Literature DB >> 2731231

A quantitative analysis of alterations in the shape of cultured fibroblasts induced by tumour-promoting phorbol ester.

A F Brown1, V Dugina, G A Dunn, J M Vasiliev.   

Abstract

Quantitative analysis of cell size and shape has shown that the tumour promotor 12-o-tetradecanoylphorbol-13-acetate (TPA) alters one of three parameters of cell shape, dispersion. It has no effect on cell area or elongation. This reflects the fact that TPA causes cells to form long narrow processes extending from the cell body. The ability to measure alterations in specific parameters of cell shape is important for correlating changes in the observed behaviour of cells with effects on cytoskeletal organisation.

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Year:  1989        PMID： 2731231     DOI： 10.1016/0309-1651(89)90162-8

Source DB:  PubMed          Journal:  Cell Biol Int Rep        ISSN： 0309-1651


  3 in total

1.  Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts.

Authors:  S Munevar; Y Wang ; M Dembo
Journal:  Biophys J       Date:  2001-04       Impact factor: 4.033

2.  A quantitative description of components of in vitro morphometric change in the rat osteoclast model: relationships with cellular function.

Authors:  M Zaidi; A S Alam; V S Shankar; B E Bax; B S Moonga; P J Bevis; M Pazianas; C L Huang
Journal:  Eur Biophys J       Date:  1992       Impact factor: 1.733

3.  Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain.

Authors:  V I Rodionov; F K Gyoeva; E Tanaka; A D Bershadsky; J M Vasiliev; V I Gelfand
Journal:  J Cell Biol       Date:  1993-12       Impact factor: 10.539
  3 in total

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