Literature DB >> 27308485

The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer.

Lloye M Dillon1, Todd W Miller2.   

Abstract

PREX1 is a Rac guanine exchange factor that coordinates signaling inputs from G protein-coupled receptors and receptor tyrosine kinases (RTKs). PREX1 creates a positive feedback loop to drive RTK, phosphatidylinositol 3-kinase (PI3K)/AKT, and MEK/ERK signaling. High PREX1 levels predict sensitivity to PI3K inhibitors in breast cancer cells.

Entities:  

Keywords:  MEK; P-REX1; PI3K; breast cancer

Year:  2015        PMID： 27308485      PMCID： PMC4905322          DOI： 10.1080/23723556.2014.996016

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

Authors:  Heidi C E Welch; W John Coadwell; Christian D Ellson; G John Ferguson; Simon R Andrews; Hediye Erdjument-Bromage; Paul Tempst; Phillip T Hawkins; Len R Stephens
Journal:  Cell       Date:  2002-03-22       Impact factor: 41.582

2.  Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Authors:  Maria Soledad Sosa; Cynthia Lopez-Haber; Chengfeng Yang; Hongbin Wang; Mark A Lemmon; John M Busillo; Jiansong Luo; Jeffrey L Benovic; Andres Klein-Szanto; Hiroshi Yagi; J Silvio Gutkind; Ramon E Parsons; Marcelo G Kazanietz
Journal:  Mol Cell       Date:  2010-12-22       Impact factor: 17.970

3.  PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

Authors:  Hiromichi Ebi; Carlotta Costa; Anthony C Faber; Madhuri Nishtala; Hiroshi Kotani; Dejan Juric; Patricia Della Pelle; Youngchul Song; Seiji Yano; Mari Mino-Kenudson; Cyril H Benes; Jeffrey A Engelman
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-10       Impact factor: 11.205

4.  Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling.

Authors:  Marie Will; Alice Can Ran Qin; Weiyi Toy; Zhan Yao; Vanessa Rodrik-Outmezguine; Claudia Schneider; Xiaodong Huang; Prashant Monian; Xuejun Jiang; Elisa de Stanchina; José Baselga; Ningshu Liu; Sarat Chandarlapaty; Neal Rosen
Journal:  Cancer Discov       Date:  2014-01-16       Impact factor: 39.397

5.  Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Authors:  Barry Fine; Cindy Hodakoski; Susan Koujak; Tao Su; Lao H Saal; Matthew Maurer; Benjamin Hopkins; Megan Keniry; Maria Luisa Sulis; Sarah Mense; Hanina Hibshoosh; Ramon Parsons
Journal:  Science       Date:  2009-09-04       Impact factor: 47.728

6.  PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.

Authors:  Jill K Slack-Davis; Scott T Eblen; Maja Zecevic; Scott A Boerner; Adel Tarcsafalvi; H Bruce Diaz; Mark S Marshall; Michael J Weber; J Thomas Parsons; Andrew D Catling
Journal:  J Cell Biol       Date:  2003-07-21       Impact factor: 10.539

7.  P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.

Authors:  L M Dillon; J R Bean; W Yang; K Shee; L K Symonds; J M Balko; W H McDonald; S Liu; A M Gonzalez-Angulo; G B Mills; C L Arteaga; T W Miller
Journal:  Oncogene       Date:  2014-10-06       Impact factor: 9.867

8.  RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.

Authors:  Ralph Fritsch; Inge de Krijger; Kornelia Fritsch; Roger George; Beth Reason; Madhu S Kumar; Markus Diefenbacher; Gordon Stamp; Julian Downward
Journal:  Cell       Date:  2013-05-23       Impact factor: 41.582
  8 in total
  5 in total

Review 1.  The Rac GTPase in Cancer: From Old Concepts to New Paradigms.

Authors:  Marcelo G Kazanietz; Maria J Caloca
Journal:  Cancer Res       Date:  2017-08-14       Impact factor: 12.701

Review 2.  The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic.

Authors:  Victoria Casado-Medrano; Martin J Baker; Cynthia Lopez-Haber; Mariana Cooke; Shaofei Wang; Maria J Caloca; Marcelo G Kazanietz
Journal:  Biochem Soc Trans       Date:  2018-07-31       Impact factor: 5.407

3.  Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing.

Authors:  Hyun Jee Kim; Minho Lee; Young Bok Lee; Dong Soo Yu
Journal:  Acta Derm Venereol       Date:  2021-05-19       Impact factor: 3.875

4.  Searching for a signature involving 10 genes to predict the survival of patients with acute myelocytic leukemia through a combined multi-omics analysis.

Authors:  Haifeng Zhuang; Yu Chen; Xianfu Sheng; Lili Hong; Ruilan Gao; Xiaofen Zhuang
Journal:  PeerJ       Date:  2020-06-25       Impact factor: 2.984

5.  P-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis.

Authors:  Qing Liang; Yanhua Chang; Jing Liu; Yan Yu; Wancheng Qiu; Jiajia Li; Xu Yang; Guangchun Sun
Journal:  Front Pharmacol       Date:  2021-07-19       Impact factor: 5.810
  5 in total

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