Literature DB >> 27308549

LDL Receptor: An open route to feed pancreatic tumor cells.

Sophie Vasseur1, Fabienne Guillaumond1.   

Abstract

The role of altered lipid metabolism in pancreatic ductal adenocarcinoma (PDAC) is poorly appreciated. We recently identified the lipid signature of PDAC and revealed low-density lipoprotein receptor (Ldlr) as a metabolic driver of this disease. Here, we comment our findings that disruption of Ldlr leads to intratumoral cholesterol imbalance and improves chemotherapy efficiency.

Entities:  

Keywords:  Cholesterol; Ldlr; gemcitabine; mechanisms of oncogenesis and tumor progression; metabolism; novel therapeutic targets; pancreatic cancer; tumor metabolism

Year:  2015        PMID： 27308549      PMCID： PMC4845189          DOI： 10.1080/23723556.2015.1033586

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Authors:  Christina M Ferrer; Thomas P Lynch; Valerie L Sodi; John N Falcone; Luciana P Schwab; Danielle L Peacock; David J Vocadlo; Tiffany N Seagroves; Mauricio J Reginato
Journal:  Mol Cell       Date:  2014-05-22       Impact factor: 17.970

2.  Pancreatic cancer: Disrupted lipid metabolic pathways in PDAC identified.

Authors:  Claire Greenhill
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2015-02-24       Impact factor: 46.802

Review 3.  Famine versus feast: understanding the metabolism of tumors in vivo.

Authors:  Jared R Mayers; Matthew G Vander Heiden
Journal:  Trends Biochem Sci       Date:  2015-01-29       Impact factor: 13.807

Review 4.  Pancreatic adenocarcinoma.

Authors:  David P Ryan; Theodore S Hong; Nabeel Bardeesy
Journal:  N Engl J Med       Date:  2014-09-11       Impact factor: 91.245

Review 5.  Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids.

Authors:  Nousheen Zaidi; Leslie Lupien; Nancy B Kuemmerle; William B Kinlaw; Johannes V Swinnen; Karine Smans
Journal:  Prog Lipid Res       Date:  2013-08-31       Impact factor: 16.195

Review 6.  Metabolic rewiring of pancreatic ductal adenocarcinoma: New routes to follow within the maze.

Authors:  Orianne Olivares; Sophie Vasseur
Journal:  Int J Cancer       Date:  2015-03-18       Impact factor: 7.396

7.  Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma.

Authors:  Fabienne Guillaumond; Ghislain Bidaut; Mehdi Ouaissi; Stéphane Servais; Victoire Gouirand; Orianne Olivares; Sophie Lac; Laurence Borge; Julie Roques; Odile Gayet; Michelle Pinault; Cyrille Guimaraes; Jérémy Nigri; Céline Loncle; Marie-Noëlle Lavaut; Stéphane Garcia; Anne Tailleux; Bart Staels; Ezequiel Calvo; Richard Tomasini; Juan Lucio Iovanna; Sophie Vasseur
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

8.  Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.

Authors:  Fabienne Guillaumond; Julie Leca; Orianne Olivares; Marie-Noëlle Lavaut; Nicolas Vidal; Patrice Berthezène; Nelson Javier Dusetti; Céline Loncle; Ezequiel Calvo; Olivier Turrini; Juan Lucio Iovanna; Richard Tomasini; Sophie Vasseur
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-13       Impact factor: 11.205

9.  Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.

Authors:  Wen Yi; Peter M Clark; Daniel E Mason; Marie C Keenan; Collin Hill; William A Goddard; Eric C Peters; Edward M Driggers; Linda C Hsieh-Wilson
Journal:  Science       Date:  2012-08-24       Impact factor: 47.728

10.  Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis.

