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Literature DB >> 27308546

Tailoring combinatorial cancer therapies to target the origins of adaptive resistance.

Abstract

The development of resistance to chemotherapy is a critical yet poorly understood phenomenon driving cancer-related deaths. We recently reported a study that explored the origins of adaptive chemotherapy resistance. During this investigation we unexpectedly discovered that inherent vulnerabilities were unmasked, creating temporal targets for rational combinations of established drugs.

Entities: Disease

Keywords: adaptive resistance; cancer stem cells; computational biology; mathematical modeling; tumor heterogeneity

Year: 2015 PMID： 27308546 PMCID： PMC4845182 DOI： 10.1080/23723556.2015.1030534

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

1. Mutation selection and the natural history of cancer.

Authors: J Cairns
Journal: Nature Date: 1975-05-15 Impact factor: 49.962

2. Prospective identification of tumorigenic breast cancer cells.

Authors: Muhammad Al-Hajj; Max S Wicha; Adalberto Benito-Hernandez; Sean J Morrison; Michael F Clarke
Journal: Proc Natl Acad Sci U S A Date: 2003-03-10 Impact factor: 11.205

Review 3. Tumour stem cells and drug resistance.

Authors: Michael Dean; Tito Fojo; Susan Bates
Journal: Nat Rev Cancer Date: 2005-04 Impact factor: 60.716

Review 4. Triple-negative breast cancer: role of specific chemotherapy agents.

Authors: Steven J Isakoff
Journal: Cancer J Date: 2010 Jan-Feb Impact factor: 3.360

5. Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.

Authors: Biswanath Majumder; Ulaganathan Baraneedharan; Saravanan Thiyagarajan; Padhma Radhakrishnan; Harikrishna Narasimhan; Muthu Dhandapani; Nilesh Brijwani; Dency D Pinto; Arun Prasath; Basavaraja U Shanthappa; Allen Thayakumar; Rajagopalan Surendran; Govind K Babu; Ashok M Shenoy; Moni A Kuriakose; Guillaume Bergthold; Peleg Horowitz; Massimo Loda; Rameen Beroukhim; Shivani Agarwal; Shiladitya Sengupta; Mallikarjun Sundaram; Pradip K Majumder
Journal: Nat Commun Date: 2015-02-27 Impact factor: 14.919

6. Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition.

Authors: Aaron Goldman; Biswanath Majumder; Andrew Dhawan; Sudharshan Ravi; David Goldman; Mohammad Kohandel; Pradip K Majumder; Shiladitya Sengupta
Journal: Nat Commun Date: 2015-02-11 Impact factor: 14.919

Review 7. Tumour heterogeneity and cancer cell plasticity.

Authors: Corbin E Meacham; Sean J Morrison
Journal: Nature Date: 2013-09-19 Impact factor: 49.962

8. Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics.

Authors: E Colzani; A L V Johansson; A Liljegren; T Foukakis; M Clements; J Adolfsson; P Hall; K Czene
Journal: Br J Cancer Date: 2014-01-16 Impact factor: 7.640

9. Non-Darwinian dynamics in therapy-induced cancer drug resistance.

Authors: Angela Oliveira Pisco; Amy Brock; Joseph Zhou; Andreas Moor; Mitra Mojtahedi; Dean Jackson; Sui Huang
Journal: Nat Commun Date: 2013 Impact factor: 14.919

9 in total

4 in total

1. Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance.

Authors: Aaron Goldman; Sachin Khiste; Elizaveta Freinkman; Andrew Dhawan; Biswanath Majumder; Jayanta Mondal; Anthony B Pinkerton; Elliot Eton; Ragini Medhi; Vineethkrishna Chandrasekar; M Mamunur Rahman; Takaharu Ichimura; Kodaganur S Gopinath; Pradip Majumder; Mohammad Kohandel; Shiladitya Sengupta
Journal: Sci Signal Date: 2019-08-20 Impact factor: 8.192