Literature DB >> 27308604

A MYCN-MRN complex axis controls replication stress for the safe expansion of neuroprogenitor cells.

Marialaura Petroni1, Giuseppe Giannini2.   

Abstract

DNA replication must be tightly regulated to ensure accurate duplication of the genome and its transfer to the daughter cells. When these regulatory mechanisms fail, replicative stress and DNA damage ensue, eventually leading to cell cycle inhibition or cell death. We have recently uncovered that MYCN-dependent expansion of neuroprogenitor cells is accompanied by replication stress, which is restrained by the MRN complex, a direct transcriptional target of the MYCN proto-oncogene.

Entities:  

Keywords:  DNA damage response; DNA replication; MRN complex; N-myc; Neuroprogenitor cells; Replication stress; microcephaly; proto-oncogene

Year:  2015        PMID： 27308604      PMCID： PMC4905383          DOI： 10.1080/23723556.2015.1079673

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The essential function of the MRN complex in the resolution of endogenous replication intermediates.

Authors:  Christopher Bruhn; Zhong-Wei Zhou; Haiyan Ai; Zhao-Qi Wang
Journal:  Cell Rep       Date:  2014-01-02       Impact factor: 9.423

2.  N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.

Authors:  Paul S Knoepfler; Pei Feng Cheng; Robert N Eisenman
Journal:  Genes Dev       Date:  2002-10-15       Impact factor: 11.361

Review 3.  The MRE11 complex: starting from the ends.

Authors:  Travis H Stracker; John H J Petrini
Journal:  Nat Rev Mol Cell Biol       Date:  2011-02       Impact factor: 94.444

4.  An essential function for NBS1 in the prevention of ataxia and cerebellar defects.

Authors:  Pierre-Olivier Frappart; Wei-Min Tong; Ilja Demuth; Ivan Radovanovic; Zdenko Herceg; Adriano Aguzzi; Martin Digweed; Zhao-Qi Wang
Journal:  Nat Med       Date:  2005-04-10       Impact factor: 53.440

Review 5.  Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

Authors:  Julien Lafrance-Vanasse; Gareth J Williams; John A Tainer
Journal:  Prog Biophys Mol Biol       Date:  2015-01-07       Impact factor: 3.667

6.  Genotype-phenotype correlations in MYCN-related Feingold syndrome.

Authors:  Carlo L M Marcelis; Frans A Hol; Gail E Graham; Paul N M A Rieu; Richard Kellermayer; Rowdy P P Meijer; Dorien Lugtenberg; Hans Scheffer; Hans van Bokhoven; Han G Brunner; Arjan P M de Brouwer
Journal:  Hum Mutat       Date:  2008-09       Impact factor: 4.878

Review 7.  Myc induced replicative stress response: How to cope with it and exploit it.

Authors:  Sara Rohban; Stefano Campaner
Journal:  Biochim Biophys Acta       Date:  2014-04-13

Review 8.  Maintaining genome stability in the nervous system.

Authors:  Peter J McKinnon
Journal:  Nat Neurosci       Date:  2013-10-28       Impact factor: 24.884

Review 9.  Nijmegen breakage syndrome (NBS).

Authors:  Krystyna H Chrzanowska; Hanna Gregorek; Bożenna Dembowska-Bagińska; Maria A Kalina; Martin Digweed
Journal:  Orphanet J Rare Dis       Date:  2012-02-28       Impact factor: 4.123

10.  The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.

Authors:  M Petroni; F Sardina; C Heil; M Sahún-Roncero; V Colicchia; V Veschi; S Albini; D Fruci; B Ricci; A Soriani; L Di Marcotullio; I Screpanti; A Gulino; G Giannini
Journal:  Cell Death Differ       Date:  2015-06-12       Impact factor: 15.828
  10 in total
  7 in total

Review 1.  Medulloblastoma and the DNA Damage Response.

Authors:  Leon F McSwain; Kiran K Parwani; Shubin W Shahab; Dolores Hambardzumyan; Tobey J MacDonald; Jennifer M Spangle; Anna Marie Kenney
Journal:  Front Oncol       Date:  2022-06-07       Impact factor: 5.738

2.  SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.

Authors:  Marialaura Petroni; Maria Sahùn Roncero; Valentina Ramponi; Francesca Fabretti; Vittoria Nicolis Di Robilant; Marta Moretti; Vincenzo Alfano; Alessandro Corsi; Simone De Panfilis; Maria Giubettini; Stefano Di Giulio; Carlo Capalbo; Francesca Belardinilli; Anna Coppa; Francesca Sardina; Valeria Colicchia; Flaminia Pedretti; Paola Infante; Beatrice Cardinali; Alessandra Tessitore; Gianluca Canettieri; Enrico De Smaele; Giuseppe Giannini
Journal:  Sci Rep       Date:  2019-12-23       Impact factor: 4.379

3.  Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN.

Authors:  Chunyu Pan; Yuyan Zhu; Meng Yu; Yongkang Zhao; Changsheng Zhang; Xizhe Zhang; Yang Yao
Journal:  Front Oncol       Date:  2021-04-21       Impact factor: 6.244

4.  A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.

Authors:  Marialaura Petroni; Francesca Fabretti; Stefano Di Giulio; Vittoria Nicolis di Robilant; Veronica La Monica; Marta Moretti; Francesca Belardinilli; Francesca Bufalieri; Anna Coppa; Paola Paci; Alessandro Corsi; Enrico De Smaele; Sonia Coni; Gianluca Canettieri; Lucia Di Marcotullio; Zhao-Qi Wang; Giuseppe Giannini
Journal:  Neuropathol Appl Neurobiol       Date:  2022-08-10       Impact factor: 6.250

Review 5.  Beyond the Warburg Effect: N-Myc Contributes to Metabolic Reprogramming in Cancer Cells.

Authors:  Go J Yoshida
Journal:  Front Oncol       Date:  2020-05-27       Impact factor: 6.244

6.  MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.

Authors:  Marialaura Petroni; Francesca Sardina; Paola Infante; Armando Bartolazzi; Erica Locatelli; Francesca Fabretti; Stefano Di Giulio; Carlo Capalbo; Beatrice Cardinali; Anna Coppa; Alessandra Tessitore; Valeria Colicchia; Maria Sahùn Roncero; Francesca Belardinilli; Lucia Di Marcotullio; Silvia Soddu; Mauro Comes Franchini; Elena Petricci; Alberto Gulino; Giuseppe Giannini
Journal:  Cell Death Dis       Date:  2018-08-30       Impact factor: 8.469

7.  A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.

Authors:  Stefano Di Giulio; Valeria Colicchia; Fabio Pastorino; Flaminia Pedretti; Francesca Fabretti; Vittoria Nicolis di Robilant; Valentina Ramponi; Giorgia Scafetta; Marta Moretti; Valerio Licursi; Francesca Belardinilli; Giovanna Peruzzi; Paola Infante; Bianca Maria Goffredo; Anna Coppa; Gianluca Canettieri; Armando Bartolazzi; Mirco Ponzoni; Giuseppe Giannini; Marialaura Petroni
Journal:  Oncogene       Date:  2021-09-10       Impact factor: 9.867
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.