Literature DB >> 27308551

Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimmers.

Sanjay Premi1, Douglas E Brash1.   

Abstract

Ultraviolet radiation (UVR) instantaneously generates cyclobutane pyrimidine dimers (CPDs). Paradoxically, we recently observed that UV enables the protective pigment melanin to create CPDs in the dark long after the exposure ends. UV-induced reactive oxygen species (ROS) oxidize melanin to create melanin carbonyls in a high-energy quantum state. These energetic melanin carbonyls transfer their energy to DNA in the dark, creating CPDs in the absence of UVR.

Entities:  

Keywords:  DNA damage; melanin; melanoma; models of oncogenesis; photobiology; ultraviolet radiation

Year:  2015        PMID： 27308551      PMCID： PMC4845191          DOI： 10.1080/23723556.2015.1033588

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  Douglas E Brash
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Journal:  Biochim Biophys Acta       Date:  2009-04-15

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Journal:  Chem Res Toxicol       Date:  2007-07-13       Impact factor: 3.739

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Journal:  J Cell Sci       Date:  1994-09       Impact factor: 5.285
  10 in total
  3 in total

1.  Genomic basis for RNA alterations in cancer.

Authors:  Claudia Calabrese; Natalie R Davidson; Deniz Demircioğlu; Nuno A Fonseca; Yao He; André Kahles; Kjong-Van Lehmann; Fenglin Liu; Yuichi Shiraishi; Cameron M Soulette; Lara Urban; Liliana Greger; Siliang Li; Dongbing Liu; Marc D Perry; Qian Xiang; Fan Zhang; Junjun Zhang; Peter Bailey; Serap Erkek; Katherine A Hoadley; Yong Hou; Matthew R Huska; Helena Kilpinen; Jan O Korbel; Maximillian G Marin; Julia Markowski; Tannistha Nandi; Qiang Pan-Hammarström; Chandra Sekhar Pedamallu; Reiner Siebert; Stefan G Stark; Hong Su; Patrick Tan; Sebastian M Waszak; Christina Yung; Shida Zhu; Philip Awadalla; Chad J Creighton; Matthew Meyerson; B F Francis Ouellette; Kui Wu; Huanming Yang; Alvis Brazma; Angela N Brooks; Jonathan Göke; Gunnar Rätsch; Roland F Schwarz; Oliver Stegle; Zemin Zhang
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

2.  Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway.

Authors:  Siqi Zhou; Kazuichi Sakamoto
Journal:  PLoS One       Date:  2020-12-17       Impact factor: 3.240

Review 3.  UVA Radiation, DNA Damage, and Melanoma.

Authors:  Seung-Gi Jin; Francisco Padron; Gerd P Pfeifer
Journal:  ACS Omega       Date:  2022-09-08
  3 in total

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