Literature DB >> 27308445

To die, or not to die: E2F1 never decides by itself during serum starvation.

Daitoku Sakamuro1, Watson P Folk1, Alpana Kumari1.   

Abstract

The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.

Entities:  

Keywords:  BIN1; E2F1; PARP1; apoptosis; cell cycle; serum starvation

Year:  2015        PMID： 27308445      PMCID： PMC4904901          DOI： 10.4161/23723556.2014.981447

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.

Authors:  Jasmyne Carnevale; Oliva Palander; Laurie A Seifried; Frederick A Dick
Journal:  Mol Cell Biol       Date:  2011-12-19       Impact factor: 4.272

2.  The E2F transcription factor is a cellular target for the RB protein.

Authors:  S P Chellappan; S Hiebert; M Mudryj; J M Horowitz; J R Nevins
Journal:  Cell       Date:  1991-06-14       Impact factor: 41.582

Review 3.  E2F and cell proliferation: a world turned upside down.

Authors:  R A Weinberg
Journal:  Cell       Date:  1996-05-17       Impact factor: 41.582

4.  Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.

Authors:  A Kumari; T Iwasaki; S Pyndiah; E K Cassimere; C D Palani; D Sakamuro
Journal:  Cell Death Differ       Date:  2014-09-26       Impact factor: 15.828

5.  c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance.

Authors:  Slovénie Pyndiah; Satoshi Tanida; Kazi M Ahmed; Erica K Cassimere; Chungyoul Choe; Daitoku Sakamuro
Journal:  Sci Signal       Date:  2011-03-29       Impact factor: 8.192

6.  Binding and suppression of the Myc transcriptional activation domain by p107.

Authors:  W Gu; K Bhatia; I T Magrath; C V Dang; R Dalla-Favera
Journal:  Science       Date:  1994-04-08       Impact factor: 47.728

7.  BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.

Authors:  D Sakamuro; K J Elliott; R Wechsler-Reya; G C Prendergast
Journal:  Nat Genet       Date:  1996-09       Impact factor: 38.330

8.  The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage.

Authors:  E K Cassimere; S Pyndiah; D Sakamuro
Journal:  Cell Death Differ       Date:  2009-07-24       Impact factor: 15.828

9.  PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.

Authors:  Cynthia M Simbulan-Rosenthal; Dean S Rosenthal; RuiBai Luo; Raed Samara; Luis A Espinoza; Paul O Hassa; Michael O Hottiger; Mark E Smulson
Journal:  Oncogene       Date:  2003-11-20       Impact factor: 9.867

10.  Chk2 activates E2F-1 in response to DNA damage.

Authors:  Craig Stevens; Linda Smith; Nicholas B La Thangue
Journal:  Nat Cell Biol       Date:  2003-05       Impact factor: 28.824
  10 in total
  1 in total

1.  Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.

Authors:  Watson P Folk; Alpana Kumari; Tetsushi Iwasaki; Slovénie Pyndiah; Joanna C Johnson; Erica K Cassimere; Amy L Abdulovic-Cui; Daitoku Sakamuro
Journal:  J Biol Chem       Date:  2019-02-07       Impact factor: 5.157
  1 in total

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