Literature DB >> 2730892

Heterogeneity of cellular expression of arachidonate 15-lipoxygenase: implications for biological activity.

M J Holtzman1, A Pentland, N L Baenziger, J R Hansbrough.   

Abstract

Comparison of relative arachidonate 15-lipoxygenase activities in different types of human cell reveals striking differences in levels of product generation. Among available human cell types, the tracheal epithelial cell and the eosinophil have markedly higher levels of activity than other cell types with reported activity. Theories of functional significance for this enzymatic pathway will need to account for the selective expression of high levels of activity in a highly limited number of cell types.

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Year:  1989        PMID: 2730892     DOI: 10.1016/0005-2760(89)90257-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  7 in total

1.  Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

Authors:  M E Brezinski; C N Serhan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.

Authors:  J A Nadel; D J Conrad; I F Ueki; A Schuster; E Sigal
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

Review 3.  Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.

Authors:  William S Powell; Joshua Rokach
Journal:  Biochim Biophys Acta       Date:  2014-10-29

4.  A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells.

Authors:  M J Holtzman; J Turk; A Pentland
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

5.  Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.

Authors:  A P Pentland; M Mahoney; S C Jacobs; M J Holtzman
Journal:  J Clin Invest       Date:  1990-08       Impact factor: 14.808

6.  Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.

Authors:  V B O'Donnell; S Spycher; A Azzi
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

7.  Interferon-gamma induces the synthesis and activation of cytosolic phospholipase A2.

Authors:  T Wu; S J Levine; M G Lawrence; C Logun; C W Angus; J H Shelhamer
Journal:  J Clin Invest       Date:  1994-02       Impact factor: 14.808

  7 in total

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