Literature DB >> 27308539

A novel role for the extended MYC network in cancer cell survival.

Patrick A Carroll1, Daniel Diolaiti1.   

Abstract

Cancer cells exhibit altered metabolic requirements compared to their normal counterparts. This metabolic reprogramming is mediated by activation of oncogenes such as MYC. Here, we summarize our recent findings demonstrating a metabolic dependency of deregulated MYC on MLXIP-MLX, critical components of the nutrient-sensing arm of the extended MYC transcriptional network.

Entities:  

Keywords:  MAX; MLXIP; MONDOA MLX; MYC; MYCN; cancer; glucose; lipid; metabolism

Year:  2015        PMID： 27308539      PMCID： PMC4845175          DOI： 10.1080/23723556.2015.1026528

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.

Authors:  Daniel Diolaiti; Lisa McFerrin; Patrick A Carroll; Robert N Eisenman
Journal:  Biochim Biophys Acta       Date:  2014-05-22

2.  Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.

Authors:  Patrick A Carroll; Daniel Diolaiti; Lisa McFerrin; Haiwei Gu; Danijel Djukovic; Jianhai Du; Pei Feng Cheng; Sarah Anderson; Michelle Ulrich; James B Hurley; Daniel Raftery; Donald E Ayer; Robert N Eisenman
Journal:  Cancer Cell       Date:  2015-01-29       Impact factor: 31.743

3.  MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival.

Authors:  Caroline M Wernicke; Günther H S Richter; Beate C Beinvogl; Stephanie Plehm; Anna M Schlitter; Obul R Bandapalli; Olivia Prazeres da Costa; Uwe E Hattenhorst; Ines Volkmer; Martin S Staege; Irene Esposito; Stefan Burdach; Thomas G P Grunewald
Journal:  Leuk Res       Date:  2012-06-29       Impact factor: 3.156

4.  Transcriptional amplification in tumor cells with elevated c-Myc.

Authors:  Charles Y Lin; Jakob Lovén; Peter B Rahl; Ronald M Paranal; Christopher B Burge; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

5.  The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation.

Authors:  Xuemei Tong; Fangping Zhao; Anthony Mancuso; Joshua J Gruber; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-07       Impact factor: 11.205

6.  OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.

Authors:  Nicole A Vasilevsky; Carl E Ruby; Peter J Hurlin; Andrew D Weinberg
Journal:  Eur J Immunol       Date:  2011-03-14       Impact factor: 5.532

7.  The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Authors:  Mariia O Yuneva; Teresa W M Fan; Thaddeus D Allen; Richard M Higashi; Dana V Ferraris; Takashi Tsukamoto; José M Matés; Francisco J Alonso; Chunmei Wang; Youngho Seo; Xin Chen; J Michael Bishop
Journal:  Cell Metab       Date:  2012-02-08       Impact factor: 27.287

8.  MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.

Authors:  Zhan Zhang; Hong Sun; Hongyue Dai; Ryan M Walsh; Maki Imakura; Janell Schelter; Julja Burchard; Xudong Dai; Aaron N Chang; Robert L Diaz; Joseph R Marszalek; Steven R Bartz; Michael Carleton; Michele A Cleary; Peter S Linsley; Carla Grandori
Journal:  Cell Cycle       Date:  2009-09-29       Impact factor: 4.534

Review 9.  An extended Myc network contributes to glucose homeostasis in cancer and diabetes.

Authors:  Christopher W Peterson; Donald E Ayer
Journal:  Front Biosci (Landmark Ed)       Date:  2011-06-01

10.  Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.

Authors:  Yun-Seung Jeong; Deokhoon Kim; Yong Seok Lee; Ha-Jung Kim; Jung-Youn Han; Seung-Soon Im; Hansook Kim Chong; Je-Keun Kwon; Yun-Ho Cho; Woo Kyung Kim; Timothy F Osborne; Jay D Horton; Hee-Sook Jun; Yong-Ho Ahn; Sung-Min Ahn; Ji-Young Cha
Journal:  PLoS One       Date:  2011-07-21       Impact factor: 3.240
  10 in total
  2 in total

Review 1.  Normal and Neoplastic Growth Suppression by the Extended Myc Network.

Authors:  Edward V Prochownik; Huabo Wang
Journal:  Cells       Date:  2022-02-21       Impact factor: 6.600

2.  Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia.

Authors:  Huabo Wang; Jie Lu; Frances Alencastro; Alexander Roberts; Julia Fiedor; Patrick Carroll; Robert N Eisenman; Sarangarajan Ranganathan; Michael Torbenson; Andrew W Duncan; Edward V Prochownik
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2022-03-05
  2 in total

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