Literature DB >> 27308624

Ras and p53: An unsuspected liaison.

Matthias Drosten1, Mariano Barbacid1.   

Abstract

The precise mechanism by which Ras proteins mediate mitogenic signaling remains obscure. We have identified the p53/p21Cip1 axis as an essential component of the Ras mitogenic pathway. Moreover, cells carrying an inactive p53/p21Cip1/Rb pathway sustain cell proliferation by inducing retroactivation of the MAPK signaling cascade in a Ras-independent manner.

Entities:  

Keywords:  MAPK signaling cascade; P21; Ras; Rb; cell cycle; p53

Year:  2015        PMID： 27308624      PMCID： PMC4905429          DOI： 10.1080/23723556.2014.996001

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  RAS oncogenes: the first 30 years.

Authors:  Marcos Malumbres; Mariano Barbacid
Journal:  Nat Rev Cancer       Date:  2003-06       Impact factor: 60.716

Review 2.  RAS and RHO GTPases in G1-phase cell-cycle regulation.

Authors:  Mathew L Coleman; Christopher J Marshall; Michael F Olson
Journal:  Nat Rev Mol Cell Biol       Date:  2004-05       Impact factor: 94.444

3.  ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry.

Authors:  Katya Korotayev; Marie Chaussepied; Doron Ginsberg
Journal:  Cell Signal       Date:  2008-02-21       Impact factor: 4.315

4.  Ras signaling is essential for skin development.

Authors:  M Drosten; C G Lechuga; M Barbacid
Journal:  Oncogene       Date:  2013-07-08       Impact factor: 9.867

5.  Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein.

Authors:  D S Peeper; T M Upton; M H Ladha; E Neuman; J Zalvide; R Bernards; J A DeCaprio; M E Ewen
Journal:  Nature       Date:  1997-03-13       Impact factor: 49.962

6.  Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

Authors:  Matthias Drosten; Alma Dhawahir; Eleanor Y M Sum; Jelena Urosevic; Carmen G Lechuga; Luis M Esteban; Esther Castellano; Carmen Guerra; Eugenio Santos; Mariano Barbacid
Journal:  EMBO J       Date:  2010-02-11       Impact factor: 11.598

7.  Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.

Authors:  Nidhi Sharma; Cynthia Timmers; Prashant Trikha; Harold I Saavedra; Amanda Obery; Gustavo Leone
Journal:  J Biol Chem       Date:  2006-09-27       Impact factor: 5.157

Review 8.  RAS oncogenes: weaving a tumorigenic web.

Authors:  Yuliya Pylayeva-Gupta; Elda Grabocka; Dafna Bar-Sagi
Journal:  Nat Rev Cancer       Date:  2011-10-13       Impact factor: 60.716

9.  Allosteric activation of functionally asymmetric RAF kinase dimers.

Authors:  Jiancheng Hu; Edward C Stites; Haiyang Yu; Elizabeth A Germino; Hiruy S Meharena; Philip J S Stork; Alexandr P Kornev; Susan S Taylor; Andrey S Shaw
Journal:  Cell       Date:  2013-08-29       Impact factor: 41.582

10.  Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Authors:  Matthias Drosten; Eleanor Y M Sum; Carmen G Lechuga; Lucía Simón-Carrasco; Harrys K C Jacob; Raquel García-Medina; Sidong Huang; Roderick L Beijersbergen; Rene Bernards; Mariano Barbacid
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-06       Impact factor: 11.205
  10 in total

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