Literature DB >> 27308559

AATF: A new actor in the complex world of mTOR.

Maurizio Fanciulli1.   

Abstract

Reflecting the pivotal role of mammalian target of rapamycin (mTOR) in the cell, a number of pathways, several of which exhibit changes in expression or activity in different cancers, tightly control its activation. We have recently demonstrated that antiapoptotic transcription factor (AATF) regulates mTOR in response to several kinds of stress.

Entities:  

Keywords:  AATF; autophagy; cellular stress; mTOR

Year:  2015        PMID： 27308559      PMCID： PMC4845199          DOI： 10.1080/23723556.2015.1040946

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

2.  DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Authors:  Timothy R Peterson; Mathieu Laplante; Carson C Thoreen; Yasemin Sancak; Seong A Kang; W Michael Kuehl; Nathanael S Gray; David M Sabatini
Journal:  Cell       Date:  2009-05-14       Impact factor: 41.582

3.  Plasma cells require autophagy for sustainable immunoglobulin production.

Authors:  Niccolò Pengo; Maria Scolari; Laura Oliva; Enrico Milan; Federica Mainoldi; Andrea Raimondi; Claudio Fagioli; Arianna Merlini; Elisabetta Mariani; Elena Pasqualetto; Ugo Orfanelli; Maurilio Ponzoni; Roberto Sitia; Stefano Casola; Simone Cenci
Journal:  Nat Immunol       Date:  2013-01-27       Impact factor: 25.606

4.  Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.

Authors:  Agata Desantis; Tiziana Bruno; Valeria Catena; Francesca De Nicola; Frauke Goeman; Simona Iezzi; Cristina Sorino; Maurilio Ponzoni; Gianluca Bossi; Vincenzo Federico; Francesca La Rosa; Maria Rosaria Ricciardi; Elena Lesma; Paolo D'Onorio De Meo; Tiziana Castrignanò; Maria Teresa Petrucci; Francesco Pisani; Marta Chesi; P Leif Bergsagel; Aristide Floridi; Giovanni Tonon; Claudio Passananti; Giovanni Blandino; Maurizio Fanciulli
Journal:  EMBO J       Date:  2015-03-14       Impact factor: 11.598

Review 5.  TOR-dependent control of autophagy: biting the hand that feeds.

Authors:  Thomas P Neufeld
Journal:  Curr Opin Cell Biol       Date:  2009-12-16       Impact factor: 8.382

6.  AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.

Authors:  Katja Höpker; Henning Hagmann; Safiya Khurshid; Shuhua Chen; Pia Hasskamp; Tamina Seeger-Nukpezah; Katharina Schilberg; Lukas Heukamp; Tobias Lamkemeyer; Martin L Sos; Roman K Thomas; Drew Lowery; Frederik Roels; Matthias Fischer; Max C Liebau; Ulrike Resch; Tülay Kisner; Fabian Röther; Malte P Bartram; Roman Ulrich Müller; Francesca Fabretti; Peter Kurschat; Björn Schumacher; Matthias Gaestel; René H Medema; Michael B Yaffe; Bernhard Schermer; H Christian Reinhardt; Thomas Benzing
Journal:  EMBO J       Date:  2012-08-21       Impact factor: 11.598

Review 7.  Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.

Authors:  Shomit Sengupta; Timothy R Peterson; David M Sabatini
Journal:  Mol Cell       Date:  2010-10-22       Impact factor: 17.970

Review 8.  Autophagy and the integrated stress response.

Authors:  Guido Kroemer; Guillermo Mariño; Beth Levine
Journal:  Mol Cell       Date:  2010-10-22       Impact factor: 17.970

9.  Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.

Authors:  Tiziana Bruno; Francesca De Nicola; Simona Iezzi; Daniele Lecis; Carmen D'Angelo; Monica Di Padova; Nicoletta Corbi; Leopoldo Dimiziani; Laura Zannini; Christian Jekimovs; Marco Scarsella; Alessandro Porrello; Alberto Chersi; Marco Crescenzi; Carlo Leonetti; Kum Kum Khanna; Silvia Soddu; Aristide Floridi; Claudio Passananti; Domenico Delia; Maurizio Fanciulli
Journal:  Cancer Cell       Date:  2006-12       Impact factor: 31.743

Review 10.  Discovering Che-1/AATF: a new attractive target for cancer therapy.

Authors:  Simona Iezzi; Maurizio Fanciulli
Journal:  Front Genet       Date:  2015-04-10       Impact factor: 4.599
  10 in total

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