Literature DB >> 27308528

An expanded role for mTORC1 in autophagy.

Young-Mi Kim1, Ji-Man Park1, Douglas Grunwald1, Do-Hyung Kim2.   

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

Entities:  

Keywords:  RUBICON; UVRAG; autophagy; endosome; lysosome; mTOR; mTORC1

Year:  2015        PMID： 27308528      PMCID： PMC4845164          DOI： 10.1080/23723556.2015.1010958

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy.

Authors:  Helene Knævelsrud; Terje Ahlquist; Marianne A Merok; Arild Nesbakken; Harald Stenmark; Ragnhild A Lothe; Anne Simonsen
Journal:  Autophagy       Date:  2010-10-16       Impact factor: 16.016

2.  Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Authors:  Nao Hosokawa; Taichi Hara; Takeshi Kaizuka; Chieko Kishi; Akito Takamura; Yutaka Miura; Shun-ichiro Iemura; Tohru Natsume; Kenji Takehana; Naoyuki Yamada; Jun-Lin Guan; Noriko Oshiro; Noboru Mizushima
Journal:  Mol Biol Cell       Date:  2009-02-11       Impact factor: 4.138

3.  ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.

Authors:  Ian G Ganley; Du H Lam; Junru Wang; Xiaojun Ding; She Chen; Xuejun Jiang
Journal:  J Biol Chem       Date:  2009-03-03       Impact factor: 5.157

4.  Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

Authors:  Chengyu Liang; Jong-soo Lee; Kyung-soo Inn; Michaela U Gack; Qinglin Li; Esteban A Roberts; Isabelle Vergne; Vojo Deretic; Pinghui Feng; Chihiro Akazawa; Jae U Jung
Journal:  Nat Cell Biol       Date:  2008-06-15       Impact factor: 28.824

5.  mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

Authors:  Young-Mi Kim; Chang Hwa Jung; Minchul Seo; Eun Kyoung Kim; Ji-Man Park; Sun Sik Bae; Do-Hyung Kim
Journal:  Mol Cell       Date:  2014-12-18       Impact factor: 17.970

6.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors:  Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal:  Nat Cell Biol       Date:  2011-01-23       Impact factor: 28.824

7.  Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability.

Authors:  Min Sung Kim; Eun Goo Jeong; Chang Hyeok Ahn; Sung Soo Kim; Sug Hyung Lee; Nam Jin Yoo
Journal:  Hum Pathol       Date:  2008-05-20       Impact factor: 3.466

8.  ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

Authors:  Chang Hwa Jung; Chang Bong Jun; Seung-Hyun Ro; Young-Mi Kim; Neil Michael Otto; Jing Cao; Mondira Kundu; Do-Hyung Kim
Journal:  Mol Biol Cell       Date:  2009-02-18       Impact factor: 4.138

9.  Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

Authors:  Eisuke Itakura; Chieko Kishi; Kinji Inoue; Noboru Mizushima
Journal:  Mol Biol Cell       Date:  2008-10-08       Impact factor: 4.138

10.  PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

Authors:  Shanshan He; Duojiao Ni; Binyun Ma; Joo-Hyung Lee; Tian Zhang; Irene Ghozalli; Sara Dolatshahi Pirooz; Zhen Zhao; Nagakumar Bharatham; Baihong Li; Soohwan Oh; Wen-Hwa Lee; Yoshinori Takahashi; Hong-Gang Wang; Arlet Minassian; Pinghui Feng; Vojo Deretic; Rainer Pepperkok; Mitsuo Tagaya; Ho Sup Yoon; Chengyu Liang
Journal:  Nat Cell Biol       Date:  2013-09-22       Impact factor: 28.824
  10 in total
  2 in total

Review 1.  The Evolving Landscape of Cutaneous Sarcoidosis: Pathogenic Insight, Clinical Challenges, and New Frontiers in Therapy.

Authors:  Julie H Wu; Sotonye Imadojemu; Avrom S Caplan
Journal:  Am J Clin Dermatol       Date:  2022-05-18       Impact factor: 6.233

2.  TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex.

Authors:  P Guo; X Ma; W Zhao; W Huai; T Li; Y Qiu; Y Zhang; L Han
Journal:  Oncogene       Date:  2017-10-02       Impact factor: 9.867
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.