Literature DB >> 27308579

Vascular endothelial growth factor blockade elicits a stable metabolic shift in tumor cells: therapeutic implications.

Stefano Indraccolo1.   

Abstract

The metabolism of tumors differs remarkably from that of normal tissues, but whether this is a stable feature of tumor cells is largely unknown. Recent findings by independent teams indicate that antiangiogenic drugs cause a metabolic shift in tumor cells that is associated with increased malignancy. These results suggest therapy-driven evolutionary dynamics of tumor metabolism that could be therapeutically targeted.

Entities:  

Keywords:  VEGF; antiangiogenic therapy; cancer; glycolysis; metabolism

Year:  2015        PMID： 27308579      PMCID： PMC4905516          DOI： 10.1080/23723556.2015.1008307

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells.

Authors:  Matteo Curtarello; Elisabetta Zulato; Giorgia Nardo; Silvia Valtorta; Giulia Guzzo; Elisabetta Rossi; Giovanni Esposito; Aichi Msaki; Anna Pastò; Andrea Rasola; Luca Persano; Francesco Ciccarese; Roberta Bertorelle; Sergio Todde; Mario Plebani; Henrike Schroer; Stefan Walenta; Wolfgang Mueller-Klieser; Alberto Amadori; Rosa Maria Moresco; Stefano Indraccolo
Journal:  Cancer Res       Date:  2014-11-07       Impact factor: 12.701

Review 2.  Links between metabolism and cancer.

Authors:  Chi V Dang
Journal:  Genes Dev       Date:  2012-05-01       Impact factor: 11.361

3.  Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.

Authors:  Giorgia Nardo; Elena Favaro; Matteo Curtarello; Lidia Moserle; Elisabetta Zulato; Luca Persano; Elisabetta Rossi; Giovanni Esposito; Marika Crescenzi; Oriol Casanovas; Ulrike Sattler; Wolfgang Mueller-Klieser; Barbara Biesalski; Oliver Thews; Rossella Canese; Egidio Iorio; Paola Zanovello; Alberto Amadori; Stefano Indraccolo
Journal:  Cancer Res       Date:  2011-05-05       Impact factor: 12.701

4.  Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.

Authors:  Olivier Keunen; Mikael Johansson; Anaïs Oudin; Morgane Sanzey; Siti A Abdul Rahim; Fred Fack; Frits Thorsen; Torfinn Taxt; Michal Bartos; Radovan Jirik; Hrvoje Miletic; Jian Wang; Daniel Stieber; Linda Stuhr; Ingrid Moen; Cecilie Brekke Rygh; Rolf Bjerkvig; Simone P Niclou
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-14       Impact factor: 11.205

5.  Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

Authors:  Karim Bensaad; Elena Favaro; Caroline A Lewis; Barrie Peck; Simon Lord; Jennifer M Collins; Katherine E Pinnick; Simon Wigfield; Francesca M Buffa; Ji-Liang Li; Qifeng Zhang; Michael J O Wakelam; Fredrik Karpe; Almut Schulze; Adrian L Harris
Journal:  Cell Rep       Date:  2014-09-25       Impact factor: 9.423

Review 6.  Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.

Authors:  Ethan B Butler; Yuhua Zhao; Cristina Muñoz-Pinedo; Jianrong Lu; Ming Tan
Journal:  Cancer Res       Date:  2013-04-22       Impact factor: 12.701

7.  Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.

Authors:  Nor Eddine Sounni; Jonathan Cimino; Silvia Blacher; Irina Primac; Alice Truong; Gabriel Mazzucchelli; Alexandra Paye; David Calligaris; Delphine Debois; Pascal De Tullio; Bernard Mari; Edwin De Pauw; Agnes Noel
Journal:  Cell Metab       Date:  2014-07-10       Impact factor: 27.287

8.  Regulation of autophagy by cytosolic acetyl-coenzyme A.

Authors:  Guillermo Mariño; Federico Pietrocola; Tobias Eisenberg; Yongli Kong; Shoaib Ahmad Malik; Aleksandra Andryushkova; Sabrina Schroeder; Tobias Pendl; Alexandra Harger; Mireia Niso-Santano; Naoufal Zamzami; Marie Scoazec; Silvère Durand; David P Enot; Álvaro F Fernández; Isabelle Martins; Oliver Kepp; Laura Senovilla; Chantal Bauvy; Eugenia Morselli; Erika Vacchelli; Martin Bennetzen; Christoph Magnes; Frank Sinner; Thomas Pieber; Carlos López-Otín; Maria Chiara Maiuri; Patrice Codogno; Jens S Andersen; Joseph A Hill; Frank Madeo; Guido Kroemer
Journal:  Mol Cell       Date:  2014-02-20       Impact factor: 17.970

9.  Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.

Authors:  Fred Fack; Heidi Espedal; Olivier Keunen; Anna Golebiewska; Nina Obad; Patrick N Harter; Michel Mittelbronn; Oliver Bähr; Astrid Weyerbrock; Linda Stuhr; Hrvoje Miletic; Per Ø Sakariassen; Daniel Stieber; Cecilie B Rygh; Morten Lund-Johansen; Liang Zheng; Eyal Gottlieb; Simone P Niclou; Rolf Bjerkvig
Journal:  Acta Neuropathol       Date:  2014-10-17       Impact factor: 17.088

10.  Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma.

Authors:  C D Hudson; T Hagemann; S J Mather; N Avril
Journal:  Cell Death Dis       Date:  2014-04-10       Impact factor: 8.469
  10 in total
  1 in total

1.  Reprogramming Tumor-Immune Cell Interface in Solid and Hematological Malignancies to Enhance Response to Therapy.

Authors:  Maria Teresa Di Martino; Francesca Zazzeroni; Massimo Donadelli; Claudia Chiodoni; Michele Caraglia; Katia Scotlandi; Stefania Meschini; Carlo Leonetti
Journal:  J Exp Clin Cancer Res       Date:  2018-03-05
  1 in total

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