Literature DB >> 27308552

A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.

Geou-Yarh Liou1, Peter Storz1, Michael Leitges2.   

Abstract

Pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-to-ductal metaplasia (ADM). ADM is initiated in response to growth factors, inflammation, and oncogene activation and leads to a de-differentiated, duct-like phenotype. Our recent publication demonstrated a transforming growth factor α-Kras(G12D)-protein kinase D1-Notch1 signaling axis driving the induction of ADM and further progression to pancreatic intraepithelial neoplasia. This suggests that protein kinase D1 might be an early marker for tumor development and a potential target for drug development.

Entities:  

Keywords:  Acinar-to-ductal metaplasia; mechanisms of oncogenesis and tumor progression; mouse model; oncogenic Kras; pancreatic cancer; protein kinase D1

Year:  2015        PMID： 27308552      PMCID： PMC4845192          DOI： 10.1080/23723556.2015.1035477

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.

Authors:  Pawel K Mazur; Henrik Einwächter; Marcel Lee; Bence Sipos; Hassan Nakhai; Roland Rad; Ursula Zimber-Strobl; Lothar J Strobl; Freddy Radtke; Günter Klöppel; Roland M Schmid; Jens T Siveke
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

2.  Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.

Authors:  Eleni Maniati; Maud Bossard; Natalie Cook; Juliana B Candido; Nia Emami-Shahri; Sergei A Nedospasov; Frances R Balkwill; David A Tuveson; Thorsten Hagemann
Journal:  J Clin Invest       Date:  2011-11-07       Impact factor: 14.808

3.  Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.

Authors:  Meredith A Collins; Filip Bednar; Yaqing Zhang; Jean-Christophe Brisset; Stefanie Galbán; Craig J Galbán; Sabita Rakshit; Karen S Flannagan; N Volkan Adsay; Marina Pasca di Magliano
Journal:  J Clin Invest       Date:  2012-01-09       Impact factor: 14.808

4.  Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells.

Authors:  Nobuo Ochi; Suebpong Tanasanvimon; Yoichi Matsuo; Zhimin Tong; Bokyung Sung; Bharat B Aggarwal; James Sinnett-Smith; Enrique Rozengurt; Sushovan Guha
Journal:  J Cell Physiol       Date:  2011-04       Impact factor: 6.384

5.  Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells.

Authors:  Bin Bao; Zhiwei Wang; Shadan Ali; Dejuan Kong; Yiwei Li; Aamir Ahmad; Sanjeev Banerjee; Asfar S Azmi; Lucio Miele; Fazlul H Sarkar
Journal:  Cancer Lett       Date:  2011-04-03       Impact factor: 8.679

6.  Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer.

Authors:  Muxing Kang; Biao Jiang; Bin Xu; Wenjie Lu; Qingqu Guo; Qiuping Xie; Bo Zhang; Xin Dong; Daniel Chen; Yulian Wu
Journal:  Cancer Lett       Date:  2012-11-27       Impact factor: 8.679

Review 7.  Pancreatic cancer stem cells and EMT in drug resistance and metastasis.

Authors:  F H Sarkar; Y Li; Z Wang; D Kong
Journal:  Minerva Chir       Date:  2009-10       Impact factor: 1.000

8.  Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.

Authors:  Jean-Paul De La O; Lyska L Emerson; Jessica L Goodman; Scott C Froebe; Benjamin E Illum; Andrew B Curtis; L Charles Murtaugh
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-21       Impact factor: 11.205

9.  Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.

Authors:  Christoph Wille; Conny Köhler; Milena Armacki; Arsia Jamali; Ulrike Gössele; Klaus Pfizenmaier; Thomas Seufferlein; Tim Eiseler
Journal:  Mol Biol Cell       Date:  2013-12-11       Impact factor: 4.138

10.  Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Authors:  Geou-Yarh Liou; Heike Döppler; Ursula B Braun; Richard Panayiotou; Michele Scotti Buzhardt; Derek C Radisky; Howard C Crawford; Alan P Fields; Nicole R Murray; Q Jane Wang; Michael Leitges; Peter Storz
Journal:  Nat Commun       Date:  2015-02-20       Impact factor: 14.919
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.