Robert J Adams1, Sarah L Appleton2,3, Andrew Vakulin4,5, Carol Lang1, Sean A Martin6, Anne W Taylor7, R Doug McEvoy4,8, Nick A Antic4,8, Peter G Catcheside4,8, Gary A Wittert1,6. 1. The Health Observatory, Discipline of Medicine, University of Adelaide, Woodville, South Australia, Australia. 2. The Health Observatory, Discipline of Medicine, University of Adelaide, Woodville, South Australia, Australia. sarah.appleton@adelaide.edu.au. 3. Freemasons Centre for Men's Health, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. sarah.appleton@adelaide.edu.au. 4. Adelaide Institute for Sleep Health, a Flinders Centre of Research Excellence, School of Medicine, Faculty of Medicine, Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia. 5. NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia. 6. Freemasons Centre for Men's Health, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. 7. Population Research & Outcomes Studies, Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. 8. Department of Medicine, Flinders University, Bedford Park, Adelaide, South Australia, Australia.
Abstract
BACKGROUND AND OBJECTIVE: To determine correlates of excessive daytime sleepiness (EDS) identified with the Epworth Sleepiness Scale (ESS) and a more broad definition, while accounting for obstructive sleep apnoea (OSA) in community dwelling men. METHODS: Participants of the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (n = 837, ≥ 40 years) without a prior OSA diagnosis, underwent in-home full unattended polysomnography (PSG, Embletta X100), completed the ESS, STOP questionnaire and Pittsburgh Sleep Quality Index in 2010-2011. In 2007-2010, questionnaires and biomedical assessment (in South Australian public hospital-based clinics) identified medical conditions. An alternate EDS definition (EDSAlt ) consisted of ≥ 2 of 3 problems (feeling sleepy sitting quietly; feeling tired/fatigued/sleepy; trouble staying awake). RESULTS: EDSAlt (30.4%, n = 253), but not ESS ≥ 11 (EDSESS , 12.6%, n = 104), increased significantly across OSA severity and body mass index categories. In adjusted analyses, EDSESS was significantly associated with depression: odds ratio (OR), 95%CI: 2.2 (1.3-3.8) and nocturia: 2.0 (1.3-3.2). EDSAlt was associated with depression, financial stress, relationship, work-life balance problems and associations with nocturia and diabetes were borderline. After excluding men with EDSESS , EDSAlt was associated with oxygen desaturation index (3%) ≥ 16 and the highest arousal index quartile but not with comorbidities. CONCLUSION: Sleepiness not necessarily leading to dozing, but not ESS ≥ 11, was related to sleep disordered breathing. Clinicians should be alert to (1) differing perspectives of sleepiness for investigation and treatment of OSA, and (2) the presence of depression and nocturia in men presenting with significant Epworth sleepiness regardless of the presence of OSA.
BACKGROUND AND OBJECTIVE: To determine correlates of excessive daytime sleepiness (EDS) identified with the Epworth Sleepiness Scale (ESS) and a more broad definition, while accounting for obstructive sleep apnoea (OSA) in community dwelling men. METHODS:Participants of the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) Study (n = 837, ≥ 40 years) without a prior OSA diagnosis, underwent in-home full unattended polysomnography (PSG, Embletta X100), completed the ESS, STOP questionnaire and Pittsburgh Sleep Quality Index in 2010-2011. In 2007-2010, questionnaires and biomedical assessment (in South Australian public hospital-based clinics) identified medical conditions. An alternate EDS definition (EDSAlt ) consisted of ≥ 2 of 3 problems (feeling sleepy sitting quietly; feeling tired/fatigued/sleepy; trouble staying awake). RESULTS: EDSAlt (30.4%, n = 253), but not ESS ≥ 11 (EDSESS , 12.6%, n = 104), increased significantly across OSA severity and body mass index categories. In adjusted analyses, EDSESS was significantly associated with depression: odds ratio (OR), 95%CI: 2.2 (1.3-3.8) and nocturia: 2.0 (1.3-3.2). EDSAlt was associated with depression, financial stress, relationship, work-life balance problems and associations with nocturia and diabetes were borderline. After excluding men with EDSESS , EDSAlt was associated with oxygen desaturation index (3%) ≥ 16 and the highest arousal index quartile but not with comorbidities. CONCLUSION:Sleepiness not necessarily leading to dozing, but not ESS ≥ 11, was related to sleep disordered breathing. Clinicians should be alert to (1) differing perspectives of sleepiness for investigation and treatment of OSA, and (2) the presence of depression and nocturia in men presenting with significant Epworth sleepiness regardless of the presence of OSA.
Authors: Sowmya Krishnan; Ching Li Chai-Coetzer; Nicole Grivell; Nicole Lovato; Sutapa Mukherjee; Andrew Vakulin; Robert J Adams; Sarah L Appleton Journal: J Clin Sleep Med Date: 2022-07-01 Impact factor: 4.324
Authors: Sarah Appleton; Tiffany Gill; Anne Taylor; Douglas McEvoy; Zumin Shi; Catherine Hill; Amy Reynolds; Robert Adams Journal: Int J Environ Res Public Health Date: 2018-05-07 Impact factor: 3.390
Authors: Gerard Dunleavy; André Comiran Tonon; Ai Ping Chua; Yichi Zhang; Kei Long Cheung; Thuan-Quoc Thach; Yuri Rykov; Chee-Kiong Soh; Georgios Christopoulos; Hein de Vries; Josip Car Journal: Int J Environ Res Public Health Date: 2019-10-28 Impact factor: 3.390