Literature DB >> 27308540

GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling.

Heide Marika Genau1, Christian Behrends1.   

Abstract

Spatially restricted signaling is a hallmark of RAC1 signaling. Recent work has uncovered a novel role of gamma-aminobutyric acid receptor-associated proteins (GABARAPs), a subfamily of human ATG8 ubiquitin-like modifiers, in providing a scaffold for recruitment of an ubiquitin E3 ligase complex to its substrate, T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1), to enable ubiquitylation and thereby local control of RAC1 activity.

Entities:  

Keywords:  CUL3; KBTBD6; KBTBD7; LC3 and GABARAP proteins; TIAM1; spatially restricted signaling; ubiquitin

Year:  2015        PMID： 27308540      PMCID： PMC4845176          DOI： 10.1080/23723556.2015.1027440

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

Authors:  Heide Marika Genau; Jessica Huber; Francesco Baschieri; Masato Akutsu; Volker Dötsch; Hesso Farhan; Vladimir Rogov; Christian Behrends
Journal:  Mol Cell       Date:  2015-02-12       Impact factor: 17.970

2.  Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.

Authors:  Roberto Magliozzi; Jihoon Kim; Teck Yew Low; Albert J R Heck; Daniele Guardavaccaro
Journal:  J Biol Chem       Date:  2014-08-14       Impact factor: 5.157

3.  DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.

Authors:  Guixin Zhu; Zhongyun Fan; Miao Ding; Libing Mu; Juan Liang; Yajie Ding; Yu Fu; Binlu Huang; Wei Wu
Journal:  J Biol Chem       Date:  2014-04-15       Impact factor: 5.157

4.  Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.

Authors:  Philipp Wild; Hesso Farhan; David G McEwan; Sebastian Wagner; Vladimir V Rogov; Nathan R Brady; Benjamin Richter; Jelena Korac; Oliver Waidmann; Chunaram Choudhary; Volker Dötsch; Dirk Bumann; Ivan Dikic
Journal:  Science       Date:  2011-05-26       Impact factor: 47.728

5.  Recurrent R-spondin fusions in colon cancer.

Authors:  Somasekar Seshagiri; Eric W Stawiski; Steffen Durinck; Zora Modrusan; Elaine E Storm; Caitlin B Conboy; Subhra Chaudhuri; Yinghui Guan; Vasantharajan Janakiraman; Bijay S Jaiswal; Joseph Guillory; Connie Ha; Gerrit J P Dijkgraaf; Jeremy Stinson; Florian Gnad; Melanie A Huntley; Jeremiah D Degenhardt; Peter M Haverty; Richard Bourgon; Weiru Wang; Hartmut Koeppen; Robert Gentleman; Timothy K Starr; Zemin Zhang; David A Largaespada; Thomas D Wu; Frederic J de Sauvage
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

6.  LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis.

Authors:  Hilla Weidberg; Elena Shvets; Tomer Shpilka; Frida Shimron; Vera Shinder; Zvulun Elazar
Journal:  EMBO J       Date:  2010-04-23       Impact factor: 11.598

7.  The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy.

Authors:  Milton Osmar Aguilera; Walter Berón; María Isabel Colombo
Journal:  Autophagy       Date:  2012-08-06       Impact factor: 16.016

8.  HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.

Authors:  Lynsey Vaughan; Chong-Teik Tan; Anna Chapman; Daisuke Nonaka; Natalie A Mack; Duncan Smith; Richard Booton; Adam F L Hurlstone; Angeliki Malliri
Journal:  Cell Rep       Date:  2014-12-24       Impact factor: 9.423

9.  The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity.

Authors:  Anjana S Narayanan; Steve B Reyes; Kyongmi Um; Joseph H McCarty; Kimberley F Tolias
Journal:  Mol Biol Cell       Date:  2013-10-23       Impact factor: 4.138

Review 10.  Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms.

Authors:  Zhi Chen; Jie Sui; Fan Zhang; Caiguo Zhang
Journal:  J Cancer       Date:  2015-01-16       Impact factor: 4.207
  10 in total
  2 in total

1.  AIM/LIR-based fluorescent sensors-new tools to monitor mAtg8 functions.

Authors:  Katarzyna Zientara-Rytter; Suresh Subramani
Journal:  Autophagy       Date:  2018-05-11       Impact factor: 16.016

Review 2.  Spatial control of membrane traffic in neuronal dendrites.

Authors:  Megan R Radler; Ayana Suber; Elias T Spiliotis
Journal:  Mol Cell Neurosci       Date:  2020-04-12       Impact factor: 4.314
  2 in total

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