Literature DB >> 27314071

Ferroptosis: A missing puzzle piece in the p53 blueprint?

Shang-Jui Wang1, Yang Ou1, Le Jiang1, Wei Gu1.   

Abstract

Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.

Entities:  

Keywords:  Ferroptosis; metabolism; non-apoptotic cell death; p53; tumor suppression

Year:  2015        PMID： 27314071      PMCID： PMC4909446          DOI： 10.1080/23723556.2015.1046581

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.

Authors:  Sawako Suzuki; Tomoaki Tanaka; Masha V Poyurovsky; Hidekazu Nagano; Takafumi Mayama; Shuichi Ohkubo; Maria Lokshin; Hiroyuki Hosokawa; Toshinori Nakayama; Yutaka Suzuki; Sumio Sugano; Eiichi Sato; Toshitaka Nagao; Koutaro Yokote; Ichiro Tatsuno; Carol Prives
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

2.  Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.

Authors:  Colleen A Brady; Dadi Jiang; Stephano S Mello; Thomas M Johnson; Lesley A Jarvis; Margaret M Kozak; Daniela Kenzelmann Broz; Shashwati Basak; Eunice J Park; Margaret E McLaughlin; Anthony N Karnezis; Laura D Attardi
Journal:  Cell       Date:  2011-05-13       Impact factor: 41.582

3.  TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

Authors:  Karim Bensaad; Atsushi Tsuruta; Mary A Selak; M Nieves Calvo Vidal; Katsunori Nakano; Ramon Bartrons; Eyal Gottlieb; Karen H Vousden
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

4.  Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.

Authors:  Wenwei Hu; Cen Zhang; Rui Wu; Yvonne Sun; Arnold Levine; Zhaohui Feng
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-08       Impact factor: 11.205

5.  Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

Authors:  Tongyuan Li; Ning Kon; Le Jiang; Minjia Tan; Thomas Ludwig; Yingming Zhao; Richard Baer; Wei Gu
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

6.  Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Authors:  Scott J Dixon; Kathryn M Lemberg; Michael R Lamprecht; Rachid Skouta; Eleina M Zaitsev; Caroline E Gleason; Darpan N Patel; Andras J Bauer; Alexandra M Cantley; Wan Seok Yang; Barclay Morrison; Brent R Stockwell
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

7.  Ferroptosis as a p53-mediated activity during tumour suppression.

Authors:  Le Jiang; Ning Kon; Tongyuan Li; Shang-Jui Wang; Tao Su; Hanina Hibshoosh; Richard Baer; Wei Gu
Journal:  Nature       Date:  2015-03-18       Impact factor: 49.962

8.  Regulation of ferroptotic cancer cell death by GPX4.

Authors:  Wan Seok Yang; Rohitha SriRamaratnam; Matthew E Welsch; Kenichi Shimada; Rachid Skouta; Vasanthi S Viswanathan; Jaime H Cheah; Paul A Clemons; Alykhan F Shamji; Clary B Clish; Lewis M Brown; Albert W Girotti; Virginia W Cornish; Stuart L Schreiber; Brent R Stockwell
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

Review 9.  p53--a Jack of all trades but master of none.

Authors:  Melissa R Junttila; Gerard I Evan
Journal:  Nat Rev Cancer       Date:  2009-09-24       Impact factor: 60.716

Review 10.  Metabolic regulation by p53 family members.

Authors:  Celia R Berkers; Oliver D K Maddocks; Eric C Cheung; Inbal Mor; Karen H Vousden
Journal:  Cell Metab       Date:  2013-08-15       Impact factor: 27.287
  10 in total
  10 in total

Review 1.  Tumor suppressor p53 and metabolism.

Authors:  Juan Liu; Cen Zhang; Wenwei Hu; Zhaohui Feng
Journal:  J Mol Cell Biol       Date:  2019-04-01       Impact factor: 6.216

Review 2.  Non-Apoptotic Cell Death Signaling Pathways in Melanoma.

Authors:  Mariusz L Hartman
Journal:  Int J Mol Sci       Date:  2020-04-23       Impact factor: 5.923

Review 3.  The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway.

Authors:  Juan Liu; Cen Zhang; Jianming Wang; Wenwei Hu; Zhaohui Feng
Journal:  Int J Mol Sci       Date:  2020-11-09       Impact factor: 5.923

Review 4.  TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers.

Authors:  Hanyang Li; He Fang; Li Chang; Shuang Qiu; Xiaojun Ren; Lidong Cao; Jinda Bian; Zhenxiao Wang; Yi Guo; Jiayin Lv; Zhihui Sun; Tiejun Wang; Bingjin Li
Journal:  Front Immunol       Date:  2021-12-02       Impact factor: 7.561

5.  Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells.

Authors:  Shahnaz Babaei-Abraki; Fereshteh Karamali; Mohammad Hossein Nasr-Esfahani
Journal:  J Biol Chem       Date:  2022-03-23       Impact factor: 5.486

Review 6.  Non-Canonical Cell Death Induced by p53.

Authors:  Atul Ranjan; Tomoo Iwakuma
Journal:  Int J Mol Sci       Date:  2016-12-09       Impact factor: 5.923

7.  BAP1 links metabolic regulation of ferroptosis to tumour suppression.

Authors:  Yilei Zhang; Jiejun Shi; Xiaoguang Liu; Li Feng; Zihua Gong; Pranavi Koppula; Kapil Sirohi; Xu Li; Yongkun Wei; Hyemin Lee; Li Zhuang; Gang Chen; Zhen-Dong Xiao; Mien-Chie Hung; Junjie Chen; Peng Huang; Wei Li; Boyi Gan
Journal:  Nat Cell Biol       Date:  2018-09-10       Impact factor: 28.824

Review 8.  Small molecule activators of the p53 response.

Authors:  Marcus J G W Ladds; Sonia Laín
Journal:  J Mol Cell Biol       Date:  2019-03-01       Impact factor: 6.216

9.  Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice.

Authors:  Sathish Sivaprakasam; Bojana Ristic; Nithya Mudaliar; Abdul N Hamood; Jane Colmer-Hamood; Mitchell S Wachtel; Anna G Nevels; Kameswara R Kottapalli; Vadivel Ganapathy
Journal:  Biochem J       Date:  2020-10-16       Impact factor: 3.857

Review 10.  The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics.

Authors:  Chenise O'Garro; Loveth Igbineweka; Zonaira Ali; Mihaly Mezei; Shiraz Mujtaba
Journal:  Biomolecules       Date:  2021-03-18
  10 in total

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