Literature DB >> 27308550

Δ113p53/Δ133p53 converts P53 from a repressor to a promoter of DNA double-stand break repair.

Lu Gong1, Jun Chen1.   

Abstract

In response to DNA damage, p53 (TP53, best known as p53) is quickly activated leading to cell cycle arrest or apoptosis to ensure genomic integrity; however, this represses DNA double-strand break (DSB) repair. Our recent work revealed that Δ113p53/Δ133p53 protein is accumulated at a later stage upon DNA DSB stress to switch p53 signaling from repression to promotion of DNA DSB repair.

Entities:  

Keywords:  Cell death; HR; NHEJ; SSA; p53 isoform Δ113p53/Δ133p53; senescence

Year:  2015        PMID： 27308550      PMCID： PMC4845190          DOI： 10.1080/23723556.2015.1033587

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Genome maintenance mechanisms for preventing cancer.

Authors:  J H Hoeijmakers
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

2.  Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

Authors:  Yoav Mayshar; Uri Ben-David; Neta Lavon; Juan-Carlos Biancotti; Benjamin Yakir; Amander T Clark; Kathrin Plath; William E Lowry; Nissim Benvenisty
Journal:  Cell Stem Cell       Date:  2010-10-08       Impact factor: 24.633

3.  DNA double-strand break repair activities in mammary epithelial cells--influence of endogenous p53 variants.

Authors:  Marlen Keimling; Lisa Wiesmüller
Journal:  Carcinogenesis       Date:  2009-05-08       Impact factor: 4.944

4.  A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity.

Authors:  Rosa M Marión; Katerina Strati; Han Li; Matilde Murga; Raquel Blanco; Sagrario Ortega; Oscar Fernandez-Capetillo; Manuel Serrano; Maria A Blasco
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

5.  p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.

Authors:  Lu Gong; Hongjian Gong; Xiao Pan; Changqing Chang; Zhao Ou; Shengfan Ye; Le Yin; Lina Yang; Ting Tao; Zhenhai Zhang; Cong Liu; David P Lane; Jinrong Peng; Jun Chen
Journal:  Cell Res       Date:  2015-02-20       Impact factor: 25.617

6.  p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter.

Authors:  V Marcel; V Vijayakumar; L Fernández-Cuesta; H Hafsi; C Sagne; A Hautefeuille; M Olivier; P Hainaut
Journal:  Oncogene       Date:  2010-03-01       Impact factor: 9.867

7.  p53 Isoforms: An Intracellular Microprocessor?

Authors:  Marie P Khoury; Jean-Christophe Bourdon
Journal:  Genes Cancer       Date:  2011-04

Review 8.  The first 30 years of p53: growing ever more complex.

Authors:  Arnold J Levine; Moshe Oren
Journal:  Nat Rev Cancer       Date:  2009-10       Impact factor: 60.716

9.  p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.

Authors:  Jun Chen; Sok Meng Ng; Changqing Chang; Zhenhai Zhang; Jean-Christophe Bourdon; David P Lane; Jinrong Peng
Journal:  Genes Dev       Date:  2009-02-01       Impact factor: 11.361

10.  p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.

Authors:  Serif Senturk; Zhan Yao; Matthew Camiolo; Brendon Stiles; Trushar Rathod; Alice M Walsh; Alice Nemajerova; Matthew J Lazzara; Nasser K Altorki; Adrian Krainer; Ute M Moll; Scott W Lowe; Luca Cartegni; Raffaella Sordella
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-29       Impact factor: 11.205
  10 in total
  4 in total

1.  Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.

Authors:  Petar Stefanov Kovachev; Debapriya Banerjee; Luciana Pereira Rangel; Jonny Eriksson; Murilo M Pedrote; Mafalda Maria D C Martins-Dinis; Katarina Edwards; Yraima Cordeiro; Jerson L Silva; Suparna Sanyal
Journal:  J Biol Chem       Date:  2017-04-18       Impact factor: 5.157

Review 2.  p53 Isoforms as Cancer Biomarkers and Therapeutic Targets.

Authors:  Liuqun Zhao; Suparna Sanyal
Journal:  Cancers (Basel)       Date:  2022-06-27       Impact factor: 6.575

3.  A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation.

Authors:  Lu Gong; Xiao Pan; Chuan-Bian Lim; Anna de Polo; John B Little; Zhi-Min Yuan
Journal:  Oncogene       Date:  2018-01-26       Impact factor: 9.867

4.  Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis.

Authors:  Yang Liu; Chunyan Yang; Yong Zhao; Qiang Chi; Zhen Wang; Boshi Sun
Journal:  Aging (Albany NY)       Date:  2019-12-20       Impact factor: 5.682
  4 in total

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