Literature DB >> 27308448

Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide.

Paolo E Porporato1, Pierre Sonveaux1.   

Abstract

Metastatic dissemination is associated with poor prognosis of cancer patients. While exploring glucose metabolism in metastatic progenitor cells, we recently found that several different dysfunctions that share the ability to induce mitochondrial superoxide production also promote tumor metastasis. Selective targeting of mitochondrial superoxide prevented spontaneous metastasis in mice, opening a new avenue for therapy.

Entities:  

Keywords:  ROS; Warburg effect; cancer; metastasis; metastasis prevention; mitochondria; superoxide

Year:  2014        PMID： 27308448      PMCID： PMC4905283          DOI： 10.4161/23723548.2014.968043

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  A mitochondrial switch promotes tumor metastasis.

Authors:  Paolo E Porporato; Valéry L Payen; Jhudit Pérez-Escuredo; Christophe J De Saedeleer; Pierre Danhier; Tamara Copetti; Suveera Dhup; Morgane Tardy; Thibaut Vazeille; Caroline Bouzin; Olivier Feron; Carine Michiels; Bernard Gallez; Pierre Sonveaux
Journal:  Cell Rep       Date:  2014-07-24       Impact factor: 9.423

Review 2.  Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

Authors:  Patrick S Ward; Craig B Thompson
Journal:  Cancer Cell       Date:  2012-03-20       Impact factor: 31.743

3.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.

Authors:  Frank Weinberg; Robert Hamanaka; William W Wheaton; Samuel Weinberg; Joy Joseph; Marcos Lopez; Balaraman Kalyanaraman; Gökhan M Mutlu; G R Scott Budinger; Navdeep S Chandel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-26       Impact factor: 11.205

4.  TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer.

Authors:  M K Wendt; B J Schiemann; J G Parvani; Y-H Lee; Y Kang; W P Schiemann
Journal:  Oncogene       Date:  2012-06-18       Impact factor: 9.867

5.  Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.

Authors:  Kim Zarse; Sebastian Schmeisser; Marco Groth; Steffen Priebe; Gregor Beuster; Doreen Kuhlow; Reinhard Guthke; Matthias Platzer; C Ronald Kahn; Michael Ristow
Journal:  Cell Metab       Date:  2012-04-04       Impact factor: 27.287

6.  ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Authors:  Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi
Journal:  Science       Date:  2008-04-03       Impact factor: 47.728

7.  Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

Authors:  Pierre Sonveaux; Frédérique Végran; Thies Schroeder; Melanie C Wergin; Julien Verrax; Zahid N Rabbani; Christophe J De Saedeleer; Kelly M Kennedy; Caroline Diepart; Bénédicte F Jordan; Michael J Kelley; Bernard Gallez; Miriam L Wahl; Olivier Feron; Mark W Dewhirst
Journal:  J Clin Invest       Date:  2008-11-20       Impact factor: 14.808

8.  Antioxidants accelerate lung cancer progression in mice.

Authors:  Volkan I Sayin; Mohamed X Ibrahim; Erik Larsson; Jonas A Nilsson; Per Lindahl; Martin O Bergo
Journal:  Sci Transl Med       Date:  2014-01-29       Impact factor: 17.956

Review 9.  Defects in mitochondrial metabolism and cancer.

Authors:  Edoardo Gaude; Christian Frezza
Journal:  Cancer Metab       Date:  2014-07-17
  9 in total
  11 in total

Review 1.  Defining the Hallmarks of Metastasis.

Authors:  Danny R Welch; Douglas R Hurst
Journal:  Cancer Res       Date:  2019-05-03       Impact factor: 12.701

Review 2.  Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism.

Authors:  Paolo E Porporato; Valéry L Payen; Bjorn Baselet; Pierre Sonveaux
Journal:  Cell Mol Life Sci       Date:  2015-12-08       Impact factor: 9.261

Review 3.  Cancer cell metabolic plasticity in migration and metastasis.

Authors:  Jenna A Mosier; Samantha C Schwager; David A Boyajian; Cynthia A Reinhart-King
Journal:  Clin Exp Metastasis       Date:  2021-06-02       Impact factor: 5.150

Review 4.  Metabolic rewiring in mutant Kras lung cancer.

Authors:  Emma M Kerr; Carla P Martins
Journal:  FEBS J       Date:  2017-06-22       Impact factor: 5.542

5.  (+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.

Authors:  Valéry L Payen; Paolo E Porporato; Pierre Danhier; Thibaut Vazeille; Marine C N M Blackman; Bronislav H May; Paul Niebes; Pierre Sonveaux
Journal:  Front Pharmacol       Date:  2017-12-04       Impact factor: 5.810

Review 6.  Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.

Authors:  Andrea Morandi; Maria Letizia Taddei; Paola Chiarugi; Elisa Giannoni
Journal:  Front Oncol       Date:  2017-03-14       Impact factor: 6.244

7.  Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer.

Authors:  Nicola Baldini; Angelo De Milito; Olivier Feron; Robert J Gillies; Carine Michiels; Angela M Otto; Silvia Pastoreková; Stine F Pedersen; Paolo E Porporato; Pierre Sonveaux; Claudiu T Supuran; Sofia Avnet
Journal:  Front Pharmacol       Date:  2017-07-04       Impact factor: 5.810

8.  MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity.

Authors:  Tania Capeloa; Joanna Krzystyniak; Donatienne d'Hose; Amanda Canas Rodriguez; Valery L Payen; Luca X Zampieri; Justine A Van de Velde; Zohra Benyahia; Erica Pranzini; Thibaut Vazeille; Maude Fransolet; Caroline Bouzin; Davide Brusa; Carine Michiels; Bernard Gallez; Michael P Murphy; Paolo E Porporato; Pierre Sonveaux
Journal:  Cancers (Basel)       Date:  2022-03-16       Impact factor: 6.639

9.  MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice.

Authors:  Tania Capeloa; Joanna Krzystyniak; Amanda Canas Rodriguez; Valéry L Payen; Luca X Zampieri; Erica Pranzini; Françoise Derouane; Thibaut Vazeille; Caroline Bouzin; François P Duhoux; Michael P Murphy; Paolo E Porporato; Pierre Sonveaux
Journal:  Cancers (Basel)       Date:  2022-03-15       Impact factor: 6.639

10.  The molecular mechanisms of celecoxib in tumor development.

Authors:  Bin Wen; Ying-Ting Wei; Lan-Lan Mu; Guo-Rong Wen; Kui Zhao
Journal:  Medicine (Baltimore)       Date:  2020-10-02       Impact factor: 1.817
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