Literature DB >> 27314075

Nore1a drives Ras to flick the P53 senescence switch.

Howard Donninger1, Geoffrey J Clark2.   

Abstract

RAS-induced senescence is a protective mechanism to avoid unrestricted cell growth due to aberrant mitogenic signals; however, the exact mechanism by which RAS induces senescence is not known. We recently identified a novel pathway linking RAS to p53 via NORE1A and HIPK2 that mechanistically explains how Ras induces senescence.

Entities:  

Keywords:  HIPK2; NORE1A; Ras; p53; senescence

Year:  2015        PMID： 27314075      PMCID： PMC4909421          DOI： 10.1080/23723556.2015.1055050

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The dark side of Ras: regulation of apoptosis.

Authors:  Adrienne D Cox; Channing J Der
Journal:  Oncogene       Date:  2003-12-08       Impact factor: 9.867

2.  Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.

Authors:  Jikyoung Park; Soo Im Kang; Sun-Young Lee; Xian F Zhang; Myoung Shin Kim; Lisa F Beers; Dae-Sik Lim; Joseph Avruch; Ho-Shik Kim; Sean Bong Lee
Journal:  J Biol Chem       Date:  2010-09-01       Impact factor: 5.157

3.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors:  M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal:  Cell       Date:  1997-03-07       Impact factor: 41.582

Review 4.  Senescence in tumours: evidence from mice and humans.

Authors:  Manuel Collado; Manuel Serrano
Journal:  Nat Rev Cancer       Date:  2010-01       Impact factor: 60.716

5.  Identification of a novel Ras-regulated proapoptotic pathway.

Authors:  Andrei Khokhlatchev; Shahrooz Rabizadeh; Ramnik Xavier; Maria Nedwidek; Tao Chen; Xian-feng Zhang; Brian Seed; Joseph Avruch
Journal:  Curr Biol       Date:  2002-02-19       Impact factor: 10.834

6.  Oncogenic ras and p53 cooperate to induce cellular senescence.

Authors:  Gerardo Ferbeyre; Elisa de Stanchina; Athena W Lin; Emmanuelle Querido; Mila E McCurrach; Gregory J Hannon; Scott W Lowe
Journal:  Mol Cell Biol       Date:  2002-05       Impact factor: 4.272

Review 7.  The RASSF1A tumor suppressor.

Authors:  Howard Donninger; Michele D Vos; Geoffrey J Clark
Journal:  J Cell Sci       Date:  2007-09-15       Impact factor: 5.285

8.  NORE1A tumor suppressor candidate modulates p21CIP1 via p53.

Authors:  Diego F Calvisi; Howard Donninger; Michele D Vos; Michael J Birrer; Laura Gordon; Virna Leaner; Geoffrey J Clark
Journal:  Cancer Res       Date:  2009-05-12       Impact factor: 12.701

9.  NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.

Authors:  Howard Donninger; Diego F Calvisi; Thibaut Barnoud; Jennifer Clark; M Lee Schmidt; Michele D Vos; Geoffrey J Clark
Journal:  J Cell Biol       Date:  2015-03-16       Impact factor: 10.539

Review 10.  The Ras-association domain family (RASSF) members and their role in human tumourigenesis.

Authors:  Louise van der Weyden; David J Adams
Journal:  Biochim Biophys Acta       Date:  2007-07-04
  10 in total
  1 in total

Review 1.  The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.

Authors:  Thibaut Barnoud; M Lee Schmidt; Howard Donninger; Geoffrey J Clark
Journal:  Cancer Lett       Date:  2017-04-26       Impact factor: 8.679
  1 in total

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