： 27314091      PMCID： PMC4909410          DOI： 10.1080/23723556.2016.1140262

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer.

Authors:  Kai-Hsiung Chang; Rui Li; Barbara Kuri; Yair Lotan; Claus G Roehrborn; Jiayan Liu; Robert Vessella; Peter S Nelson; Payal Kapur; Xiaofeng Guo; Hamid Mirzaei; Richard J Auchus; Nima Sharifi
Journal:  Cell       Date:  2013-08-29       Impact factor: 41.582

2.  Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.

Authors:  Mohammad Asim; Bilal Bin Hafeez; Imtiaz Ahmad Siddiqui; Claudia Gerlach; Michaela Patz; Hasan Mukhtar; Aria Baniahmad
Journal:  J Biol Chem       Date:  2011-08-19       Impact factor: 5.157

3.  Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway.

Authors:  Ying Yu; Avula Sreenivas; Darin B Ostrander; George M Carman
Journal:  J Biol Chem       Date:  2002-07-08       Impact factor: 5.157

4.  Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity.

Authors:  Amina Zoubeidi; Anousheh Zardan; Eliana Beraldi; Ladan Fazli; Richard Sowery; Paul Rennie; Colleen Nelson; Martin Gleave
Journal:  Cancer Res       Date:  2007-11-01       Impact factor: 12.701

Review 5.  Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer.

Authors:  Howard I Scher; Grant Buchanan; William Gerald; Lisa M Butler; Wayne D Tilley
Journal:  Endocr Relat Cancer       Date:  2004-09       Impact factor: 5.678

6.  Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.

Authors:  M Asim; I A Siddiqui; B B Hafeez; A Baniahmad; H Mukhtar
Journal:  Oncogene       Date:  2008-01-28       Impact factor: 9.867

7.  Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

Authors:  Mohammad Asim; Charles E Massie; Folake Orafidiya; Nelma Pértega-Gomes; Anne Y Warren; Mohsen Esmaeili; Luke A Selth; Heather I Zecchini; Katarina Luko; Arham Qureshi; Ajoeb Baridi; Suraj Menon; Basetti Madhu; Carlos Escriu; Scott Lyons; Sarah L Vowler; Vincent R Zecchini; Greg Shaw; Wiebke Hessenkemper; Roslin Russell; Hisham Mohammed; Niki Stefanos; Andy G Lynch; Elena Grigorenko; Clive D'Santos; Chris Taylor; Alastair Lamb; Rouchelle Sriranjan; Jiali Yang; Rory Stark; Scott M Dehm; Paul S Rennie; Jason S Carroll; John R Griffiths; Simon Tavaré; Ian G Mills; Iain J McEwan; Aria Baniahmad; Wayne D Tilley; David E Neal
Journal:  J Natl Cancer Inst       Date:  2015-12-11       Impact factor: 13.506
  7 in total
  2 in total

1.  MALAT1 as a Regulator of the Androgen-Dependent Choline Kinase A Gene in the Metabolic Rewiring of Prostate Cancer.

Authors:  Sara De Martino; Egidio Iorio; Chiara Cencioni; Aurora Aiello; Francesco Spallotta; Mattea Chirico; Maria Elena Pisanu; Claudio Grassi; Alfredo Pontecorvi; Carlo Gaetano; Simona Nanni; Antonella Farsetti
Journal:  Cancers (Basel)       Date:  2022-06-12       Impact factor: 6.575

Review 2.  Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases.

Authors:  Juan Carlos Lacal; Tahl Zimmerman; Joaquín M Campos
Journal:  Pharmaceutics       Date:  2021-05-25       Impact factor: 6.321
  2 in total

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