Literature DB >> 27308630

More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells.

Christopher Heeschen1, Patricia Sancho1.   

Abstract

Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified a subset of CSCs with reduced mitochondrial content that showed resistance to mitochondrial targeting, but could be sensitized by inhibition of MYC.

Entities:  

Keywords:  Cancer stem cells; metabolism; metformin; pancreatic ductal adenocarcinoma

Year:  2016        PMID： 27308630      PMCID： PMC4905405          DOI： 10.1080/23723556.2015.1105353

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Intracellular autofluorescence: a biomarker for epithelial cancer stem cells.

Authors:  Irene Miranda-Lorenzo; Jorge Dorado; Enza Lonardo; Sonia Alcala; Alicia G Serrano; Jenifer Clausell-Tormos; Michele Cioffi; Diego Megias; Sladjana Zagorac; Anamaria Balic; Manuel Hidalgo; Mert Erkan; Joerg Kleeff; Aldo Scarpa; Bruno Sainz; Christopher Heeschen
Journal:  Nat Methods       Date:  2014-09-28       Impact factor: 28.547

2.  Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial.

Authors:  Sil Kordes; Michael N Pollak; Aeilko H Zwinderman; Ron A Mathôt; Mariëtte J Weterman; Aart Beeker; Cornelis J Punt; Dick J Richel; Johanna W Wilmink
Journal:  Lancet Oncol       Date:  2015-06-08       Impact factor: 41.316

3.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Authors:  Andrea Viale; Piergiorgio Pettazzoni; Costas A Lyssiotis; Haoqiang Ying; Nora Sánchez; Matteo Marchesini; Alessandro Carugo; Tessa Green; Sahil Seth; Virginia Giuliani; Maria Kost-Alimova; Florian Muller; Simona Colla; Luigi Nezi; Giannicola Genovese; Angela K Deem; Avnish Kapoor; Wantong Yao; Emanuela Brunetto; Ya'an Kang; Min Yuan; John M Asara; Y Alan Wang; Timothy P Heffernan; Alec C Kimmelman; Huamin Wang; Jason B Fleming; Lewis C Cantley; Ronald A DePinho; Giulio F Draetta
Journal:  Nature       Date:  2014-08-10       Impact factor: 49.962

Review 4.  Metabolic symbiosis in cancer: refocusing the Warburg lens.

Authors:  Erica C Nakajima; Bennett Van Houten
Journal:  Mol Carcinog       Date:  2012-01-06       Impact factor: 4.784

5.  MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

Authors:  Patricia Sancho; Emma Burgos-Ramos; Alejandra Tavera; Tony Bou Kheir; Petra Jagust; Matthieu Schoenhals; David Barneda; Katherine Sellers; Ramon Campos-Olivas; Osvaldo Graña; Catarina R Viera; Mariia Yuneva; Bruno Sainz; Christopher Heeschen
Journal:  Cell Metab       Date:  2015-09-10       Impact factor: 27.287

6.  Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.

Authors:  Patrick C Hermann; Stephan L Huber; Tanja Herrler; Alexandra Aicher; Joachim W Ellwart; Markus Guba; Christiane J Bruns; Christopher Heeschen
Journal:  Cell Stem Cell       Date:  2007-09-13       Impact factor: 24.633

7.  Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.

Authors:  M Guha; S Srinivasan; G Ruthel; A K Kashina; R P Carstens; A Mendoza; C Khanna; T Van Winkle; N G Avadhani
Journal:  Oncogene       Date:  2013-11-04       Impact factor: 9.867

8.  Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.

Authors:  Enza Lonardo; Michele Cioffi; Patricia Sancho; Yolanda Sanchez-Ripoll; Sara Maria Trabulo; Jorge Dorado; Anamaria Balic; Manuel Hidalgo; Christopher Heeschen
Journal:  PLoS One       Date:  2013-10-18       Impact factor: 3.240

9.  Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions.

Authors:  Erica C Nakajima; Charles Laymon; Matthew Oborski; Weizhou Hou; Lin Wang; Jennifer R Grandis; Robert L Ferris; James M Mountz; Bennett Van Houten
Journal:  PLoS One       Date:  2014-08-15       Impact factor: 3.240

10.  Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism.

Authors:  Luke Gammon; Adrian Biddle; Hannah K Heywood; Anne C Johannessen; Ian C Mackenzie
Journal:  PLoS One       Date:  2013-04-30       Impact factor: 3.240
  10 in total
  6 in total

1.  Rapid induction of pancreatic cancer cells to cancer stem cells via heterochromatin modulation.

Authors:  Zhengyan Xu; Yanjun Jia; Xiaoxi Huang; Nianhua Feng; Ying Li
Journal:  Cell Cycle       Date:  2018-07-25       Impact factor: 4.534

2.  Predictive Role of Temporal Changes in Intratumoral Metabolic Heterogeneity During Palliative Chemotherapy in Patients with Advanced Pancreatic Cancer: A Prospective Cohort Study.

Authors:  Shin Hye Yoo; Seo Young Kang; Gi Jeong Cheon; Do-Youn Oh; Yung-Jue Bang
Journal:  J Nucl Med       Date:  2019-06-14       Impact factor: 10.057

3.  Prospective evaluation of metabolic intratumoral heterogeneity in patients with advanced gastric cancer receiving palliative chemotherapy.

Authors:  Shin Hye Yoo; Seo Young Kang; Jeesun Yoon; Tae-Yong Kim; Gi Jeong Cheon; Do-Youn Oh
Journal:  Sci Rep       Date:  2021-01-12       Impact factor: 4.379

Review 4.  Mitochondrial determinants of chemoresistance.

Authors:  Ansooya Bokil; Patricia Sancho
Journal:  Cancer Drug Resist       Date:  2019-09-19

5.  Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells.

Authors:  Claudia Di Carlo; Bebiana C Sousa; Marcello Manfredi; Jessica Brandi; Elisa Dalla Pozza; Emilio Marengo; Marta Palmieri; Ilaria Dando; Michael J O Wakelam; Andrea F Lopez-Clavijo; Daniela Cecconi
Journal:  Sci Rep       Date:  2021-06-24       Impact factor: 4.379

Review 6.  The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer.

Authors:  Sandra Valle; Laura Martin-Hijano; Sonia Alcalá; Marta Alonso-Nocelo; Bruno Sainz
Journal:  Cancers (Basel)       Date:  2018-01-26       Impact factor: 6.639
  6 in total

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