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Literature DB >> 27308509

HIGD1A-mediated dormancy and tumor survival.

Abstract

Solid tumors contain regions of anoxia that are also glucose deprived. How cancer cells survive such extreme conditions remains unclear. Here, we discuss our recent findings that regulation of hypoxia inducible gene domain family member 1 A (HIGD1A) via epigenetic mechanisms during glucose starvation modulates oxygen consumption and reactive oxygen species production to enable tumor cell survival through the activation of dormancy mechanisms.

Entities: Chemical Disease Gene

Keywords: AMPK; DNMT1; HIF; glucose deprivation; hypoxia; tumor dormancy

Year: 2015 PMID： 27308509 PMCID： PMC4905353 DOI： 10.1080/23723556.2015.1030537

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

Review 1. Famine versus feast: understanding the metabolism of tumors in vivo.

Authors: Jared R Mayers; Matthew G Vander Heiden
Journal: Trends Biochem Sci Date: 2015-01-29 Impact factor: 13.807

2. Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization.

Authors: Mayuko Osada-Oka; Yasushi Hashiba; Satoshi Akiba; Susumu Imaoka; Takashi Sato
Journal: FEBS Lett Date: 2010-06-01 Impact factor: 4.124

Review 3. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.

Authors: Nicholas McGranahan; Charles Swanton
Journal: Cancer Cell Date: 2015-01-12 Impact factor: 31.743

4. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.

Authors: Hsing-Chen Tsai; Huili Li; Leander Van Neste; Yi Cai; Carine Robert; Feyruz V Rassool; James J Shin; Kirsten M Harbom; Robert Beaty; Emmanouil Pappou; James Harris; Ray-Whay Chiu Yen; Nita Ahuja; Malcolm V Brock; Vered Stearns; David Feller-Kopman; Lonny B Yarmus; Yi-Chun Lin; Alana L Welm; Jean-Pierre Issa; Il Minn; William Matsui; Yoon-Young Jang; Saul J Sharkis; Stephen B Baylin; Cynthia A Zahnow
Journal: Cancer Cell Date: 2012-03-20 Impact factor: 31.743

Review 5. Regulation of tumor cell dormancy by tissue microenvironments and autophagy.

Authors: Maria Soledad Sosa; Paloma Bragado; Jayanta Debnath; Julio A Aguirre-Ghiso
Journal: Adv Exp Med Biol Date: 2013 Impact factor: 2.622

6. Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.

Authors: Steffen Lindert; Innokentiy Maslennikov; Ellis J C Chiu; Levi C Pierce; J Andrew McCammon; Senyon Choe
Journal: Biochem Biophys Res Commun Date: 2014-02-10 Impact factor: 3.575

7. Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors.

Authors: Solmaz Sobhanifar; Christina Aquino-Parsons; Eric J Stanbridge; Peggy Olive
Journal: Cancer Res Date: 2005-08-15 Impact factor: 12.701

Review 8. Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality.

Authors: Alan McIntyre; Adrian L Harris
Journal: EMBO Mol Med Date: 2015-04 Impact factor: 12.137

9. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.

Authors: Kurosh Ameri; Arman Jahangiri; Anthony M Rajah; Kathryn V Tormos; Ravi Nagarajan; Melike Pekmezci; Vien Nguyen; Matthew L Wheeler; Michael P Murphy; Timothy A Sanders; Stefanie S Jeffrey; Yerem Yeghiazarians; Paolo F Rinaudo; Joseph F Costello; Manish K Aghi; Emin Maltepe
Journal: Cell Rep Date: 2015-02-13 Impact factor: 9.423

10. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.

Authors: Kurosh Ameri; Anthony M Rajah; Vien Nguyen; Timothy A Sanders; Arman Jahangiri; Michael Delay; Matthew Donne; Hwa J Choi; Kathryn V Tormos; Yerem Yeghiazarians; Stefanie S Jeffrey; Paolo F Rinaudo; David H Rowitch; Manish Aghi; Emin Maltepe
Journal: PLoS One Date: 2013-04-30 Impact factor: 3.240

10 in total

5 in total

1. The yeast mitochondrial proteins Rcf1 and Rcf2 support the enzymology of the cytochrome c oxidase complex and generation of the proton motive force.

Authors: Vera Strogolova; Ngoc H Hoang; Jonathan Hosler; Rosemary A Stuart
Journal: J Biol Chem Date: 2019-01-25 Impact factor: 5.157