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Literature DB >> 27308626

Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma.

Jean-Charles Nault¹, Shalini Datta², Sandrine Imbeaud², Andrea Franconi², Jessica Zucman-Rossi³.

Abstract

Adeno-associated virus type 2 (AAV2) is a defective DNA virus that was previously considered to be non-pathogenic. We identified somatic AAV2 integration in a subset of 11 hepatocellular carcinomas (HCC) that mainly developed in normal liver without known etiology through recurrent insertional mutagenesis in cancer driver genes such as telomerase reverse transcriptase (TERT), cyclin A2 (CCNA2), cyclin E1 (CCNE1), tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), and lysine (K)-specific methyltransferase 2B (KMT2B).

Entities: Disease Species

Keywords: Adeno-associated virus type 2; TERT; gene therapy; hepatocellular carcinoma; insertional mutagenesis

Year: 2016 PMID： 27308626 PMCID： PMC4905403 DOI： 10.1080/23723556.2015.1095271

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. Mechanisms of HBV-related hepatocarcinogenesis.

Authors: Christine Neuveut; Yu Wei; Marie Annick Buendia
Journal: J Hepatol Date: 2010-01-07 Impact factor: 25.083

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Journal: Nat Genet Date: 2012-05-27 Impact factor: 38.330

Review 3. Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.

Authors: Jessica Zucman-Rossi; Augusto Villanueva; Jean-Charles Nault; Josep M Llovet
Journal: Gastroenterology Date: 2015-06-20 Impact factor: 22.682

Review 4. Why do viruses cause cancer? Highlights of the first century of human tumour virology.

Authors: Patrick S Moore; Yuan Chang
Journal: Nat Rev Cancer Date: 2010-11-24 Impact factor: 60.716

5. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.

Authors: Jean-Charles Nault; Shalini Datta; Sandrine Imbeaud; Andrea Franconi; Maxime Mallet; Gabrielle Couchy; Eric Letouzé; Camilla Pilati; Benjamin Verret; Jean-Frédéric Blanc; Charles Balabaud; Julien Calderaro; Alexis Laurent; Mélanie Letexier; Paulette Bioulac-Sage; Fabien Calvo; Jessica Zucman-Rossi
Journal: Nat Genet Date: 2015-08-24 Impact factor: 38.330

6. AAV vector integration sites in mouse hepatocellular carcinoma.

Authors: Anthony Donsante; Daniel G Miller; Yi Li; Carole Vogler; Elizabeth M Brunt; David W Russell; Mark S Sands
Journal: Science Date: 2007-07-27 Impact factor: 47.728

7. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

Authors: Jean Charles Nault; Maxime Mallet; Camilla Pilati; Julien Calderaro; Paulette Bioulac-Sage; Christophe Laurent; Alexis Laurent; Daniel Cherqui; Charles Balabaud; Jessica Zucman-Rossi; Jessica Zucman Rossi
Journal: Nat Commun Date: 2013 Impact factor: 14.919

8. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.

Authors: Amit C Nathwani; Edward G D Tuddenham; Savita Rangarajan; Cecilia Rosales; Jenny McIntosh; David C Linch; Pratima Chowdary; Anne Riddell; Arnulfo Jaquilmac Pie; Chris Harrington; James O'Beirne; Keith Smith; John Pasi; Bertil Glader; Pradip Rustagi; Catherine Y C Ng; Mark A Kay; Junfang Zhou; Yunyu Spence; Christopher L Morton; James Allay; John Coleman; Susan Sleep; John M Cunningham; Deokumar Srivastava; Etiena Basner-Tschakarjan; Federico Mingozzi; Katherine A High; John T Gray; Ulrike M Reiss; Arthur W Nienhuis; Andrew M Davidoff
Journal: N Engl J Med Date: 2011-12-10 Impact factor: 176.079

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Authors: Manuel A F V Gonçalves
Journal: Virol J Date: 2005-05-06 Impact factor: 4.099

10. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

Authors: Kornelius Schulze; Sandrine Imbeaud; Eric Letouzé; Ludmil B Alexandrov; Julien Calderaro; Sandra Rebouissou; Gabrielle Couchy; Clément Meiller; Jayendra Shinde; Frederic Soysouvanh; Anna-Line Calatayud; Roser Pinyol; Laura Pelletier; Charles Balabaud; Alexis Laurent; Jean-Frederic Blanc; Vincenzo Mazzaferro; Fabien Calvo; Augusto Villanueva; Jean-Charles Nault; Paulette Bioulac-Sage; Michael R Stratton; Josep M Llovet; Jessica Zucman-Rossi
Journal: Nat Genet Date: 2015-03-30 Impact factor: 38.330

10 in total

6 in total

Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma.

Review 1. Mechanisms of HBV-related hepatocarcinogenesis.

2. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.

Review 3. Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.

Review 4. Why do viruses cause cancer? Highlights of the first century of human tumour virology.

5. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.

6. AAV vector integration sites in mouse hepatocellular carcinoma.

7. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

8. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.

Review 9. Adeno-associated virus: from defective virus to effective vector.

10. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

1. AAV Infection: Protection from Cancer.

Review 2. Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention.

3. High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells.

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6. Mut2Vec: distributed representation of cancerous mutations.