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Literature DB >> 27308531

Model organoids provide new research opportunities for ductal pancreatic cancer.

Sylvia F Boj¹, Chang-Il Hwang², Lindsey A Baker², Dannielle D Engle², David A Tuveson³, Hans Clevers⁴.

Abstract

We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.

Entities: Disease Species

Keywords: cancer; organoids; pancreatic ductal adenocarcinoma; preclinical models

Year: 2015 PMID： 27308531 PMCID： PMC4845167 DOI： 10.1080/23723556.2015.1014757

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

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5. Organoid models of human and mouse ductal pancreatic cancer.

Authors: Sylvia F Boj; Chang-Il Hwang; Lindsey A Baker; Iok In Christine Chio; Dannielle D Engle; Vincenzo Corbo; Myrthe Jager; Mariano Ponz-Sarvise; Hervé Tiriac; Mona S Spector; Ana Gracanin; Tobiloba Oni; Kenneth H Yu; Ruben van Boxtel; Meritxell Huch; Keith D Rivera; John P Wilson; Michael E Feigin; Daniel Öhlund; Abram Handly-Santana; Christine M Ardito-Abraham; Michael Ludwig; Ela Elyada; Brinda Alagesan; Giulia Biffi; Georgi N Yordanov; Bethany Delcuze; Brianna Creighton; Kevin Wright; Youngkyu Park; Folkert H M Morsink; I Quintus Molenaar; Inne H Borel Rinkes; Edwin Cuppen; Yuan Hao; Ying Jin; Isaac J Nijman; Christine Iacobuzio-Donahue; Steven D Leach; Darryl J Pappin; Molly Hammell; David S Klimstra; Olca Basturk; Ralph H Hruban; George Johan Offerhaus; Robert G J Vries; Hans Clevers; David A Tuveson
Journal: Cell Date: 2014-12-31 Impact factor: 41.582

6. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

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Journal: Nature Date: 2013-01-27 Impact factor: 49.962

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10. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

Authors: Meritxell Huch; Paola Bonfanti; Sylvia F Boj; Toshiro Sato; Cindy J M Loomans; Marc van de Wetering; Mozhdeh Sojoodi; Vivian S W Li; Jurian Schuijers; Ana Gracanin; Femke Ringnalda; Harry Begthel; Karien Hamer; Joyce Mulder; Johan H van Es; Eelco de Koning; Robert G J Vries; Harry Heimberg; Hans Clevers
Journal: EMBO J Date: 2013-09-17 Impact factor: 11.598

10 in total

22 in total

1. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.

Authors: Mirna Perusina Lanfranca; Yaqing Zhang; Alexander Girgis; Samantha Kasselman; Jenny Lazarus; Illona Kryczek; Lawrence Delrosario; Andrew Rhim; Lada Koneva; Maureen Sartor; Lei Sun; Christopher Halbrook; Hari Nathan; Jiaqi Shi; Howard C Crawford; Marina Pasca di Magliano; Weiping Zou; Timothy L Frankel
Journal: Gastroenterology Date: 2019-12-14 Impact factor: 22.682

Review 2. The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.

Authors: Anteneh A Tesfaye; Mandana Kamgar; Asfar Azmi; Philip A Philip
Journal: Expert Rev Anticancer Ther Date: 2017-12-19 Impact factor: 4.512

3. Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment.

Authors: Herve Tiriac; Juan Carlos Bucobo; Demetrios Tzimas; Suman Grewel; Joseph F Lacomb; Leahana M Rowehl; Satish Nagula; Maoxin Wu; Joseph Kim; Aaron Sasson; Shivakumar Vignesh; Laura Martello; Maria Munoz-Sagastibelza; Jonathan Somma; David A Tuveson; Ellen Li; Jonathan M Buscaglia
Journal: Gastrointest Endosc Date: 2018-01-09 Impact factor: 9.427

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Authors: Michaël Noë; Neda Rezaee; Kaushal Asrani; Michael Skaro; Vincent P Groot; Pei-Hsun Wu; Matthew T Olson; Seung-Mo Hong; Sung Joo Kim; Matthew J Weiss; Christopher L Wolfgang; Martin A Makary; Jin He; John L Cameron; Denis Wirtz; Nicholas J Roberts; G Johan A Offerhaus; Lodewijk A A Brosens; Laura D Wood; Ralph H Hruban
Journal: Am J Pathol Date: 2018-04-22 Impact factor: 4.307

10. Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids.

Authors: Anne-Laure Bulin; Mans Broekgaarden; Tayyaba Hasan
Journal: Sci Rep Date: 2017-11-30 Impact factor: 4.379