Literature DB >> 27314076

A mitosis-sensing caspase activation platform? New insights into the PIDDosome.

Richa B Shah1, Ruth Thompson1, Samuel Sidi1.   

Abstract

In contrast to the apoptosome and death-inducing signaling complex, the PIDDosome remains an orphan caspase activation platform unassigned to a specific apoptotic pathway. We found that DNA damage-induced PIDDosome formation is blocked by the mitotic checkpoint factor BUBR1 (budding uninhibited by benzimidazole-related 1), via a direct interaction that disrupts the PIDDosome core scaffold. This inhibition occurs at the kinetochore, thus physically connecting the mitotic and apoptotic machineries.

Entities:  

Keywords:  Apoptosis; BubR1; DNA damage; PIDD; PIDDosome; RAIDD; caspase-2; kinetochore; mitotic checkpoint

Year:  2015        PMID： 27314076      PMCID： PMC4909455          DOI： 10.1080/23723556.2015.1059921

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

Authors:  Antoine Tinel; Jürg Tschopp
Journal:  Science       Date:  2004-04-08       Impact factor: 47.728

Review 2.  New insights into the role of BubR1 in mitosis and beyond.

Authors:  Roger E Karess; Katja Wassmann; Zohra Rahmani
Journal:  Int Rev Cell Mol Biol       Date:  2013       Impact factor: 6.813

3.  An Inhibitor of PIDDosome Formation.

Authors:  Ruth Thompson; Richa B Shah; Peter H Liu; Yogesh K Gupta; Kiyohiro Ando; Aneel K Aggarwal; Samuel Sidi
Journal:  Mol Cell       Date:  2015-04-30       Impact factor: 17.970

4.  Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.

Authors:  Joshua L Andersen; Carrie E Johnson; Christopher D Freel; Amanda B Parrish; Jennifer L Day; Marisa R Buchakjian; Leta K Nutt; J Will Thompson; M Arthur Moseley; Sally Kornbluth
Journal:  EMBO J       Date:  2009-09-03       Impact factor: 11.598

5.  Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

Authors:  Margaret E Harley; Lindsey A Allan; Helen S Sanderson; Paul R Clarke
Journal:  EMBO J       Date:  2010-06-04       Impact factor: 11.598

6.  APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

Authors:  Lixin Wan; Mingjia Tan; Jie Yang; Hiroyuki Inuzuka; Xiangpeng Dai; Tao Wu; Jia Liu; Shavali Shaik; Guoan Chen; Jing Deng; Marcos Malumbres; Anthony Letai; Marc W Kirschner; Yi Sun; Wenyi Wei
Journal:  Dev Cell       Date:  2014-05-27       Impact factor: 12.270

7.  Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

Authors:  Maria Castedo; Jean-Luc Perfettini; Thomas Roumier; Alexander Valent; Hana Raslova; Kenichi Yakushijin; David Horne; Jean Feunteun; Gilbert Lenoir; René Medema; William Vainchenker; Guido Kroemer
Journal:  Oncogene       Date:  2004-05-27       Impact factor: 9.867

8.  PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.

Authors:  Kiyohiro Ando; Jennifer L Kernan; Peter H Liu; Takaomi Sanda; Emmanuelle Logette; Jurg Tschopp; A Thomas Look; Jianlong Wang; Lisa Bouchier-Hayes; Samuel Sidi
Journal:  Mol Cell       Date:  2012-07-30       Impact factor: 17.970

Review 9.  The spindle-assembly checkpoint in space and time.

Authors:  Andrea Musacchio; Edward D Salmon
Journal:  Nat Rev Mol Cell Biol       Date:  2007-04-11       Impact factor: 94.444

10.  DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.

Authors:  Eun Mi Kim; Daniel J Burke
Journal:  PLoS Genet       Date:  2008-02-29       Impact factor: 5.917
  10 in total
  1 in total

Review 1.  How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice.

Authors:  Ruth Thompson; Rachel Gatenby; Samuel Sidi
Journal:  Cells       Date:  2019-09-07       Impact factor: 6.600
  1 in total

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