Literature DB >> 27308634

A metabolic link between the urea cycle and cancer cell proliferation.

Sandesh C S Nagamani1, Ayelet Erez2.   

Abstract

Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.

Entities:  

Keywords:  Aspartate; argininosuccinate synthase; cancer metabolism; pyrimidine synthesis; urea cycle

Year:  2016        PMID： 27308634      PMCID： PMC4905422          DOI： 10.1080/23723556.2015.1127314

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  Global reconstruction of the human metabolic network based on genomic and bibliomic data.

Authors:  Natalie C Duarte; Scott A Becker; Neema Jamshidi; Ines Thiele; Monica L Mo; Thuy D Vo; Rohith Srivas; Bernhard Ø Palsson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-31       Impact factor: 11.205

2.  Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma.

Authors:  Eisuke Kobayashi; Mari Masuda; Robert Nakayama; Hitoshi Ichikawa; Reiko Satow; Miki Shitashige; Kazufumi Honda; Umio Yamaguchi; Ayako Shoji; Naobumi Tochigi; Hideo Morioka; Yoshiaki Toyama; Setsuo Hirohashi; Akira Kawai; Tesshi Yamada
Journal:  Mol Cancer Ther       Date:  2010-02-16       Impact factor: 6.261

3.  Integrative genome comparison of primary and metastatic melanomas.

Authors:  Omar Kabbarah; Cristina Nogueira; Bin Feng; Rosalynn M Nazarian; Marcus Bosenberg; Min Wu; Kenneth L Scott; Lawrence N Kwong; Yonghong Xiao; Carlos Cordon-Cardo; Scott R Granter; Sridhar Ramaswamy; Todd Golub; Lyn M Duncan; Stephan N Wagner; Cameron Brennan; Lynda Chin
Journal:  PLoS One       Date:  2010-05-24       Impact factor: 3.240

4.  Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.

Authors:  Yan Long; Wen-Bin Tsai; Medhi Wangpaichitr; Takashi Tsukamoto; Niramol Savaraj; Lynn G Feun; Macus Tien Kuo
Journal:  Mol Cancer Ther       Date:  2013-08-26       Impact factor: 6.261

Review 5.  Metabolic dysregulation in monogenic disorders and cancer - finding method in madness.

Authors:  Ayelet Erez; Ralph J DeBerardinis
Journal:  Nat Rev Cancer       Date:  2015-06-18       Impact factor: 69.800

6.  Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma.

Authors:  N Syed; J Langer; K Janczar; P Singh; C Lo Nigro; L Lattanzio; H M Coley; E Hatzimichael; J Bomalaski; P Szlosarek; M Awad; K O'Neil; F Roncaroli; T Crook
Journal:  Cell Death Dis       Date:  2013-01-17       Impact factor: 8.469

7.  Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.

Authors:  Shiran Rabinovich; Lital Adler; Keren Yizhak; Alona Sarver; Alon Silberman; Shani Agron; Noa Stettner; Qin Sun; Alexander Brandis; Daniel Helbling; Stanley Korman; Shalev Itzkovitz; David Dimmock; Igor Ulitsky; Sandesh Cs Nagamani; Eytan Ruppin; Ayelet Erez
Journal:  Nature       Date:  2015-11-11       Impact factor: 49.962
  7 in total
  14 in total

1.  A human cell atlas of fetal gene expression.

Authors:  Junyue Cao; Diana R O'Day; Hannah A Pliner; Paul D Kingsley; Mei Deng; Riza M Daza; Michael A Zager; Kimberly A Aldinger; Ronnie Blecher-Gonen; Fan Zhang; Malte Spielmann; James Palis; Dan Doherty; Frank J Steemers; Ian A Glass; Cole Trapnell; Jay Shendure
Journal:  Science       Date:  2020-11-13       Impact factor: 47.728

Review 2.  Clinical and biochemical footprints of inherited metabolic diseases. VIII. Neoplasias.

Authors:  Teodoro Jerves; Nenad Blau; Carlos R Ferreira
Journal:  Mol Genet Metab       Date:  2022-03-28       Impact factor: 4.204

3.  IntLIM: integration using linear models of metabolomics and gene expression data.

Authors:  Jalal K Siddiqui; Elizabeth Baskin; Mingrui Liu; Carmen Z Cantemir-Stone; Bofei Zhang; Russell Bonneville; Joseph P McElroy; Kevin R Coombes; Ewy A Mathé
Journal:  BMC Bioinformatics       Date:  2018-03-05       Impact factor: 3.169

4.  Autophagy maintains tumour growth through circulating arginine.

Authors:  Laura Poillet-Perez; Xiaoqi Xie; Le Zhan; Yang Yang; Daniel W Sharp; Zhixian Sherrie Hu; Xiaoyang Su; Anurag Maganti; Cherry Jiang; Wenyun Lu; Haiyan Zheng; Marcus W Bosenberg; Janice M Mehnert; Jessie Yanxiang Guo; Edmund Lattime; Joshua D Rabinowitz; Eileen White
Journal:  Nature       Date:  2018-11-14       Impact factor: 49.962

Review 5.  Role of tumor and host autophagy in cancer metabolism.

Authors:  Laura Poillet-Perez; Eileen White
Journal:  Genes Dev       Date:  2019-06-01       Impact factor: 11.361

6.  Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer.

Authors:  Yang Chen; Yun Gao; Xiaojiao Yi; Jinghui Zhang; Zhongjian Chen; Yongjiang Wu
Journal:  Front Pharmacol       Date:  2020-10-22       Impact factor: 5.810

7.  Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.

Authors:  Joo Sang Lee; Lital Adler; Hiren Karathia; Narin Carmel; Shiran Rabinovich; Noam Auslander; Rom Keshet; Noa Stettner; Alon Silberman; Lilach Agemy; Daniel Helbling; Raya Eilam; Qin Sun; Alexander Brandis; Sergey Malitsky; Maxim Itkin; Hila Weiss; Sivan Pinto; Shelly Kalaora; Ronen Levy; Eilon Barnea; Arie Admon; David Dimmock; Noam Stern-Ginossar; Avigdor Scherz; Sandesh C S Nagamani; Miguel Unda; David M Wilson; Ronit Elhasid; Arkaitz Carracedo; Yardena Samuels; Sridhar Hannenhalli; Eytan Ruppin; Ayelet Erez
Journal:  Cell       Date:  2018-08-09       Impact factor: 41.582

8.  Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.

Authors:  Hao Jia; Yuquan Yang; Mengying Li; Yimin Chu; Huan Song; Jie Zhang; Dan Zhang; Qun Zhang; Ying Xu; Jiamin Wang; Hong Xu; Xiuqun Zou; Haixia Peng; Zhaoyuan Hou
Journal:  EMBO Rep       Date:  2021-06-29       Impact factor: 9.071

9.  Serum-based metabolic alterations in patients with papillary thyroid carcinoma unveiled by non-targeted 1H-NMR metabolomics approach.

Authors:  Reyhaneh Farrokhi Yekta; Mostafa Rezaei Tavirani; Afsaneh Arefi Oskouie; Mohammad Reza Mohajeri-Tehrani; Ahmad Reza Soroush; Alireza Akbarzadeh Baghban
Journal:  Iran J Basic Med Sci       Date:  2018-11       Impact factor: 2.699

10.  Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.

Authors:  Lianqin Liu; Yuxin Sun; Yunxia Zhao; Qian Wang; Hua Guo; Rui Guo; Yanan Liu; Shuang Fu; Ling Zhang; Yang Li; Yan Meng
Journal:  Cancer Sci       Date:  2018-11-11       Impact factor: 6.716
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