Literature DB >> 27308486

SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR.

Andrei V Budanov1.   

Abstract

SESTRINs, proteins encoded by the SESN1-3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent studies support the RRAGA/B-dependence of mTORC1 regulation by SESTRINs; however, the role of GATOR2 in this process requires clarification.

Entities:  

Keywords:  GATOR; GID; RRAG-A/B; SESTRINs; mTORC1

Year:  2015        PMID： 27308486      PMCID： PMC4905323          DOI： 10.1080/23723556.2014.997113

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

2.  The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

Authors:  Lynne Chantranupong; Rachel L Wolfson; Jose M Orozco; Robert A Saxton; Sonia M Scaria; Liron Bar-Peled; Eric Spooner; Marta Isasa; Steven P Gygi; David M Sabatini
Journal:  Cell Rep       Date:  2014-09-25       Impact factor: 9.423

3.  A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.

Authors:  Svetlana Dokudovskaya; Francois Waharte; Avner Schlessinger; Ursula Pieper; Damien P Devos; Ileana M Cristea; Rosemary Williams; Jean Salamero; Brian T Chait; Andrej Sali; Mark C Field; Michael P Rout; Catherine Dargemont
Journal:  Mol Cell Proteomics       Date:  2011-03-31       Impact factor: 5.911

Review 4.  Regulation of mTORC1 by amino acids.

Authors:  Liron Bar-Peled; David M Sabatini
Journal:  Trends Cell Biol       Date:  2014-03-31       Impact factor: 20.808

5.  Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

Authors:  Min Peng; Na Yin; Ming O Li
Journal:  Cell       Date:  2014-09-25       Impact factor: 41.582

6.  Sestrins inhibit mTORC1 kinase activation through the GATOR complex.

Authors:  Anita Parmigiani; Aida Nourbakhsh; Boxiao Ding; Wei Wang; Young Chul Kim; Konstantin Akopiants; Kun-Liang Guan; Michael Karin; Andrei V Budanov
Journal:  Cell Rep       Date:  2014-11-20       Impact factor: 9.423

Review 7.  Stressin' Sestrins take an aging fight.

Authors:  Andrei V Budanov; Jun Hee Lee; Michael Karin
Journal:  EMBO Mol Med       Date:  2010-10       Impact factor: 12.137

8.  Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.

Authors:  Noriko Oshiro; Joseph Rapley; Joseph Avruch
Journal:  J Biol Chem       Date:  2013-12-11       Impact factor: 5.157

9.  p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.

Authors:  Andrei V Budanov; Michael Karin
Journal:  Cell       Date:  2008-08-08       Impact factor: 41.582

10.  SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation.

Authors:  Nicolas Panchaud; Marie-Pierre Péli-Gulli; Claudio De Virgilio
Journal:  Cell Cycle       Date:  2013-08-13       Impact factor: 4.534
  10 in total
  6 in total

1.  A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Authors:  James A Timmons; Philip J Atherton; Ola Larsson; Sanjana Sood; Ilya O Blokhin; Robert J Brogan; Claude-Henry Volmar; Andrea R Josse; Cris Slentz; Claes Wahlestedt; Stuart M Phillips; Bethan E Phillips; Iain J Gallagher; William E Kraus
Journal:  Nucleic Acids Res       Date:  2018-09-06       Impact factor: 16.971

2.  p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.

Authors:  Boxiao Ding; Alexander Haidurov; Ayesha Chawla; Anita Parmigiani; Gerarda van de Kamp; Alexandra Dalina; Fang Yuan; Jun Hee Lee; Peter M Chumakov; Steven R Grossman; Andrei V Budanov
Journal:  Oncotarget       Date:  2019-12-10

3.  SESN1 attenuates the Ox‑LDL‑induced inflammation, apoptosis and endothelial‑mesenchymal transition of human umbilical vein endothelial cells by regulating AMPK/SIRT1/LOX1 signaling.

Authors:  Feng Gao; Yongcheng Zhao; Bin Zhang; Chunwei Xiao; Zhanfa Sun; Yuan Gao; Xueyong Dou
Journal:  Mol Med Rep       Date:  2022-03-16       Impact factor: 3.423

4.  Mitochondrial AKAP1 supports mTOR pathway and tumor growth.

Authors:  Laura Rinaldi; Maria Sepe; Rossella Delle Donne; Kristel Conte; Antonietta Arcella; Domenica Borzacchiello; Stefano Amente; Fernanda De Vita; Monia Porpora; Corrado Garbi; Maria A Oliva; Claudio Procaccini; Deriggio Faicchia; Giuseppe Matarese; Federica Zito Marino; Gaetano Rocco; Sara Pignatiello; Renato Franco; Luigi Insabato; Barbara Majello; Antonio Feliciello
Journal:  Cell Death Dis       Date:  2017-06-01       Impact factor: 8.469

5.  Mitochondrial localization of SESN2.

Authors:  Irina E Kovaleva; Artem V Tokarchuk; Andrei O Zheltukhin; Alexandra A Dalina; Grigoriy G Safronov; Alexandra G Evstafieva; Konstantin G Lyamzaev; Peter M Chumakov; Andrei V Budanov
Journal:  PLoS One       Date:  2020-04-14       Impact factor: 3.240

6.  Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge.

Authors:  Jia Zhao; Lixing Lao; Wei Cui; Jianhui Rong
Journal:  J Neuroinflammation       Date:  2019-11-11       Impact factor: 8.322
  6 in total

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