Literature DB >> 27308534

The importance of integrated genomics to uncover clinically relevant cancer driver genes.

Xuelian Zhao1, Sonya Parpart-Li1, Xin Wei Wang1.   

Abstract

Tumor heterogeneity hinders the discovery of true cancer driver genes. The recently identified role for YY1-associated protein 1 (YY1AP1) as a critical oncoprotein that is activated in a particular subtype of hepatocellular carcinoma (HCC) was elucidated through integrative genomic profiling followed by functional studies. This strategy proved effective for finding a functional cancer driver with prognostic impact.

Entities:  

Year:  2015        PMID： 27308534      PMCID： PMC4845170          DOI： 10.1080/23723556.2015.1019975

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Applying the principles of stem-cell biology to cancer.

Authors:  Ricardo Pardal; Michael F Clarke; Sean J Morrison
Journal:  Nat Rev Cancer       Date:  2003-12       Impact factor: 60.716

Review 2.  Principles and methods of integrative genomic analyses in cancer.

Authors:  Vessela N Kristensen; Ole Christian Lingjærde; Hege G Russnes; Hans Kristian M Vollan; Arnoldo Frigessi; Anne-Lise Børresen-Dale
Journal:  Nat Rev Cancer       Date:  2014-05       Impact factor: 60.716

3.  The biological and clinical challenge of liver cancer heterogeneity.

Authors:  Xin Wei Wang; Snorri S Thorgeirsson
Journal:  Hepat Oncol       Date:  2014-12-11

4.  Intratumor heterogeneity: seeing the wood for the trees.

Authors:  Timothy A Yap; Marco Gerlinger; P Andrew Futreal; Lajos Pusztai; Charles Swanton
Journal:  Sci Transl Med       Date:  2012-03-28       Impact factor: 17.956

5.  Cancer. Addiction to oncogenes--the Achilles heal of cancer.

Authors:  I Bernard Weinstein
Journal:  Science       Date:  2002-07-05       Impact factor: 47.728

6.  EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.

Authors:  Taro Yamashita; Marshonna Forgues; Wei Wang; Jin Woo Kim; Qinghai Ye; Huliang Jia; Anuradha Budhu; Krista A Zanetti; Yidong Chen; Lun-Xiu Qin; Zhao-You Tang; Xin Wei Wang
Journal:  Cancer Res       Date:  2008-03-01       Impact factor: 12.701

7.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

8.  Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.

Authors:  X Zhao; S Parpart; A Takai; S Roessler; A Budhu; Z Yu; M Blank; Y E Zhang; H-L Jia; Q-H Ye; L-X Qin; Z-Y Tang; S S Thorgeirsson; X W Wang
Journal:  Oncogene       Date:  2015-01-19       Impact factor: 9.867

9.  Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Authors:  Petter S Woll; Una Kjällquist; Onima Chowdhury; Helen Doolittle; David C Wedge; Supat Thongjuea; Rikard Erlandsson; Mtakai Ngara; Kristina Anderson; Qiaolin Deng; Adam J Mead; Laura Stenson; Alice Giustacchini; Sara Duarte; Eleni Giannoulatou; Stephen Taylor; Mohsen Karimi; Christian Scharenberg; Teresa Mortera-Blanco; Iain C Macaulay; Sally-Ann Clark; Ingunn Dybedal; Dag Josefsen; Pierre Fenaux; Peter Hokland; Mette S Holm; Mario Cazzola; Luca Malcovati; Sudhir Tauro; David Bowen; Jacqueline Boultwood; Andrea Pellagatti; John E Pimanda; Ashwin Unnikrishnan; Paresh Vyas; Gudrun Göhring; Brigitte Schlegelberger; Magnus Tobiasson; Gunnar Kvalheim; Stefan N Constantinescu; Claus Nerlov; Lars Nilsson; Peter J Campbell; Rickard Sandberg; Elli Papaemmanuil; Eva Hellström-Lindberg; Sten Linnarsson; Sten Eirik W Jacobsen
Journal:  Cancer Cell       Date:  2014-05-15       Impact factor: 31.743

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
  10 in total

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