Baqiyyah Conway1, Karen E Innes2, Dustin Long3. 1. Department of Epidemiology, West Virginia University, P.O. Box 9127, Morgantown, WV 26505. Electronic address: bnconway@hsc.wvu.edu. 2. Department of Epidemiology, West Virginia University, P.O. Box 9127, Morgantown, WV 26505. 3. Department of Biostatistics, West Virginia University, P.O. Box 9127, Morgantown, WV 26505.
Abstract
AIMS: Perfluoroalkyl substances (PFAS) are synthetic hydrocarbons shown to preserve pancreatic islet cell viability and reduce islet cell hypoxia and apoptosis. We investigated the relationship of serum PFAS with diabetes, and whether this varied by diabetes type. METHODS: 6,460 individuals with and 60,439 without diabetes from the C8 Health Project, were categorized into three groups: type 1 (n=820), type 2 (n=4,291), or uncategorized diabetes (n=1,349, missing data on diabetes type or diabetes based on blood sugar at study entry). Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononaoic acid (PFNA). RESULTS: PFAS levels were significantly lower in those with diabetes, and lowest in those with type 1 diabetes. In age and sex adjusted analyses, ORs (CI) for type 1, type 2, and uncategorized diabetes compared to no diabetes were 0.59 (0.54-0.64), 0.74 (0.71-0.77), 0.84 (0.78-0.90), respectively for PFHxS; 0.69 (0.65-0.74), 0.87 (0.89-0.91), 0.92 (0.88-0.97), respectively for PFOA; 0.65 (0.61-0.70), 0.86 (0.82-0.90), 0.93 (0.86-1.03), respectively for PFOS; and 0.65 (0.57-0.74), 0.94 (0.88-1.00), 0.95 (0.85-1.06), respectively for PFNA. Further adjustment for eGFR and other covariates did not eliminate these inverse associations. CONCLUSIONS: PFAS levels were negatively associated with diabetes. This inverse relationship was strongest for type 1 diabetes, suggesting the relationship with serum PFAS may vary with the severity of islet cell deficiency.
AIMS: Perfluoroalkyl substances (PFAS) are synthetic hydrocarbons shown to preserve pancreatic islet cell viability and reduce islet cell hypoxia and apoptosis. We investigated the relationship of serum PFAS with diabetes, and whether this varied by diabetes type. METHODS: 6,460 individuals with and 60,439 without diabetes from the C8 Health Project, were categorized into three groups: type 1 (n=820), type 2 (n=4,291), or uncategorized diabetes (n=1,349, missing data on diabetes type or diabetes based on blood sugar at study entry). Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononaoic acid (PFNA). RESULTS:PFAS levels were significantly lower in those with diabetes, and lowest in those with type 1 diabetes. In age and sex adjusted analyses, ORs (CI) for type 1, type 2, and uncategorized diabetes compared to no diabetes were 0.59 (0.54-0.64), 0.74 (0.71-0.77), 0.84 (0.78-0.90), respectively for PFHxS; 0.69 (0.65-0.74), 0.87 (0.89-0.91), 0.92 (0.88-0.97), respectively for PFOA; 0.65 (0.61-0.70), 0.86 (0.82-0.90), 0.93 (0.86-1.03), respectively for PFOS; and 0.65 (0.57-0.74), 0.94 (0.88-1.00), 0.95 (0.85-1.06), respectively for PFNA. Further adjustment for eGFR and other covariates did not eliminate these inverse associations. CONCLUSIONS:PFAS levels were negatively associated with diabetes. This inverse relationship was strongest for type 1 diabetes, suggesting the relationship with serum PFAS may vary with the severity of islet cell deficiency.
Authors: E Maillard; M Sanchez-Dominguez; C Kleiss; A Langlois; M C Sencier; C Vodouhe; W Beitigier; M P Krafft; M Pinget; A Belcourt; S Sigrist Journal: Transplant Proc Date: 2008-03 Impact factor: 1.066
Authors: E Maillard; M T Juszczak; A Langlois; C Kleiss; M C Sencier; W Bietiger; M Sanchez-Dominguez; M P Krafft; P R V Johnson; M Pinget; S Sigrist Journal: Cell Transplant Date: 2011-09-22 Impact factor: 4.064
Authors: Kayoko Kato; Antonia M Calafat; Lee-Yang Wong; Amal A Wanigatunga; Samuel P Caudill; Larry L Needham Journal: Environ Sci Technol Date: 2009-04-01 Impact factor: 9.028
Authors: Stephanie J Frisbee; A Paul Brooks; Arthur Maher; Patsy Flensborg; Susan Arnold; Tony Fletcher; Kyle Steenland; Anoop Shankar; Sarah S Knox; Cecil Pollard; Joel A Halverson; Verónica M Vieira; Chuanfang Jin; Kevin M Leyden; Alan M Ducatman Journal: Environ Health Perspect Date: 2009-07-13 Impact factor: 9.031
Authors: Karilyn E Sant; Kate Annunziato; Sarah Conlin; Gregory Teicher; Phoebe Chen; Olivia Venezia; Gerald B Downes; Yeonhwa Park; Alicia R Timme-Laragy Journal: Environ Pollut Date: 2021-02-04 Impact factor: 8.071
Authors: Andres Cardenas; Diane R Gold; Russ Hauser; Ken P Kleinman; Marie-France Hivert; Antonia M Calafat; Xiaoyun Ye; Thomas F Webster; Edward S Horton; Emily Oken Journal: Environ Health Perspect Date: 2017-10-02 Impact factor: 9.031
Authors: Barbara Predieri; Patrizia Bruzzi; Elena Bigi; Silvia Ciancia; Simona F Madeo; Laura Lucaccioni; Lorenzo Iughetti Journal: Int J Mol Sci Date: 2020-04-22 Impact factor: 5.923