Literature DB >> 27308600

Mitochondrial survivin - an Achilles' heel in cancer chemoresistance.

Michael J Ausserlechner1, Judith Hagenbuchner2.   

Abstract

The metabolic shift from oxidative phosphorylation to glycolysis as a hallmark of highly aggressive cancer was postulated by Otto Warburg in the 1920s. We identified baculoviral IAP repeat-containing 5 (BIRC5, also known as survivin) as a key player in mitochondrial metabolism and our recent findings suggest glycolysis inhibitors as powerful agents to overcome the antiapoptotic function of survivin in neuroblastoma.

Entities:  

Keywords:  Autophagy; Warburg effect; glycolysis inhibitors; mitochondria; neuroblastoma

Year:  2015        PMID： 27308600      PMCID： PMC4905378          DOI： 10.1080/23723556.2015.1076589

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  An IAP-IAP complex inhibits apoptosis.

Authors:  Takehiko Dohi; Kazuya Okada; Fang Xia; Casey E Wilford; Temesgen Samuel; Kate Welsh; Hiroyouki Marusawa; Hua Zou; Robert Armstrong; Shu-ichi Matsuzawa; Guy S Salvesen; John C Reed; Dario C Altieri
Journal:  J Biol Chem       Date:  2004-06-24       Impact factor: 5.157

2.  Selective escape of proteins from the mitochondria during mitophagy.

Authors:  Shotaro Saita; Michiko Shirane; Keiichi I Nakayama
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

3.  BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma.

Authors:  J Hagenbuchner; U Kiechl-Kohlendorfer; P Obexer; M J Ausserlechner
Journal:  Oncogene       Date:  2015-07-06       Impact factor: 9.867

4.  BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery.

Authors:  J Hagenbuchner; A V Kuznetsov; P Obexer; M J Ausserlechner
Journal:  Oncogene       Date:  2012-11-12       Impact factor: 9.867

5.  High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma.

Authors:  A Islam; H Kageyama; N Takada; T Kawamoto; H Takayasu; E Isogai; M Ohira; K Hashizume; H Kobayashi; Y Kaneko; A Nakagawara
Journal:  Oncogene       Date:  2000-02-03       Impact factor: 9.867

6.  Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited.

Authors:  Robert Stern; Svetlana Shuster; Birgit A Neudecker; Bent Formby
Journal:  Exp Cell Res       Date:  2002-05-15       Impact factor: 3.905

7.  Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis.

Authors:  Petra Obexer; Judith Hagenbuchner; Thomas Unterkircher; Nora Sachsenmaier; Christoph Seifarth; Günther Böck; Verena Porto; Kathrin Geiger; Michael Ausserlechner
Journal:  Mol Biol Cell       Date:  2009-02-11       Impact factor: 4.138

8.  Mitochondria and FOXO3: breath or die.

Authors:  Judith Hagenbuchner; Michael J Ausserlechner
Journal:  Front Physiol       Date:  2013-06-20       Impact factor: 4.566

Review 9.  Survivin as a preferential target for cancer therapy.

Authors:  Mahsa Mobahat; Aru Narendran; Karl Riabowol
Journal:  Int J Mol Sci       Date:  2014-02-13       Impact factor: 5.923
  9 in total
  6 in total

Review 1.  Survivin at a glance.

Authors:  Sally P Wheatley; Dario C Altieri
Journal:  J Cell Sci       Date:  2019-04-04       Impact factor: 5.285

Review 2.  Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs).

Authors:  Rama Rathore; Jennifer E McCallum; Elizabeth Varghese; Ana-Maria Florea; Dietrich Büsselberg
Journal:  Apoptosis       Date:  2017-07       Impact factor: 4.677

3.  The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma.

Authors:  Judith Hagenbuchner; Lorena Lungkofler; Ursula Kiechl-Kohlendorfer; Giampietro Viola; Maria Grazia Ferlin; Michael J Ausserlechner; Petra Obexer
Journal:  Oncotarget       Date:  2017-05-09

4.  Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.

Authors:  Xu Ji; Xing Guo; Yan Wang; Xiaotian Li; Hong Li
Journal:  Onco Targets Ther       Date:  2020-05-13       Impact factor: 4.147

5.  Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.

Authors:  Julie A MacDonald; Niharika Kura; Carleigh Sussman; Dori C Woods
Journal:  J Ovarian Res       Date:  2018-10-16       Impact factor: 4.234

Review 6.  Survivin-Based Treatment Strategies for Squamous Cell Carcinoma.

Authors:  Andrea Santarelli; Marco Mascitti; Lucio Lo Russo; Davide Sartini; Giuseppe Troiano; Monica Emanuelli; Lorenzo Lo Muzio
Journal:  Int J Mol Sci       Date:  2018-03-24       Impact factor: 5.923
  6 in total

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