Literature DB >> 27308636

Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia.

Tim D D Somerville1, Tim C P Somervaille1.   

Abstract

Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.

Entities:  

Keywords:  Acute myeloid leukemia; FOXC1; Polycomb

Year:  2016        PMID： 27308636      PMCID： PMC4905553          DOI： 10.1080/23723556.2015.1131355

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer.

Authors:  Partha S Ray; Jinhua Wang; Ying Qu; Myung-Shin Sim; Jaime Shamonki; Sanjay P Bagaria; Xing Ye; Bingya Liu; David Elashoff; Dave S Hoon; Michael A Walter; John W Martens; Andrea L Richardson; Armando E Giuliano; Xiaojiang Cui
Journal:  Cancer Res       Date:  2010-04-20       Impact factor: 12.701

2.  The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.

Authors:  Steven T Sizemore; Ruth A Keri
Journal:  J Biol Chem       Date:  2012-05-29       Impact factor: 5.157

3.  Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.

Authors:  Yoshiki Omatsu; Masanari Seike; Tatsuki Sugiyama; Tsutomu Kume; Takashi Nagasawa
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962

4.  Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

Authors:  Tim D D Somerville; Daniel H Wiseman; Gary J Spencer; Xu Huang; James T Lynch; Hui Sun Leong; Emma L Williams; Edmund Cheesman; Tim C P Somervaille
Journal:  Cancer Cell       Date:  2015-09-14       Impact factor: 31.743

5.  FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation.

Authors:  Kimberly A Aldinger; Ordan J Lehmann; Louanne Hudgins; Victor V Chizhikov; Alexander G Bassuk; Lesley C Ades; Ian D Krantz; William B Dobyns; Kathleen J Millen
Journal:  Nat Genet       Date:  2009-08-09       Impact factor: 38.330

Review 6.  Forkhead transcription factors: key players in health and disease.

Authors:  Bérénice A Benayoun; Sandrine Caburet; Reiner A Veitia
Journal:  Trends Genet       Date:  2011-04-18       Impact factor: 11.639

7.  The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25.

Authors:  D Y Nishimura; R E Swiderski; W L Alward; C C Searby; S R Patil; S R Bennet; A B Kanis; J M Gastier; E M Stone; V C Sheffield
Journal:  Nat Genet       Date:  1998-06       Impact factor: 38.330

8.  Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma.

Authors:  Limin Xia; Wenjie Huang; Dean Tian; Hongwu Zhu; Xingshun Qi; Zheng Chen; Yongguo Zhang; Hao Hu; Daiming Fan; Yongzhan Nie; Kaichun Wu
Journal:  Hepatology       Date:  2013-02       Impact factor: 17.425

9.  FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.

Authors:  Bingchen Han; Ying Qu; Yanli Jin; Yi Yu; Nan Deng; Kolja Wawrowsky; Xiao Zhang; Na Li; Shikha Bose; Qiang Wang; Sugunadevi Sakkiah; Ravinder Abrol; Tor W Jensen; Benjamin P Berman; Hisashi Tanaka; Jeffrey Johnson; Bowen Gao; Jijun Hao; Zhenqiu Liu; Ralph Buttyan; Partha S Ray; Mien-Chie Hung; Armando E Giuliano; Xiaojiang Cui
Journal:  Cell Rep       Date:  2015-11-03       Impact factor: 9.423

10.  The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.

Authors:  T Kume; K Y Deng; V Winfrey; D B Gould; M A Walter; B L Hogan
Journal:  Cell       Date:  1998-06-12       Impact factor: 41.582
  10 in total
  2 in total

1.  Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect.

Authors:  Jian-Hong Wu; Ke-Ning Sun; Zhi-Hao Chen; Yi-Jun He; Lu Sheng
Journal:  J Oncol       Date:  2022-01-19       Impact factor: 4.375

Review 2.  FOXC1, the new player in the cancer sandbox.

Authors:  Fahed A Elian; Elizabeth Yan; Michael A Walter
Journal:  Oncotarget       Date:  2017-11-28
  2 in total

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