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Literature DB >> 27311313

PLAGL1: an important player in diverse pathological processes.

Ana F Vega-Benedetti¹, Cinthia Saucedo¹, Patrizia Zavattari², Roberta Vanni², José L Zugaza^3,4,5, Luis Antonio Parada⁶.

Abstract

The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses, but the molecular mechanisms by which the protein PLAGL1 participates in such diverse processes remains to be elucidated. In this review, we focus mainly on the molecular biology of PLAGL1 and the relevance of its abnormalities to several pathological processes.

Entities: Disease Gene

Keywords: Cancer; Diabetes; PLAGL1; Tumor suppressor gene

Mesh：

Substances：

Year: 2016 PMID： 27311313 DOI： 10.1007/s13353-016-0355-4

Source DB: PubMed Journal: J Appl Genet ISSN： 1234-1983 Impact factor: 3.240

48 in total

1. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1.

Authors: S M Huang; A H Schönthal; M R Stallcup
Journal: Oncogene Date: 2001-04-19 Impact factor: 9.867

2. Zac1 functional interactions mediate AP-1 transcriptional activity.

Authors: Wei-Ming Wang; Shu-Ting Liu; Shih-Ming Huang; Wei-Shiang Lin; Shyi-Gen Chen; Yung-Lung Chang
Journal: Biochim Biophys Acta Date: 2011-08-16

3. Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.

Authors: A Varrault; B Bilanges; D J Mackay; E Basyuk; B Ahr; C Fernandez; D O Robinson; J Bockaert; L Journot
Journal: J Biol Chem Date: 2001-04-10 Impact factor: 5.157

4. Down-regulation of Zac1 gene expression in rat white adipose tissue by androgens.

Authors: Agnieszka Mirowska; Tomasz Sledzinski; Ryszard T Smolenski; Julian Swierczynski
Journal: J Steroid Biochem Mol Biol Date: 2013-12-05 Impact factor: 4.292

5. Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.

Authors: A Abdollahi; D Roberts; A K Godwin; D C Schultz; G Sonoda; J R Testa; T C Hamilton
Journal: Oncogene Date: 1997-04-24 Impact factor: 9.867

6. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines.

Authors: G Piras; A El Kharroubi; S Kozlov; D Escalante-Alcalde; L Hernandez; N G Copeland; D J Gilbert; N A Jenkins; C L Stewart
Journal: Mol Cell Biol Date: 2000-05 Impact factor: 4.272

7. Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith-Wiedemann syndrome.

Authors: Jet Bliek; Gaetano Verde; Jonathan Callaway; Saskia M Maas; Agostina De Crescenzo; Angela Sparago; Flavia Cerrato; Silvia Russo; Serena Ferraiuolo; Maria Michela Rinaldi; Rita Fischetto; Faustina Lalatta; Lucio Giordano; Paola Ferrari; Maria Vittoria Cubellis; Lidia Larizza; I Karen Temple; Marcel M A M Mannens; Deborah J G Mackay; Andrea Riccio
Journal: Eur J Hum Genet Date: 2008-12-17 Impact factor: 4.246

8. Deregulation of an imprinted gene network in prostate cancer.

Authors: Teodora Ribarska; Wolfgang Goering; Johanna Droop; Klaus-Marius Bastian; Marc Ingenwerth; Wolfgang A Schulz
Journal: Epigenetics Date: 2014-02-10 Impact factor: 4.528

Review 9. Beckwith-Wiedemann and IMAGe syndromes: two very different diseases caused by mutations on the same gene.

Authors: Donatella Milani; Lidia Pezzani; Silvia Tabano; Monica Miozzo
Journal: Appl Clin Genet Date: 2014-09-16

10. Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.

Authors: Ilaria Baglivo; Sabrina Esposito; Lucia De Cesare; Angela Sparago; Zahra Anvar; Vincenzo Riso; Marco Cammisa; Roberto Fattorusso; Giovanna Grimaldi; Andrea Riccio; Paolo V Pedone
Journal: FEBS Lett Date: 2013-03-13 Impact factor: 4.124

12 in total

1. A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2.

Authors: Kyle D Pedro; Luis M Agosto; Jared A Sewell; Kimberly A Eberenz; Xianbao He; Juan I Fuxman Bass; Andrew J Henderson
Journal: Proc Natl Acad Sci U S A Date: 2021-03-16 Impact factor: 11.205

2. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

Authors: Caroline Goujon; Antoine Rebendenne; Priyanka Roy; Boris Bonaventure; Ana Chaves Valadao; Lowiese Desmarets; Yves Rouillé; Marine Tauziet; Mary Arnaud-Arnould; Donatella Giovannini; Yenarae Lee; Peter DeWeirdt; Mudra Hegde; Francisco Garcia de Gracia; Joe McKellar; Mélanie Wencker; Jean Dubuisson; Sandrine Belouzard; Olivier Moncorgé; John Doench
Journal: Res Sq Date: 2021-05-27

3. A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.

Authors: Claire E L Smith; Alexia Alexandraki; Sarah F Cordery; Rekha Parmar; David T Bonthron; Elizabeth M A Valleley
Journal: PLoS One Date: 2017-09-28 Impact factor: 3.240

PLAGL1: an important player in diverse pathological processes.

1. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1.

2. Zac1 functional interactions mediate AP-1 transcriptional activity.

3. Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.

4. Down-regulation of Zac1 gene expression in rat white adipose tissue by androgens.

5. Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.

6. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines.

7. Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith-Wiedemann syndrome.

8. Deregulation of an imprinted gene network in prostate cancer.

Review 9. Beckwith-Wiedemann and IMAGe syndromes: two very different diseases caused by mutations on the same gene.

10. Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.

1. A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2.

2. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

3. A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes.

4. Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.

Review 5. Imprinted Genes Impact Upon Beta Cell Function in the Current (and Potentially Next) Generation.

6. Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.

7. PLAGL1 gene function during hepatoma cells proliferation.

8. Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes.

Review 9. Imprinted Genes and Multiple Sclerosis: What Do We Know?

10. Impact of parental exercise on epigenetic modifications inherited by offspring: A systematic review.