Literature DB >> 27308567

When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers.

Nuala McCabe1, Steven M Walker1, Richard D Kennedy1.   

Abstract

Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN-associated cancers.

Entities:  

Keywords:  ATM; DNA damage; DSB; PTEN; ROS

Year:  2015        PMID： 27308567      PMCID： PMC4845205          DOI： 10.1080/23723556.2015.1053595

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Targeting the DNA damage response in oncology: past, present and future perspectives.

Authors:  Bristi Basu; Timothy A Yap; L Rhoda Molife; Johann S de Bono
Journal:  Curr Opin Oncol       Date:  2012-05       Impact factor: 3.645

Review 2.  The concept of synthetic lethality in the context of anticancer therapy.

Authors:  William G Kaelin
Journal:  Nat Rev Cancer       Date:  2005-09       Impact factor: 60.716

Review 3.  The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.

Authors:  Yosef Shiloh; Yael Ziv
Journal:  Nat Rev Mol Cell Biol       Date:  2013-03-13       Impact factor: 94.444

4.  Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.

Authors:  Richard D Kennedy; Clark C Chen; Patricia Stuckert; Elyse M Archila; Michelle A De la Vega; Lisa A Moreau; Akiko Shimamura; Alan D D'Andrea
Journal:  J Clin Invest       Date:  2007-04-12       Impact factor: 14.808

5.  ATM activation by oxidative stress.

Authors:  Zhi Guo; Sergei Kozlov; Martin F Lavin; Maria D Person; Tanya T Paull
Journal:  Science       Date:  2010-10-22       Impact factor: 47.728

6.  Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.

Authors:  Jirina Bartkova; Nousin Rezaei; Michalis Liontos; Panagiotis Karakaidos; Dimitris Kletsas; Natalia Issaeva; Leandros-Vassilios F Vassiliou; Evangelos Kolettas; Katerina Niforou; Vassilis C Zoumpourlis; Munenori Takaoka; Hiroshi Nakagawa; Frederic Tort; Kasper Fugger; Fredrik Johansson; Maxwell Sehested; Claus L Andersen; Lars Dyrskjot; Torben Ørntoft; Jiri Lukas; Christos Kittas; Thomas Helleday; Thanos D Halazonetis; Jiri Bartek; Vassilis G Gorgoulis
Journal:  Nature       Date:  2006-11-30       Impact factor: 49.962

Review 7.  Modulation of oxidative stress as an anticancer strategy.

Authors:  Chiara Gorrini; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Drug Discov       Date:  2013-12       Impact factor: 84.694

8.  Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.

Authors:  Nuala McCabe; Conor Hanna; Steven M Walker; David Gonda; Jie Li; Katarina Wikstrom; Kienan I Savage; Karl T Butterworth; Clark Chen; D Paul Harkin; Kevin M Prise; Richard D Kennedy
Journal:  Cancer Res       Date:  2015-04-13       Impact factor: 12.701

9.  Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.

Authors:  Ross Carruthers; Shafiq U Ahmed; Karen Strathdee; Natividad Gomez-Roman; Evelyn Amoah-Buahin; Colin Watts; Anthony J Chalmers
Journal:  Mol Oncol       Date:  2014-08-24       Impact factor: 6.603

Review 10.  PTEN: Multiple Functions in Human Malignant Tumors.

Authors:  Michele Milella; Italia Falcone; Fabiana Conciatori; Ursula Cesta Incani; Anais Del Curatolo; Nicola Inzerilli; Carmen M A Nuzzo; Vanja Vaccaro; Sabrina Vari; Francesco Cognetti; Ludovica Ciuffreda
Journal:  Front Oncol       Date:  2015-02-16       Impact factor: 6.244
  10 in total
  4 in total

1.  Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression.

Authors:  Li-Mei Chen; Po-Yen Liu; Yen-An Chen; Hong-Yu Tseng; Pei-Chun Shen; Pai-An Hwang; Hsin-Ling Hsu
Journal:  Sci Rep       Date:  2017-09-19       Impact factor: 4.379

Review 2.  Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.

Authors:  Alessandra Leone; Maria Serena Roca; Chiara Ciardiello; Susan Costantini; Alfredo Budillon
Journal:  Oxid Med Cell Longev       Date:  2017-07-09       Impact factor: 6.543

3.  Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3K/Akt/PTEN Signaling Pathway in Liver Cancer.

Authors:  Nan-Nan Li; Xian-Sheng Meng; Wen-Xiao Men; Yong-Rui Bao; Shuai Wang
Journal:  Evid Based Complement Alternat Med       Date:  2018-02-15       Impact factor: 2.629

Review 4.  Targeting DNA Damage Response in Prostate and Breast Cancer.

Authors:  Antje M Wengner; Arne Scholz; Bernard Haendler
Journal:  Int J Mol Sci       Date:  2020-11-04       Impact factor: 5.923
  4 in total

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