Authors:  Hongqiang Chen; Shiyong Qin; Minghai Wang; Tao Zhang; Shuguang Zhang
Journal:  Sci Rep       Date:  2015-02-04       Impact factor: 4.379
  10 in total
  15 in total

1.  An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma.

Authors:  Leslie E Lupien; Evan M Dunkley; Margaret J Maloy; Ian B Lehner; Maxwell G Foisey; Maddison E Ouellette; Lionel D Lewis; Darcy Bates Pooler; William B Kinlaw; Paul W Baures
Journal:  J Pharmacol Exp Ther       Date:  2019-07-12       Impact factor: 4.030

2.  Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor.

Authors:  Jia Gu; Neng Zhu; Hong-Fang Li; Tan-Jun Zhao; Chan-Juan Zhang; Duan-Fang Liao; Li Qin
Journal:  Cell Oncol (Dordr)       Date:  2022-07-22       Impact factor: 7.051

Review 3.  The Multifaceted Biology of PCSK9.

Authors:  Nabil G Seidah; Annik Prat
Journal:  Endocr Rev       Date:  2022-05-12       Impact factor: 25.261

4.  Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival.

Authors:  Steven L Gonias; Nicki Karimi-Mostowfi; Sarah S Murray; Elisabetta Mantuano; Andrew S Gilder
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240

5.  Exosomal survivin facilitates vesicle internalization.

Authors:  Amber Gonda; Janviere Kabagwira; Girish N Senthil; Heather R Ferguson Bennit; Jonathan W Neidigh; Salma Khan; Nathan R Wall
Journal:  Oncotarget       Date:  2018-10-09

Review 6.  KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism.

Authors:  Isaac James Muyinda; Jae-Gwang Park; Eun-Jung Jang; Byong-Chul Yoo
Journal:  Int J Mol Sci       Date:  2021-05-11       Impact factor: 5.923

7.  Low-dose statin treatment increases prostate cancer aggressiveness.

Authors:  Laura Camacho; Amaia Zabala-Letona; Alfredo Caro-Maldonado; Verónica Torrano; Sonia Fernández-Ruiz; Kepa Zamacola-Bascaran; Leire Arreal; Lorea Valcárcel-Jiménez; Natalia Martín-Martín; Juana M Flores; Ana R Cortazar; Patricia Zúñiga-García; Amaia Arruabarrena-Aristorena; Fabienne Guillaumond; Diana Cabrera; Juan M Falcón-Perez; Ana M Aransay; Antonio Gomez-Muñoz; Mireia Olivan; Juan Morote; Arkaitz Carracedo
Journal:  Oncotarget       Date:  2017-10-31

8.  Targeting lipid droplet lysophosphatidylcholine for cisplatin chemotherapy.

Authors:  Lumin Chen; Wen-Lung Ma; Wei-Chung Cheng; Juan-Cheng Yang; Hsiao-Ching Wang; Yu-Ting Su; Azaj Ahmad; Yao-Ching Hung; Wei-Chun Chang
Journal:  J Cell Mol Med       Date:  2020-06-16       Impact factor: 5.310

Review 9.  Fibroblasts as Modulators of Local and Systemic Cancer Metabolism.

Authors:  Hannah Sanford-Crane; Jaime Abrego; Mara H Sherman
Journal:  Cancers (Basel)       Date:  2019-05-03       Impact factor: 6.639

10.  Himalayan Nettle Girardinia diversifolia as a Candidate Ingredient for Pharmaceutical and Nutraceutical Applications-Phytochemical Analysis and In Vitro Bioassays.

Authors:  Shyam Sharan Shrestha; Stefania Sut; Irene Ferrarese; Serena Barbon Di Marco; Gokhan Zengin; Michele De Franco; Deepak Raj Pant; Mohamad Fawzi Mahomoodally; Nicola Ferri; Noemi Biancorosso; Filippo Maggi; Stefano Dall Acqua; Sangeeta Rajbhandary
Journal:  Molecules       Date:  2020-03-29       Impact factor: 4.411
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