Literature DB >> 27308517

MKP1 mediates resistance to therapy in HER2-positive breast tumors.

Demet Candas1, Jian Jian Li1.   

Abstract

Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.

Entities:  

Keywords:  HER2; MKP1; breast cancer; mitochondria; radioresistance

Year:  2015        PMID： 27308517      PMCID： PMC4905363          DOI： 10.1080/23723556.2014.997518

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  7 in total

1.  Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.

Authors:  S Kharbanda; S Saxena; K Yoshida; P Pandey; M Kaneki; Q Wang; K Cheng; Y N Chen; A Campbell; T Sudha; Z M Yuan; J Narula; R Weichselbaum; C Nalin; D Kufe
Journal:  J Biol Chem       Date:  2000-01-07       Impact factor: 5.157

2.  Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.

Authors:  Demet Candas; Chung-Ling Lu; Ming Fan; Frank Y S Chuang; Colleen Sweeney; Alexander D Borowsky; Jian Jian Li
Journal:  Cancer Res       Date:  2014-11-06       Impact factor: 12.701

Review 3.  The biology of human epidermal growth factor receptor 2.

Authors:  S Sundaresan; E Penuel; M X Sliwkowski
Journal:  Curr Oncol Rep       Date:  1999-09       Impact factor: 5.075

4.  Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer.

Authors:  Hsien-yu Wang; Zhiyong Cheng; Craig C Malbon
Journal:  Cancer Lett       Date:  2003-03-10       Impact factor: 8.679

5.  HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells.

Authors:  Nadire Duru; Ming Fan; Demet Candas; Cheikh Menaa; Hsin-Chen Liu; Danupon Nantajit; Yunfei Wen; Kai Xiao; Angela Eldridge; Brett A Chromy; Shiyong Li; Douglas R Spitz; Kit S Lam; Max S Wicha; Jian Jian Li
Journal:  Clin Cancer Res       Date:  2012-10-22       Impact factor: 12.531

Review 6.  Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.

Authors:  Tarek Boutros; Eric Chevet; Peter Metrakos
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

7.  Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation.

Authors:  Zhaoqing Wang; Ning Cao; Danupon Nantajit; Ming Fan; Yusen Liu; Jian Jian Li
Journal:  J Biol Chem       Date:  2008-05-27       Impact factor: 5.157
  7 in total
  4 in total

1.  DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.

Authors:  Qinhua Jin; Ruibing Li; Nan Hu; Ting Xin; Pingjun Zhu; Shunying Hu; Sai Ma; Hong Zhu; Jun Ren; Hao Zhou
Journal:  Redox Biol       Date:  2017-11-06       Impact factor: 11.799

2.  DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer.

Authors:  Fei Teng; Zhiyuan Xu; Jiahui Chen; Guowei Zheng; Guodian Zheng; Hang Lv; Yiping Wang; Lijing Wang; Xiangdong Cheng
Journal:  Oncol Rep       Date:  2018-06-25       Impact factor: 3.906

3.  Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.

Authors:  Fang He; Zheqian Wu; Yong Wang; Lili Yin; Shijie Lu; Lihua Dai
Journal:  Cell Biol Int       Date:  2021-11-10       Impact factor: 4.473

4.  Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells.

Authors:  Asmita Sharda; Mudasir Rashid; Sanket Girish Shah; Ajit Kumar Sharma; Saurav Raj Singh; Poonam Gera; Murali Krishna Chilkapati; Sanjay Gupta
Journal:  Clin Epigenetics       Date:  2020-01-03       Impact factor: 6.551
  4 in total

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