Literature DB >> 27308608

Mitochondrial respiratory defects promote the Warburg effect and cancer progression.

Satish Srinivasan1, Manti Guha1, Narayan G Avadhani1.   

Abstract

In the past decade mitochondria have emerged as an important cellular signaling hub controlling metabolism, epigenetics, and cell fate. Dysfunctional mitochondria initiate a retrograde nuclear response that influences the cellular reprograming observed in various human pathologies, including cancer. New data suggest that loss of cytochrome c oxidase function promotes the Warburg effect and upregulates several genes with roles in tumor development.

Entities:  

Keywords:  Cancer; cytochrome oxidase; mitochondrial dysfunction; retrograde signaling

Year:  2015        PMID： 27308608      PMCID： PMC4905388          DOI： 10.1080/23723556.2015.1085120

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Mitochondrial signaling: the retrograde response.

Authors:  Ronald A Butow; Narayan G Avadhani
Journal:  Mol Cell       Date:  2004-04-09       Impact factor: 17.970

2.  A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase.

Authors:  Ida Namslauer; Peter Brzezinski
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-13       Impact factor: 11.205

Review 3.  Mitochondrial DNA mutations in human cancer.

Authors:  A Chatterjee; E Mambo; D Sidransky
Journal:  Oncogene       Date:  2006-08-07       Impact factor: 9.867

4.  Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen.

Authors:  Brandie N Radde; Margarita M Ivanova; Huy Xuan Mai; Joshua K Salabei; Bradford G Hill; Carolyn M Klinge
Journal:  Biochem J       Date:  2015-01-01       Impact factor: 3.857

5.  Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion.

Authors:  Corina van Waveren; Yubo Sun; Herman S Cheung; Carlos T Moraes
Journal:  Carcinogenesis       Date:  2005-10-12       Impact factor: 4.944

6.  Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation.

Authors:  Lokendra Kumar Sharma; Hezhi Fang; Jiangtao Liu; Rasika Vartak; Janice Deng; Yidong Bai
Journal:  Hum Mol Genet       Date:  2011-09-02       Impact factor: 6.150

7.  ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Authors:  Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi
Journal:  Science       Date:  2008-04-03       Impact factor: 47.728

Review 8.  Cytochrome c oxidase dysfunction in oxidative stress.

Authors:  Satish Srinivasan; Narayan G Avadhani
Journal:  Free Radic Biol Med       Date:  2012-07-25       Impact factor: 7.376

Review 9.  Mitochondria and cancer.

Authors:  Douglas C Wallace
Journal:  Nat Rev Cancer       Date:  2012-10       Impact factor: 60.716

10.  Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.

Authors:  S Srinivasan; M Guha; D W Dong; K A Whelan; G Ruthel; Y Uchikado; S Natsugoe; H Nakagawa; N G Avadhani
Journal:  Oncogene       Date:  2015-07-06       Impact factor: 9.867
  10 in total
  6 in total

1.  Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis.

Authors:  Sun Mi Hong; Young-Kyoung Lee; Imkyong Park; So Mee Kwon; Seongki Min; Gyesoon Yoon
Journal:  J Biol Chem       Date:  2019-03-28       Impact factor: 5.157

Review 2.  Role of the mitochondrial stress response in human cancer progression.

Authors:  Sheng-Fan Wang; Shiuan Chen; Ling-Ming Tseng; Hsin-Chen Lee
Journal:  Exp Biol Med (Maywood)       Date:  2020-04-23

3.  Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis.

Authors:  Jiao Mu; Yiyuan Tian; Fengzhou Liu; Zijun Wang; Rui Tan; Bei Zhang; Penghe Quan; Hongxin Zhang; Jingyue Yang; Peng Yuan
Journal:  J Cell Commun Signal       Date:  2021-11-25       Impact factor: 5.908

Review 4.  Insulin, insulin receptors, and cancer.

Authors:  R Vigneri; I D Goldfine; L Frittitta
Journal:  J Endocrinol Invest       Date:  2016-07-01       Impact factor: 4.256

5.  Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype.

Authors:  Martina Jackson; Nicole Serada; Maura Sheehan; Satish Srinivasan; Nicola Mason; Manti Guha; Narayan Avadhani
Journal:  PLoS One       Date:  2018-12-21       Impact factor: 3.240

Review 6.  Metabolic Plasticity in Chemotherapy Resistance.

Authors:  Maria Andrea Desbats; Isabella Giacomini; Tommaso Prayer-Galetti; Monica Montopoli
Journal:  Front Oncol       Date:  2020-03-06       Impact factor: 6.244
  6 in total

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