Literature DB >> 27308629

Autophagy degrades hypoxia inducible factors.

Adela DePavia1, Eric Jonasch1, Xian-De Liu1.   

Abstract

Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.

Entities:  

Keywords:  CMA; HIF1α; HIFα; UPS; macroautophagy

Year:  2016        PMID： 27308629      PMCID： PMC4905411          DOI： 10.1080/23723556.2015.1104428

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy.

Authors:  João Vasco Ferreira; Hugo Fôfo; Eloy Bejarano; Carla Figueira Bento; José S Ramalho; Henrique Girão; Paulo Pereira
Journal:  Autophagy       Date:  2013-06-07       Impact factor: 16.016

2.  Pre-clinical evaluation of AZD-2014, a novel mTORC1/2 dual inhibitor, against renal cell carcinoma.

Authors:  Bing Zheng; Jia-Hui Mao; Lin Qian; Hua Zhu; Dong-hua Gu; Xiao-dong Pan; Fang Yi; Dong-mei Ji
Journal:  Cancer Lett       Date:  2014-11-12       Impact factor: 8.679

3.  Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation.

Authors:  Maimon E Hubbi; Hongxia Hu; Ishrat Ahmed; Andre Levchenko; Gregg L Semenza
Journal:  J Biol Chem       Date:  2013-03-01       Impact factor: 5.157

Review 4.  HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.

Authors:  Brian Keith; Randall S Johnson; M Celeste Simon
Journal:  Nat Rev Cancer       Date:  2011-12-15       Impact factor: 60.716

5.  K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy.

Authors:  Joao Vasco Ferreira; Ana Rosa Soares; Jose Silva Ramalho; Paulo Pereira; Henrique Girao
Journal:  Sci Rep       Date:  2015-05-11       Impact factor: 4.379

6.  Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.

Authors:  X-D Liu; J Yao; D N Tripathi; Z Ding; Y Xu; M Sun; J Zhang; S Bai; P German; A Hoang; L Zhou; D Jonasch; X Zhang; C J Conti; E Efstathiou; N M Tannir; N T Eissa; G B Mills; C L Walker; E Jonasch
Journal:  Oncogene       Date:  2014-07-07       Impact factor: 9.867

7.  Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma.

Authors:  Xiao-Wen Liu; Tian-Yu Cai; Hong Zhu; Ji Cao; Yi Su; Yong-Zhou Hu; Qiao-Jun He; Bo Yang
Journal:  Autophagy       Date:  2013-11-11       Impact factor: 16.016
  7 in total
  6 in total

1.  Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.

Authors:  L Masuelli; M Granato; M Benvenuto; R Mattera; R Bernardini; M Mattei; G d'Amati; G D'Orazi; A Faggioni; R Bei; M Cirone
Journal:  Oncoimmunology       Date:  2017-07-31       Impact factor: 8.110

2.  Cryptochromes Suppress HIF1α in Muscles.

Authors:  Megan E Vaughan; Martina Wallace; Michal K Handzlik; Alanna B Chan; Christian M Metallo; Katja A Lamia
Journal:  iScience       Date:  2020-07-03

Review 3.  Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences.

Authors:  Mara Cirone; Maria Saveria Gilardini Montani; Marisa Granato; Alessia Garufi; Alberto Faggioni; Gabriella D'Orazi
Journal:  J Exp Clin Cancer Res       Date:  2019-06-14

4.  DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.

Authors:  Yan Cao; Rongyang Li; Ming Shen; Chengyu Li; Yan Zou; Qiang Jiang; Shuo Liu; Chunwan Lu; Honglin Li; Honglin Liu; Yafei Cai
Journal:  Cell Death Dis       Date:  2021-04-20       Impact factor: 8.469

5.  TFEB is a master regulator of tumor-associated macrophages in breast cancer.

Authors:  Yong Li; Johnie Hodge; Qing Liu; Junfeng Wang; Yuzhen Wang; Trent D Evans; Diego Altomare; Yongzhong Yao; E Angela Murphy; Babak Razani; Daping Fan
Journal:  J Immunother Cancer       Date:  2020-06       Impact factor: 13.751

Review 6.  Hypoxia and Selective Autophagy in Cancer Development and Therapy.

Authors:  Ioanna Daskalaki; Ilias Gkikas; Nektarios Tavernarakis
Journal:  Front Cell Dev Biol       Date:  2018-09-10
  6 in total

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