Literature DB >> 27308574

High hyperdiploid childhood acute lymphoblastic leukemia: Chromosomal gains as the main driver event.

Kajsa Paulsson1.   

Abstract

High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.

Entities:  

Keywords:  Acute lymphoblastic leukemia; aneuploidy; chromosome; hyperdiploidy; mutation

Year:  2015        PMID： 27308574      PMCID： PMC4845247          DOI： 10.1080/23723556.2015.1064555

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14.

Authors:  T Szczepański; M J Willemse; E R van Wering; J F van Weerden; W A Kamps; J J van Dongen
Journal:  Leukemia       Date:  2001-09       Impact factor: 11.528

2.  The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  Kajsa Paulsson; Henrik Lilljebjörn; Andrea Biloglav; Linda Olsson; Marianne Rissler; Anders Castor; Gisela Barbany; Linda Fogelstrand; Ann Nordgren; Helene Sjögren; Thoas Fioretos; Bertil Johansson
Journal:  Nat Genet       Date:  2015-05-11       Impact factor: 38.330

3.  Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.

Authors:  Anna Andersson; Tor Olofsson; David Lindgren; Björn Nilsson; Cecilia Ritz; Patrik Edén; Carin Lassen; Johan Råde; Magnus Fontes; Helena Mörse; Jesper Heldrup; Mikael Behrendtz; Felix Mitelman; Mattias Höglund; Bertil Johansson; Thoas Fioretos
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-14       Impact factor: 11.205

4.  Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  Alicja M Gruszka-Westwood; Sharon W Horsley; Angel Martinez-Ramirez; Christine J Harrison; Helena Kempski; Anthony V Moorman; Fiona M Ross; Michael Griffiths; Mel F Greaves; Lyndal Kearney
Journal:  Genes Chromosomes Cancer       Date:  2004-11       Impact factor: 5.006

5.  Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  Kajsa Paulsson; Andrea Horvat; Bodil Strömbeck; Fredrik Nilsson; Jesper Heldrup; Mikael Behrendtz; Erik Forestier; Anna Andersson; Thoas Fioretos; Bertil Johansson
Journal:  Genes Chromosomes Cancer       Date:  2008-01       Impact factor: 5.006

6.  Evolutionary trajectories of hyperdiploid ALL in monozygotic twins.

Authors:  C M Bateman; D Alpar; A M Ford; S M Colman; D Wren; M Morgan; L Kearney; M Greaves
Journal:  Leukemia       Date:  2014-06-04       Impact factor: 11.528

Review 7.  High hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  Kajsa Paulsson; Bertil Johansson
Journal:  Genes Chromosomes Cancer       Date:  2009-08       Impact factor: 5.006

8.  Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood.

Authors:  Ana Teresa Maia; Roxane Tussiwand; Giovanni Cazzaniga; Paolo Rebulla; Susan Colman; Andrea Biondi; Mel Greaves
Journal:  Genes Chromosomes Cancer       Date:  2004-05       Impact factor: 5.006

9.  CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia.

Authors:  A Inthal; P Zeitlhofer; M Zeginigg; M Morak; R Grausenburger; E Fronkova; B Fahrner; G Mann; O A Haas; R Panzer-Grümayer
Journal:  Leukemia       Date:  2012-03-05       Impact factor: 11.528

10.  KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia.

Authors:  K Malinowska-Ozdowy; C Frech; A Schönegger; C Eckert; G Cazzaniga; M Stanulla; U zur Stadt; A Mecklenbräuker; M Schuster; D Kneidinger; A von Stackelberg; F Locatelli; M Schrappe; M A Horstmann; A Attarbaschi; C Bock; G Mann; O A Haas; R Panzer-Grümayer
Journal:  Leukemia       Date:  2015-04-28       Impact factor: 11.528
  10 in total
  4 in total

Review 1.  Is There Etiologic Heterogeneity between Subtypes of Childhood Acute Lymphoblastic Leukemia? A Review of Variation in Risk by Subtype.

Authors:  Lindsay A Williams; Jun J Yang; Betsy A Hirsch; Erin L Marcotte; Logan G Spector
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2019-02-15       Impact factor: 4.254

Review 2.  Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome.

Authors:  Anouchka P Laurent; Rishi S Kotecha; Sébastien Malinge
Journal:  Leukemia       Date:  2020-05-20       Impact factor: 11.528

3.  Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT/non-SHH medulloblastoma: a retrospective, molecular analysis of the HIT-SIOP PNET 4 trial.

Authors:  Tobias Goschzik; Edward C Schwalbe; Debbie Hicks; Amanda Smith; Anja Zur Muehlen; Dominique Figarella-Branger; François Doz; Stefan Rutkowski; Birgitta Lannering; Torsten Pietsch; Steven C Clifford
Journal:  Lancet Oncol       Date:  2018-11-01       Impact factor: 41.316

Review 4.  Near-Haploidy and Low-Hypodiploidy in B-Cell Acute Lymphoblastic Leukemia: When Less Is Too Much.

Authors:  Oscar Molina; Alex Bataller; Namitha Thampi; Jordi Ribera; Isabel Granada; Pablo Velasco; José Luis Fuster; Pablo Menéndez
Journal:  Cancers (Basel)       Date:  2021-12-22       Impact factor: 6.639
  4 in total

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