Literature DB >> 27308589

ATM: An unexpected tumor-promoting factor in HER2-expressing tumors.

Venturina Stagni1, Veronica Oropallo2, Daniela Barilà2.   

Abstract

ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.

Entities:  

Keywords:  ATM kinase; HER2 receptor tyrosine kinase; HSP90; breast cancer; tumor suppressor genes and oncogenes

Year:  2015        PMID： 27308589      PMCID： PMC4905372          DOI： 10.1080/23723556.2015.1054551

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.

Authors:  H Korkaya; A Paulson; F Iovino; M S Wicha
Journal:  Oncogene       Date:  2008-06-30       Impact factor: 9.867

Review 2.  Mechanisms of ATM Activation.

Authors:  Tanya T Paull
Journal:  Annu Rev Biochem       Date:  2015-01-12       Impact factor: 23.643

Review 3.  The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.

Authors:  Yosef Shiloh; Yael Ziv
Journal:  Nat Rev Mol Cell Biol       Date:  2013-03-13       Impact factor: 94.444

4.  Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

Authors:  Patricia A Possik; Judith Müller; Carmen Gerlach; Juliana C N Kenski; Xinyao Huang; Aida Shahrabi; Oscar Krijgsman; Ji-Ying Song; Marjon A Smit; Bram Gerritsen; Cor Lieftink; Kristel Kemper; Magali Michaut; Roderick L Beijersbergen; Lodewyk Wessels; Ton N Schumacher; Daniel S Peeper
Journal:  Cell Rep       Date:  2014-11-06       Impact factor: 9.423

5.  Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

Authors:  Georgia Velimezi; Michalis Liontos; Konstantinos Vougas; Theodoros Roumeliotis; Jirina Bartkova; Maria Sideridou; Ayguel Dereli-Oz; Maciej Kocylowski; Ioannis S Pateras; Kostas Evangelou; Athanassios Kotsinas; Ines Orsolic; Sladana Bursac; Maja Cokaric-Brdovcak; Vassilis Zoumpourlis; Dimitris Kletsas; George Papafotiou; Apostolos Klinakis; Sinisa Volarevic; Wei Gu; Jiri Bartek; Thanos D Halazonetis; Vassilis G Gorgoulis
Journal:  Nat Cell Biol       Date:  2013-07-14       Impact factor: 28.824

Review 6.  The DNA damage response: implications for tumor responses to radiation and chemotherapy.

Authors:  Michael Goldstein; Michael B Kastan
Journal:  Annu Rev Med       Date:  2014-11-24       Impact factor: 13.739

7.  ATM kinase sustains HER2 tumorigenicity in breast cancer.

Authors:  Venturina Stagni; Isabella Manni; Veronica Oropallo; Marcella Mottolese; Anna Di Benedetto; Giulia Piaggio; Rita Falcioni; Danilo Giaccari; Selene Di Carlo; Francesca Sperati; Maria Teresa Cencioni; Daniela Barilà
Journal:  Nat Commun       Date:  2015-04-16       Impact factor: 14.919

Review 8.  DNA damage signalling guards against activated oncogenes and tumour progression.

Authors:  J Bartek; J Bartkova; J Lukas
Journal:  Oncogene       Date:  2007-12-10       Impact factor: 9.867

9.  ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

Authors:  Shuhei Matsuoka; Bryan A Ballif; Agata Smogorzewska; E Robert McDonald; Kristen E Hurov; Ji Luo; Corey E Bakalarski; Zhenming Zhao; Nicole Solimini; Yaniv Lerenthal; Yosef Shiloh; Steven P Gygi; Stephen J Elledge
Journal:  Science       Date:  2007-05-25       Impact factor: 47.728

Review 10.  Tug of war between survival and death: exploring ATM function in cancer.

Authors:  Venturina Stagni; Veronica Oropallo; Giulia Fianco; Martina Antonelli; Irene Cinà; Daniela Barilà
Journal:  Int J Mol Sci       Date:  2014-03-27       Impact factor: 5.923
  10 in total
  2 in total

1.  Interaction between HER2 and ATM predicts poor survival in bladder cancer patients.

Authors:  Nada Albarakati; Alaa Al-Shareeda; Majed Ramadan; Batla Al-Sowayan; Ola Negm; Taoufik Nedjadi
Journal:  J Cell Mol Med       Date:  2022-09-03       Impact factor: 5.295

Review 2.  Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra.

Authors:  Venturina Stagni; Claudia Cirotti; Daniela Barilà
Journal:  Front Oncol       Date:  2018-03-16       Impact factor: 6.244
  2 in total

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