Literature DB >> 27308586

Genome surveillance in pluripotent stem cells: Low apoptosis threshold and efficient antioxidant defense.

Benjamin Dannenmann1, Simon Lehle1, Frank Essmann1, Klaus Schulze-Osthoff2.   

Abstract

Pluripotent stem cells must be endowed with efficient genome surveillance. Here we describe the multiple mechanisms that ensure their genome integrity, including high susceptibility to apoptosis and efficient prevention of DNA lesions. In induced pluripotent stem cells, apoptosis hypersensitivity is mediated by increased expression of proapoptotic BCL-2 protein, whereas DNA damage is prevented by the upregulation of several antioxidant enzymes. Antioxidants might be therefore employed for safer stem cell therapies.

Entities:  

Keywords:  Antioxidant; Bcl-2; DNA damage; LORD-Q; apoptosis; genome surveillance; glutathione; oxidative stress; pluripotent stem cell

Year:  2015        PMID： 27308586      PMCID： PMC4905369          DOI： 10.1080/23723556.2015.1052183

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.

Authors:  Alessandro Prigione; Beatrix Fauler; Rudi Lurz; Hans Lehrach; James Adjaye
Journal:  Stem Cells       Date:  2010-04       Impact factor: 6.277

Review 2.  The tumorigenicity of human embryonic and induced pluripotent stem cells.

Authors:  Uri Ben-David; Nissim Benvenisty
Journal:  Nat Rev Cancer       Date:  2011-03-10       Impact factor: 60.716

Review 3.  Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis.

Authors:  Regina Brigelius-Flohé; Anna Patricia Kipp
Journal:  Ann N Y Acad Sci       Date:  2012-07       Impact factor: 5.691

4.  Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

Authors:  Lyle Armstrong; Katarzyna Tilgner; Gabriele Saretzki; Stuart P Atkinson; Miodrag Stojkovic; Ruben Moreno; Stefan Przyborski; Majlinda Lako
Journal:  Stem Cells       Date:  2010-04       Impact factor: 6.277

5.  Stem cells: balancing resistance and sensitivity to DNA damage.

Authors:  Julia C Liu; Paul H Lerou; Galit Lahav
Journal:  Trends Cell Biol       Date:  2014-04-07       Impact factor: 20.808

6.  Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.

Authors:  Jiwon Jang; Yidi Wang; Hyung-Seok Kim; Matthew A Lalli; Kenneth S Kosik
Journal:  Stem Cells       Date:  2014-10       Impact factor: 6.277

7.  Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis.

Authors:  Raluca Dumitru; Vivian Gama; B Matthew Fagan; Jacquelyn J Bower; Vijay Swahari; Larysa H Pevny; Mohanish Deshmukh
Journal:  Mol Cell       Date:  2012-05-03       Impact factor: 17.970

Review 8.  Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Authors:  Holly L Baines; Douglass M Turnbull; Laura C Greaves
Journal:  Aging Cell       Date:  2014-01-28       Impact factor: 9.304

9.  High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.

Authors:  Benjamin Dannenmann; Simon Lehle; Dominic G Hildebrand; Ayline Kübler; Paula Grondona; Vera Schmid; Katharina Holzer; Mirjam Fröschl; Frank Essmann; Oliver Rothfuss; Klaus Schulze-Osthoff
Journal:  Stem Cell Reports       Date:  2015-04-30       Impact factor: 7.765

10.  LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.

Authors:  Simon Lehle; Dominic G Hildebrand; Britta Merz; Peter N Malak; Michael S Becker; Peter Schmezer; Frank Essmann; Klaus Schulze-Osthoff; Oliver Rothfuss
Journal:  Nucleic Acids Res       Date:  2013-12-26       Impact factor: 16.971
  10 in total
  5 in total

Review 1.  Genomic integrity of human induced pluripotent stem cells: Reprogramming, differentiation and applications.

Authors:  Clara Steichen; Zara Hannoun; Eléanor Luce; Thierry Hauet; Anne Dubart-Kupperschmitt
Journal:  World J Stem Cells       Date:  2019-10-26       Impact factor: 5.326

Review 2.  Effects of Antioxidant Supplements on the Survival and Differentiation of Stem Cells.

Authors:  Sara Shaban; Mostafa Wanees Ahmed El-Husseny; Abdelrahman Ibrahim Abushouk; Amr Muhammad Abdo Salem; Mediana Mamdouh; Mohamed M Abdel-Daim
Journal:  Oxid Med Cell Longev       Date:  2017-07-09       Impact factor: 6.543

3.  Redox environment in stem and differentiated cells: A quantitative approach.

Authors:  O G Lyublinskaya; Ju S Ivanova; N A Pugovkina; I V Kozhukharova; Z V Kovaleva; A N Shatrova; N D Aksenov; V V Zenin; Yu A Kaulin; I A Gamaley; N N Nikolsky
Journal:  Redox Biol       Date:  2017-04-11       Impact factor: 11.799

4.  Simultaneous quantification of DNA damage and mitochondrial copy number by long-run DNA-damage quantification (LORD-Q).

Authors:  Frank Essmann; Klaus Schulze-Osthoff; Benjamin Dannenmann; Simon Lehle; Sebastian Lorscheid; Stephan M Huber
Journal:  Oncotarget       Date:  2017-08-10

5.  Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.

Authors:  Mikio Shimada; Kaima Tsukada; Nozomi Kagawa; Yoshihisa Matsumoto
Journal:  J Radiat Res       Date:  2019-11-22       Impact factor: 2.724
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.