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Literature DB >> 27308578

SLX4 gains weight with SUMO in genome maintenance.

Jean-Hugues Guervilly¹, Pierre-Henri L Gaillard¹.

Abstract

Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles' heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair protein SLX4 that influence the outcome of replication stress open new avenues for investigating the roles played by SLX4 in tumorigenesis.

Entities: Disease Gene

Keywords: BTB domain; Chromosome stability; DNA damage response; E3 SUMO ligase; Fanconi anemia; SLX4; SUMO; SUMO Interaction Motifs; XPF-ERCC1; oncogenesis; replication stress; signal transduction; structure-specific endonuclease; tumor suppressor

Year: 2015 PMID： 27308578 PMCID： PMC4905331 DOI： 10.1080/23723556.2015.1008297

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.

Authors: Jean-Hugues Guervilly; Arato Takedachi; Valeria Naim; Sarah Scaglione; Charly Chawhan; Yoann Lovera; Emmanuelle Despras; Isao Kuraoka; Patricia Kannouche; Filippo Rosselli; Pierre-Henri L Gaillard
Journal: Mol Cell Date: 2014-12-18 Impact factor: 17.970

2. ATR phosphorylates SMARCAL1 to prevent replication fork collapse.

Authors: Frank B Couch; Carol E Bansbach; Robert Driscoll; Jessica W Luzwick; Gloria G Glick; Rémy Bétous; Clinton M Carroll; Sung Yun Jung; Jun Qin; Karlene A Cimprich; David Cortez
Journal: Genes Dev Date: 2013-07-15 Impact factor: 11.361

3. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

Authors: Nadine Laguette; Christelle Brégnard; Pauline Hue; Jihane Basbous; Ahmad Yatim; Marion Larroque; Frank Kirchhoff; Angelos Constantinou; Bijan Sobhian; Monsef Benkirane
Journal: Cell Date: 2014-01-09 Impact factor: 41.582

4. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.

Authors: Jian Ouyang; Elizabeth Garner; Alexander Hallet; Hai Dang Nguyen; Kimberly A Rickman; Grace Gill; Agata Smogorzewska; Lee Zou
Journal: Mol Cell Date: 2014-12-18 Impact factor: 17.970

1 in total

Review 1. Rescue from replication stress during mitosis.

Authors: Michalis Fragkos; Valeria Naim
Journal: Cell Cycle Date: 2017-02-06 Impact factor: 4.534

1 in total

SLX4 gains weight with SUMO in genome maintenance.

1. The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.

2. ATR phosphorylates SMARCAL1 to prevent replication fork collapse.

3. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

4. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.

5. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

6. DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.

7. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.

8. RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.

9. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.

Review 10. Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.

Review 1. Rescue from replication stress during mitosis.