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Literature DB >> 27308511

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression.

Yelena Kravtsova-Ivantsiv¹, Aaron Ciechanover¹.

Abstract

The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50-p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.

Entities: Disease Gene

Keywords: 26S proteasome; KPC1; NF-κB; p105; tumor growth regulation; ubiquitin

Year: 2015 PMID： 27308511 PMCID： PMC4905413 DOI： 10.1080/23723556.2015.1054552

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

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Journal: EMBO J Date: 2000-06-01 Impact factor: 11.598

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Journal: Mol Cell Biol Date: 2001-02 Impact factor: 4.272

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Authors: Kazuhiro Iwai
Journal: Biochim Biophys Acta Date: 2013-03-21

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Authors: Kazuhiro Iwai; Hiroaki Fujita; Yoshiteru Sasaki
Journal: Nat Rev Mol Cell Biol Date: 2014-07-09 Impact factor: 94.444

Review 5. NF-κB and the link between inflammation and cancer.

Authors: Joseph A DiDonato; Frank Mercurio; Michael Karin
Journal: Immunol Rev Date: 2012-03 Impact factor: 12.988

6. Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.

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Journal: J Biol Chem Date: 2001-04-10 Impact factor: 5.157

7. KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.

Authors: Yelena Kravtsova-Ivantsiv; Inna Shomer; Victoria Cohen-Kaplan; Berend Snijder; Giulio Superti-Furga; Hedva Gonen; Thomas Sommer; Tamar Ziv; Arie Admon; Inna Naroditsky; Muhammad Jbara; Ashraf Brik; Eli Pikarsky; Yong Tae Kwon; Ilana Doweck; Aaron Ciechanover
Journal: Cell Date: 2015-04-09 Impact factor: 41.582

8. Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway.

Authors: C M Fan; T Maniatis
Journal: Nature Date: 1991-12-05 Impact factor: 49.962

9. Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.

Authors: A Orian; S Whiteside; A Israël; I Stancovski; A L Schwartz; A Ciechanover
Journal: J Biol Chem Date: 1995-09-15 Impact factor: 5.157

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Authors: Neil D Perkins
Journal: Nat Rev Cancer Date: 2012-01-19 Impact factor: 60.716

10 in total

12 in total

1. Target therapy of TRIM-14 inhibits osteosarcoma aggressiveness through the nuclear factor-κB signaling pathway.

Authors: Yi-Jiong Li; Guo-Ping Zhang; Feng Zhao; Rui-Qi Li; Shao-Jun Liu; Zeng-Ren Zhao; Xin Wang
Journal: Exp Ther Med Date: 2017-12-27 Impact factor: 2.447

2. Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors.

Authors: Xiaowen Wang; Matias A Bustos; Xiaoqing Zhang; Romela Irene Ramos; Cong Tan; Yuuki Iida; Shu-Ching Chang; Matthew P Salomon; Kevin Tran; Rebecca Gentry; Yelena Kravtsova-Ivantsiv; Daniel F Kelly; Gordon B Mills; Aaron Ciechanover; Ying Mao; Dave S B Hoon
Journal: Cancers (Basel) Date: 2020-04-27 Impact factor: 6.639

3. KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation.

Authors: Ye Yuan; Yong-Yi Wang; Xin Liu; Bin Luo; Lei Zhang; Fei Zheng; Xing-Yuan Li; Ling-Yun Guo; Lu Wang; Miao Jiang; Ya-Mu Pan; Yu-Wen Yan; Jian-Ye Yang; Shi-You Chen; Jia-Ning Wang; Jun-Ming Tang
Journal: J Cell Physiol Date: 2019-05-30 Impact factor: 6.384

4. A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility.

Authors: Weizhe Li; Jinqing Liang; Patricia Outeda; Stacey Turner; Barbara T Wakimoto; Terry Watnick
Journal: PLoS Genet Date: 2020-12-30 Impact factor: 5.917

5. Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.

Authors: Miaomiao Qi; Xiang Liu; Ying Zhou; Haoyu Wang; Ying Zhao; Jing Ren; Jin Xiang
Journal: Int J Mol Sci Date: 2021-10-24 Impact factor: 5.923

6. Response: Commentary: An In Silico-In Vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients.

Authors: Michele Mishto; Guillermo Rodriguez-Hernandez; Jacques Neefjes; Henning Urlaub; Juliane Liepe
Journal: Front Immunol Date: 2021-07-13 Impact factor: 7.561

10. Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network.

Authors: Sinemyiz Atalay; Agnieszka Gęgotek; Pedro Domingues; Elżbieta Skrzydlewska
Journal: Redox Biol Date: 2021-07-17 Impact factor: 11.799