Literature DB >> 27314088

FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer.

Bingchen Han1, Ying Qu1, Yi Yu-Rice1, Jeffrey Johnson1, Xiaojiang Cui1.   

Abstract

The Forkhead box C1 (FOXC1) transcriptional factor is a critical biomarker for basal-like breast cancer (BLBC). We recently reported that FOXC1 promotes cancer stem cell properties in BLBC by activating Smoothened (SMO)-independent Hedgehog (Hh) signaling, suggesting a FOXC1-mediated mechanism for BLBC cell function and anti-Hh therapy resistance.

Entities:  

Keywords:  Basal-like breast cancer; FOXC1; GLI2; Hedgehog; Smoothened; cancer stem cells

Year:  2016        PMID： 27314088      PMCID： PMC4909418          DOI： 10.1080/23723556.2015.1131668

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer.

Authors:  Partha S Ray; Jinhua Wang; Ying Qu; Myung-Shin Sim; Jaime Shamonki; Sanjay P Bagaria; Xing Ye; Bingya Liu; David Elashoff; Dave S Hoon; Michael A Walter; John W Martens; Andrea L Richardson; Armando E Giuliano; Xiaojiang Cui
Journal:  Cancer Res       Date:  2010-04-20       Impact factor: 12.701

2.  Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.

Authors:  Suling Liu; Gabriela Dontu; Ilia D Mantle; Shivani Patel; Nam-shik Ahn; Kyle W Jackson; Prerna Suri; Max S Wicha
Journal:  Cancer Res       Date:  2006-06-15       Impact factor: 12.701

3.  Cell type-specific DNA methylation patterns in the human breast.

Authors:  Noga Bloushtain-Qimron; Jun Yao; Eric L Snyder; Michail Shipitsin; Lauren L Campbell; Sendurai A Mani; Min Hu; Haiyan Chen; Vadim Ustyansky; Jessica E Antosiewicz; Pedram Argani; Marc K Halushka; James A Thomson; Paul Pharoah; Angel Porgador; Saraswati Sukumar; Ramon Parsons; Andrea L Richardson; Martha R Stampfer; Rebecca S Gelman; Tatiana Nikolskaya; Yuri Nikolsky; Kornelia Polyak
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-09       Impact factor: 11.205

4.  Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay.

Authors:  Tor W Jensen; Tania Ray; Jinhua Wang; Xiaodong Li; Wesley Y Naritoku; Bingchen Han; Frank Bellafiore; Sanjay P Bagaria; Annie Qu; Xiaojiang Cui; Clive R Taylor; Partha S Ray
Journal:  J Natl Cancer Inst       Date:  2015-06-03       Impact factor: 13.506

5.  Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.

Authors:  Yoshiki Omatsu; Masanari Seike; Tatsuki Sugiyama; Tsutomu Kume; Takashi Nagasawa
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962

6.  Molecular portraits of human breast tumours.

Authors:  C M Perou; T Sørlie; M B Eisen; M van de Rijn; S S Jeffrey; C A Rees; J R Pollack; D T Ross; H Johnsen; L A Akslen; O Fluge; A Pergamenschikov; C Williams; S X Zhu; P E Lønning; A L Børresen-Dale; P O Brown; D Botstein
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

7.  An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors.

Authors:  Ittai Ben-Porath; Matthew W Thomson; Vincent J Carey; Ruping Ge; George W Bell; Aviv Regev; Robert A Weinberg
Journal:  Nat Genet       Date:  2008-05       Impact factor: 38.330

8.  FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.

Authors:  Bingchen Han; Ying Qu; Yanli Jin; Yi Yu; Nan Deng; Kolja Wawrowsky; Xiao Zhang; Na Li; Shikha Bose; Qiang Wang; Sugunadevi Sakkiah; Ravinder Abrol; Tor W Jensen; Benjamin P Berman; Hisashi Tanaka; Jeffrey Johnson; Bowen Gao; Jijun Hao; Zhenqiu Liu; Ralph Buttyan; Partha S Ray; Mien-Chie Hung; Armando E Giuliano; Xiaojiang Cui
Journal:  Cell Rep       Date:  2015-11-03       Impact factor: 9.423

9.  Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.

Authors:  Sylviane Dennler; Jocelyne André; Ismini Alexaki; Allen Li; Thierry Magnaldo; Peter ten Dijke; Xiao-Jing Wang; Franck Verrecchia; Alain Mauviel
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701
  9 in total
  5 in total

1.  ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.

Authors:  Khoa Nguyen; Yuanqing Yan; Bin Yuan; Abhishek Dasgupta; Jeffrey Sun; Hong Mu; Kim-Anh Do; Naoto T Ueno; Michael Andreeff; V Lokesh Battula
Journal:  Mol Cancer Ther       Date:  2018-09-20       Impact factor: 6.261

2.  Retracted Article: FOXC1 silencing promotes A549 cell apoptosis through inhibiting the PI3K/AKT/hedgehog/Gli2 signaling pathway.

Authors:  Pei Wang; Hongbing Ma; Yong Li; Dong Chen; Xiaohui Li; Xiang Gao
Journal:  RSC Adv       Date:  2018-10-02       Impact factor: 4.036

Review 3.  HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.

Authors:  Babak Nami; Zhixiang Wang
Journal:  Cancers (Basel)       Date:  2017-04-26       Impact factor: 6.639

Review 4.  FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles.

Authors:  Zhi Yang; Shuai Jiang; Yicheng Cheng; Tian Li; Wei Hu; Zhiqiang Ma; Fulin Chen; Yang Yang
Journal:  Ther Adv Med Oncol       Date:  2017-11-23       Impact factor: 8.168

Review 5.  Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.

Authors:  Zhihong Yao; Lei Han; Yongbin Chen; Fei He; Bin Sun; Santosh Kamar; Ya Zhang; Yihao Yang; Cao Wang; Zuozhang Yang
Journal:  Cell Death Dis       Date:  2018-06-13       Impact factor: 8.469
  5 in total

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