Literature DB >> 27308525

Regulation of hematopoietic progenitors by estrogens as a basis for new antileukemic strategies.

Abel Sánchez-Aguilera1, Simón Méndez-Ferrer1.   

Abstract

We recently reported that estrogens regulate survival, proliferation, and self-renewal of hematopoietic stem cells and progenitors via estrogen receptor-α activation. Through its proapoptotic effect on malignant progenitors, tamoxifen treatment blocks the development of JAK2 (V617F) -induced myeloproliferative neoplasms in mice and sensitizes MLL-AF9-induced leukemias to chemotherapy, without detrimental effects on normal hematopoiesis.

Entities:  

Keywords:  JAK2; MLL-AF9; acute myeloid leukemia; estrogen receptors; estrogens; hematopoietic progenitor cells; hematopoietic stem cells; myeloproliferative neoplasms; selective estrogen receptor modulators; tamoxifen

Year:  2015        PMID： 27308525      PMCID： PMC4845161          DOI： 10.1080/23723556.2015.1009728

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen.

Authors:  K L Medina; K P Garrett; L F Thompson; M I Rossi; K J Payne; P W Kincade
Journal:  Nat Immunol       Date:  2001-08       Impact factor: 25.606

2.  Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.

Authors:  Anett Illing; Peng Liu; Susanne Ostermay; Arndt Schilling; Gerald de Haan; Andree Krust; Michael Amling; Pierre Chambon; Thorsten Schinke; Jan P Tuckermann
Journal:  Haematologica       Date:  2012-02-27       Impact factor: 9.941

3.  Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure.

Authors:  Paula I Moreira; José Custódio; António Moreno; Catarina R Oliveira; Maria S Santos
Journal:  J Biol Chem       Date:  2006-01-12       Impact factor: 5.157

4.  Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.

Authors:  Abel Sánchez-Aguilera; Lorena Arranz; Daniel Martín-Pérez; Andrés García-García; Vaia Stavropoulou; Lucia Kubovcakova; Joan Isern; Sandra Martín-Salamanca; Xavier Langa; Radek C Skoda; Jürg Schwaller; Simón Méndez-Ferrer
Journal:  Cell Stem Cell       Date:  2014-12-04       Impact factor: 24.633

Review 5.  Mechanisms of tamoxifen-induced apoptosis.

Authors:  S Mandlekar; A N Kong
Journal:  Apoptosis       Date:  2001-12       Impact factor: 4.677

6.  Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.

Authors:  Ralph Tiedt; Hui Hao-Shen; Marta A Sobas; Renate Looser; Stephan Dirnhofer; Jürg Schwaller; Radek C Skoda
Journal:  Blood       Date:  2007-12-26       Impact factor: 22.113

7.  Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.

Authors:  Daisuke Nakada; Hideyuki Oguro; Boaz P Levi; Nicole Ryan; Ayumi Kitano; Yusuke Saitoh; Makiko Takeichi; George R Wendt; Sean J Morrison
Journal:  Nature       Date:  2014-01-23       Impact factor: 49.962

8.  Inhibition of lymphoma vascularization and dissemination by estrogen receptor β agonists.

Authors:  Konstantin Yakimchuk; Mohammad Sharif Hasni; Jiyu Guan; Mark P Chao; Birgitta Sander; Sam Okret
Journal:  Blood       Date:  2014-01-27       Impact factor: 22.113
  8 in total
  6 in total

1.  Repurposing Antiestrogens for Tumor Immunotherapy.

Authors:  Thomas Welte; Xiang H-F Zhang; Jeffrey M Rosen
Journal:  Cancer Discov       Date:  2017-01       Impact factor: 39.397

Review 2.  Bone marrow niches in haematological malignancies.

Authors:  Simón Méndez-Ferrer; Dominique Bonnet; David P Steensma; Robert P Hasserjian; Irene M Ghobrial; John G Gribben; Michael Andreeff; Daniela S Krause
Journal:  Nat Rev Cancer       Date:  2020-02-28       Impact factor: 60.716

3.  The Epidemiological Trend of Acute Myeloid Leukemia in Childhood: a Population-Based Analysis.

Authors:  Xuanwei Chen; Jianwei Pan; Shuncong Wang; Shandie Hong; Shunrong Hong; Shaoru He
Journal:  J Cancer       Date:  2019-08-27       Impact factor: 4.207

Review 4.  Estrogen Receptors Alpha and Beta in Acute Myeloid Leukemia.

Authors:  Alessia Roma; Paul A Spagnuolo
Journal:  Cancers (Basel)       Date:  2020-04-08       Impact factor: 6.639

5.  Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis.

Authors:  Guangli Li; Zhijuan Zhou; Wencong Yang; Hao Yang; Xiuwu Fan; Yuelan Yin; Liyun Luo; Jinyou Zhang; Niujian Wu; Zibin Liang; Jianting Ke; Jian Chen
Journal:  J Cancer       Date:  2019-10-15       Impact factor: 4.207

6.  The G-Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Proliferation and Causes Apoptosis in Leukemia Cell Lines of T Lineage.

Authors:  Liliana Torres-López; Miguel Olivas-Aguirre; Kathya Villatoro-Gómez; Oxana Dobrovinskaya
Journal:  Front Cell Dev Biol       Date:  2022-02-14
  6 in total

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