Literature DB >> 27308594

CHCHD4 links AIF to the biogenesis of respiratory chain complex I.

Nazanine Modjtahedi1, Guido Kroemer2.   

Abstract

During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes.

Entities:  

Keywords:  Disulfide relay; mitochondrial import; mitochondriopathy; respiratory chain complexes

Year:  2015        PMID： 27308594      PMCID： PMC4905392          DOI： 10.1080/23723556.2015.1074332

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  A human mitochondriopathy caused by AIF mutation.

Authors:  N Modjtahedi; F Giordanetto; G Kroemer
Journal:  Cell Death Differ       Date:  2010-10       Impact factor: 15.828

2.  Genome-wide analysis of eukaryotic twin CX9C proteins.

Authors:  Gabriele Cavallaro
Journal:  Mol Biosyst       Date:  2010-10-04

3.  Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing.

Authors:  Itai Berger; Ziva Ben-Neriah; Talia Dor-Wolman; Avraham Shaag; Ann Saada; Shamir Zenvirt; Annick Raas-Rothschild; Michel Nadjari; Klaus H Kaestner; Orly Elpeleg
Journal:  Mol Genet Metab       Date:  2011-09-24       Impact factor: 4.797

4.  Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.

Authors:  Emilie Hangen; Olivier Féraud; Sylvie Lachkar; Haiwei Mou; Nunzianna Doti; Gian Maria Fimia; Ngoc-Vy Lam; Changlian Zhu; Isabelle Godin; Kevin Muller; Afroditi Chatzi; Esther Nuebel; Fabiola Ciccosanti; Stéphane Flamant; Paule Bénit; Jean-Luc Perfettini; Allan Sauvat; Annelise Bennaceur-Griscelli; Karine Ser-Le Roux; Patrick Gonin; Kostas Tokatlidis; Pierre Rustin; Mauro Piacentini; Menotti Ruvo; Klas Blomgren; Guido Kroemer; Nazanine Modjtahedi
Journal:  Mol Cell       Date:  2015-05-21       Impact factor: 17.970

Review 5.  Three approaches to one problem: protein folding in the periplasm, the endoplasmic reticulum, and the intermembrane space.

Authors:  Johannes M Herrmann; Jan Riemer
Journal:  Antioxid Redox Signal       Date:  2014-03-06       Impact factor: 8.401

Review 6.  Life with or without AIF.

Authors:  Emilie Hangen; Klas Blomgren; Paule Bénit; Guido Kroemer; Nazanine Modjtahedi
Journal:  Trends Biochem Sci       Date:  2010-02-06       Impact factor: 13.807

Review 7.  Human mitochondrial DNA: roles of inherited and somatic mutations.

Authors:  Eric A Schon; Salvatore DiMauro; Michio Hirano
Journal:  Nat Rev Genet       Date:  2012-12       Impact factor: 53.242

8.  Systematic analysis of the twin cx(9)c protein family.

Authors:  Sebastian Longen; Melanie Bien; Karl Bihlmaier; Christine Kloeppel; Frank Kauff; Miriam Hammermeister; Benedikt Westermann; Johannes M Herrmann; Jan Riemer
Journal:  J Mol Biol       Date:  2009-08-21       Impact factor: 5.469

9.  Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.

Authors:  Carlo Rinaldi; Christopher Grunseich; Irina F Sevrioukova; Alice Schindler; Iren Horkayne-Szakaly; Costanza Lamperti; Guida Landouré; Marina L Kennerson; Barrington G Burnett; Carsten Bönnemann; Leslie G Biesecker; Daniele Ghezzi; Massimo Zeviani; Kenneth H Fischbeck
Journal:  Am J Hum Genet       Date:  2012-12-07       Impact factor: 11.025

10.  A mitochondrial protein compendium elucidates complex I disease biology.

Authors:  David J Pagliarini; Sarah E Calvo; Betty Chang; Sunil A Sheth; Scott B Vafai; Shao-En Ong; Geoffrey A Walford; Canny Sugiana; Avihu Boneh; William K Chen; David E Hill; Marc Vidal; James G Evans; David R Thorburn; Steven A Carr; Vamsi K Mootha
Journal:  Cell       Date:  2008-07-11       Impact factor: 41.582
  10 in total
  7 in total

1.  C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.

Authors:  Tao Wang; Honghe Liu; Kie Itoh; Sungtaek Oh; Liang Zhao; Daisuke Murata; Hiromi Sesaki; Thomas Hartung; Chan Hyun Na; Jiou Wang
Journal:  Cell Metab       Date:  2021-02-04       Impact factor: 27.287

2.  The emerging picture of the mitochondrial protein import complexes of Amoebozoa supergroup.

Authors:  Małgorzata Wojtkowska; Dorota Buczek; Yutaka Suzuki; Victoria Shabardina; Wojciech Makałowski; Hanna Kmita
Journal:  BMC Genomics       Date:  2017-12-29       Impact factor: 3.969

3.  CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

Authors:  Luke W Thomas; Jenna M Stephen; Cinzia Esposito; Simon Hoer; Robin Antrobus; Afshan Ahmed; Hasan Al-Habib; Margaret Ashcroft
Journal:  Cancer Metab       Date:  2019-03-06

4.  Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Authors:  Karthik Mohanraj; Michal Wasilewski; Cristiane Benincá; Dominik Cysewski; Jaroslaw Poznanski; Paulina Sakowska; Zaneta Bugajska; Markus Deckers; Sven Dennerlein; Erika Fernandez-Vizarra; Peter Rehling; Michal Dadlez; Massimo Zeviani; Agnieszka Chacinska
Journal:  EMBO Mol Med       Date:  2019-05       Impact factor: 12.137

5.  CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism.

Authors:  Luke W Thomas; Cinzia Esposito; Jenna M Stephen; Ana S H Costa; Christian Frezza; Thomas S Blacker; Gyorgy Szabadkai; Margaret Ashcroft
Journal:  Cancer Metab       Date:  2019-07-16

Review 6.  Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging.

Authors:  Eirini Lionaki; Ilias Gkikas; Nektarios Tavernarakis
Journal:  Front Genet       Date:  2016-09-16       Impact factor: 4.599

7.  An antibody toolbox to track complex I assembly defines AIF's mitochondrial function.

Authors:  Anjaneyulu Murari; Shauna-Kay Rhooms; Naga Sri Goparaju; Maximino Villanueva; Edward Owusu-Ansah
Journal:  J Cell Biol       Date:  2020-10-05       Impact factor: 10.539
  7 in total

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