Zhuan Zheng1, Xue-Jun Dong1. 1. a Clinical Laboratory Center of Shaoxing People's Hospital , Shaoxing Hospital of Zhejiang University , Shaoxing , China.
Abstract
OBJECTIVE: This study was to explore the clinical role of serum trophoblast cell surface protein 2 (TROP2) antibody in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We collected serum specimens from 117 NSCLC patients, 40 benign lung disease patients, and 60 healthy controls. TROP2 antibody concentrations were measured using enzyme-linked immunosorbent assay. RESULTS: Serum TROP2 antibody levels were higher in the NSCLC group compared to the control group (p < 0.001). TROP2 antibody, at a cutoff value of 9.8 U/ml, showed good diagnostic performance for NSCLC. CONCLUSION: Measurement of TROP2 antibody might have diagnostic value for patients with NSCLC.
OBJECTIVE: This study was to explore the clinical role of serum trophoblast cell surface protein 2 (TROP2) antibody in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We collected serum specimens from 117 NSCLCpatients, 40 benign lung diseasepatients, and 60 healthy controls. TROP2 antibody concentrations were measured using enzyme-linked immunosorbent assay. RESULTS: Serum TROP2 antibody levels were higher in the NSCLC group compared to the control group (p < 0.001). TROP2 antibody, at a cutoff value of 9.8 U/ml, showed good diagnostic performance for NSCLC. CONCLUSION: Measurement of TROP2 antibody might have diagnostic value for patients with NSCLC.