| Literature DB >> 2731041 |
M Kanje1, A Skottner, J Sjöberg, G Lundborg.
Abstract
The effect of insulin-like growth factor I (IGF-I) was tested on regeneration of the rat sciatic nerve after a crush lesion. IGF-I was administered via miniosmotic pumps to the dorsal root ganglia or locally around the crush lesion. Regeneration of sensory fibers was measured after 3 or 4 days superfusion by pinching. IGF-I stimulated regeneration in both administration paradigms. Regeneration was inhibited if the nerve was perfused with specific antibodies to native IGF-I. The results suggest that endogenous extracellular IGF-I plays an important role during regeneration of peripheral nerve fibers.Entities:
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Year: 1989 PMID： 2731041 DOI： 10.1016/0006-8993(89)90531-3
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252