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Literature DB >> 27308558

Paracrine WNT5A signaling in healthy and neoplastic mammary tissue.

David Kusner¹, Nicholas Borcherding², Weizhou Zhang³.

Abstract

Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

Entities: Disease Gene

Keywords: Breast cancer; Noncanonical WNT; WNT5A signaling; mammary development

Year: 2015 PMID： 27308558 PMCID： PMC4845198 DOI： 10.1080/23723556.2015.1040145

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

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References

10 in total

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Journal: Nature Date: 2006-01-05 Impact factor: 49.962

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Authors: Kevin Roarty; Sarah E Baxley; Michael R Crowley; Andra R Frost; Rosa Serra
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10 in total

Paracrine WNT5A signaling in healthy and neoplastic mammary tissue.

1. Generation of a functional mammary gland from a single stem cell.

2. Purification and unique properties of mammary epithelial stem cells.

3. Progesterone induces adult mammary stem cell expansion.

4. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.

5. Control of mammary stem cell function by steroid hormone signalling.

6. Reversible inhibition of mammary gland growth by transforming growth factor-beta.

7. Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk.

8. Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells.

9. Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth.

10. Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype.